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Biomedical subjects

M Hasue

Publications and source records attributed to M Hasue.

At least 37 records · Page 2Linked to original sources

[Compartmental syndrome of the lower limb--basic evaluation].

In order to clarify the structural background for compartmental syndrome in the lower limb, biomechanical study was carried out on cadavers and pathological investigation was done on amputated limbs in clinical cases. Experimental ligation of arteries was made on rats and histochemical analysis of the ischemic muscles was also performed. Furthermore, the pressure inside the leg compartments of normal controls was measured. Based on these observations, the following conclusions were drawn. Some structural specialties of compartments are responsible for the clinical fact that anterior compartment syndrome is most frequently seen in the lower limb. Circular fibers existing at the wall of the anterior compartment is probably related to frequent occurrence of a high pressure in the compartment. In the muscle with ischemic changes, regenerating muscle fibers are found just under the fascia. This fact suggests that the muscle fibers have possibilities of regaining their function. Ischemic change of nerves is more severe in the peroneal than in the tibial nerves. This fact may be due to the anatomical specialties of compartments rather than circulatory characteristics of nerves themselves.

Adult↗

[Concentration of cefotiam in the human bone marrow fluid and bone tissue (author's transl)].

The preoperative administration of cefotiam (CTM) 1 g by intravenous drip infusion for 30 minutes was performed. And the concentration of CTM in peripheral blood, bone marrow fluid and bone tissue was investigated. CTM was smoothly transmigrated from blood to bone tissue, and kept on the concentration in bone tissue over MIC values for several hours. These preliminary results encourage us to think that CTM may be as useful in prophylaxis against postoperative infections.

Adult↗

[Concentration of dibekacin sulfate in bone (author's transl)].

The concentrations in serum, cancellous and cortical bones of dibekacin sulfate were measured in 16 cases. Dibekacin sulfate rapidly penetrates into bone. The peak concentration in serum and cancellous bone is reached within 1 hour after intramuscular injection and the concentration in cancellous bone parallels that in serum. The concentration in cortical bone increases with time. Cancellous bone has higher concentration than cortical bone. Dibekacin sulfate is suitable for prevention of infection in orthopaedic surgery, because it maintains a bactericidal level in bone for enough time.

Adult↗

Metaphysial dysostosis (Jansen type). Report of a case with long follow-up.

A case of the Jansen type of metaphysial dysostosis, followed for fifteen years from childhood to the age of nineteen, is reported. Radiographs taken at five years revealed the characteristic metaphysial changes in all the tubular bones, especially those of the hands and feet. The acetabular and glenoid areas, the costochondral junctions and the sternal ends of the clavicles were also involved. Radiographs taken at nineteen years, however, showed only marked deformities, which shows that the involvement of the metaphyses can regress by the end of growth. Biopsy of the lower end of radius at the age of twelve revealed changes in the growth plate or physis, especially in the zone of resting cartilage. This finding suggests that cellular function in this zone is disturbed by some unknown mechanism. Hence, the term physial dysostosis may be more accurate than metaphysial dysostosis.

Adult↗

Epidemiologic and clinical studies of long-term prognosis of low-back pain and sciatica.

In order to justify the selection of therapeutic measures for low-back pain and sciatica, epidemiologic and clinical studies were performed of the natural histories or the long-term prognosis of those symptoms. The main conclusions drawn in relation to decision making are as follows: low-back pain is more frequent than sciatica or intermittent claudication, but the latter is more disabling; acute attacks are generally more disabling than chronic pain, and the frequency may be more closely related to poor prognosis than the duration; radiologic findings are of little value in differentiating the incidence and degree of the symptoms during life; myelographic or peridurographic abnormalities do not always suggest poor prognosis.

Acute Disease↗