PubMed Health⌕ Search

Biomedical subjects

M Hatta

Publications and source records attributed to M Hatta.

63 records · Page 4Linked to original sources
PubMed1985

[Influence of immunopotentiators on the activation of 5-FU derivatives].

As it has been shown that various kinds of immunopotentiators inhibit the hepatic microsomal drug-metabolizing enzymes and reduce the activation of masked compounds such as tegafur, we investigated the influence of immunopotentiators (OK-432 and PSK) on the activation of carmofur (HCFU), which is known to be transformed spontaneously in to the tumor-active substance, 5-fluorouracil (5-FU), in vivo, and compared the results to those obtained for tegafur. After oral administration of tegafur, the area under the plasma concentration curves of 5-FU in rats pretreated with OK-432 and PSK were 72% and 79% of those in untreated rats, while in the case of HCFU almost similar plasma concentration curves for 5-FU were obtained in both treated and untreated rats. These results show that the activation of HCFU to 5-FU is not influenced by treatment with these immunopotentiators. Furthermore, our clinical investigation showed that the survival curves of cancer patients given combination therapy of tegafur with OK-432 tended to be lower than those given a single therapy of tegafur, supporting the above mentioned basic results.

Adjuvants, Immunologic↗
PubMed1984

[Functional preservation in cancer surgery of the large intestine].

Distal Surgical margin, required in the sphincter preserving operation for rectal cancer was studied histologically on the 78 resected specimens. The extramural cancer spread, examined by clearing method, was found in 20.5%, and was more frequent and expansive compared to intramural spread of cancer. No distal spread was found in cancer limited to the rectal wall. Length of the spread by 3 cm in lower rectal cancer and 4 cm in the upper rectal cancer. Postoperative anal function showed a good or fair in patients with internal sphincteric function preserved. Postoperative dysuria and male sexual disturbance showed a close relation to the pelvic nodes dissection. Ro-dissection was followed by 20% of dysuria, while RI and R 2 46.7%, R 3 1.8%.

Anal Canal↗
PubMedDate not supplied

Distribution and persistence of Mycobacterium leprae nasal carriage among a population in which leprosy is endemic in Indonesia.

In order to understand better the relationship among Mycobacterium leprae, its transmission and the human host or the chain of infection which may lead to the development of leprosy, we performed a population survey in which nasal carriage of M. leprae was determined by a specific polymerase chain reaction (PCR), 2 years after an earlier survey in the same population. 1923 persons were registered, 1171 were clinically examined for signs of leprosy, and 418 were tested by PCR. The detection rate of leprosy in the study area had not changed significantly during the 2 years' observation period since the introduction of multi-drug therapy, i.e. 6/1000 compared to 7.7/1000 2 years before. Of 6 newly detected cases, 5 were diagnosed as having paucibacillary leprosy. The presence of M. leprae could be demonstrated by PCR in 2.9% (12/418) of the persons. PCR positivity was not persistent over the 2 years. All the PCR positive persons identified in the first survey were negative in the second, indicating that M. leprae nasal carriage is transient. As in the previous survey, we found evidence for widespread M. leprae nasal carriage as determined by PCR among the general population in an area in which leprosy is endemic. In addition, our data indicated that PCR positivity can occur in certain clusters in the community. This clustering seems to be time-dependent, not necessarily related to the presence of patients.

Adolescent↗