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Biomedical subjects

M Haupt

Publications and source records attributed to M Haupt.

At least 73 records · Page 4Linked to original sources
PubMed1985

Hemodynamic instability associated with balloon catheter traction after transurethral surgery.

Severe vasovagal reactions were experienced by three patients in whom balloon catheter traction was used to assist hemostasis after transurethral procedures. Release of catheter traction, along with conventional resuscitative measures, led to resolution of cardiovascular instability. Prompt recognition of the potential relationship between vasovagal reactions and parasympathetic stimulation that may accompany bladder base compression by catheter balloon is emphasized.

Acute Disease↗
PubMed1981

Ultrasonic induction of sister chromatid exchanges in human lymphocytes.

We analyzed sister chromatid exchange (SCE) frequencies as an indicator of DNA damage induced in human lymphocytes by 'real-time' ultrasound. A range of exposure times and intensities was tested in a series of blind, randomized, in vitro experiments under spatial and sonographic conditions simulating exposure of a gravid abdomen and uterus. Our studies showed small but consistent effects of ultrasound on SCE frequencies, for each experiment. Differences between matched control and exposed means were significantly different from zero. chi 2 tests for homogeneity indicated no significant differences among either the means or the total distributions of the controls, nor among each of the separate dose levels. Consequently, experiments were pooled, and chi 2 analysis indicated significant differences both among distributions and among means of SCE frequencies for controls versus exposed cells (P less than 0.001). The pooled control mean was also significantly different from each of the pooled dose means. Correcting for multiple comparisons gave identical results for the paired comparisons of means except for the 20-min level which was borderline (0.025 less than P less than 0.01). We conclude that the well-established value of clinical ultrasonography warrants its continued use; however, minimizing the numbers and lengths of exposure per patient would seem prudent, pending further information on clinical implications of our results.

Adult↗
PubMed1979

[Possibilities and limits for palsied children in the general polytechnical school (author's transl)].

Some children with cerebral palsy attend the ten-form general polytechnical school. To this end, several prerequisites have to be fulfilled and other essential arrangements to be developed in cooperation with specially trained teachers. The learning conditions have to be fitted to the improving abilities of children during the educational process. Factors of influence and cooperation modes are discussed.

Adolescent↗
PubMed1978

Comparative studies on the metabolism of oestradiol in the brain, the pituitary and the liver of the rat.

Radioactive oestradiol was incubated with homogenates of hypothalamus, pituitary and liver and slices of cortex, hippocampus, hypothalamus, pituitary and liver of ovariectomized rats. 2- and 4-substituted oestrogens were the main metabolites in the brain and were found in the same proportions. In the liver only the 2-substituted oestrogens were the main metabolites, while the 4-substituted ones were of minor quantitative importance. On the basis of wet weight the 2-hydroxylating capacity of the liver was approximately 50 fold greater than that of the brain and the 4-hydroxylating capacity about the same as that of the brain. Only slight differences in the 2- and 4-hydroxylating capacity of various brain areas were observed, although apparently the hypothalamus and the pituitary were more active in the formation of catecholestrogens than the cortex and the hippocampus.

Animals↗
PubMed1978

[Hydrocephalus].

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Child↗
PubMed1976

The haemolytic effect of phallolysin.

Phallolysin from the toadstool, Amanita phalloides, is a basic protein that causes direct haemolysis of red cells. The dose-response curve is steep; the pH optimum is in the weakly acid range. The rate of haemolysis increases with the concentration of the lysin, the optimal temperature is 20 degrees C. The percentage haemolysis-time curves are S-shaped. Haemolysis is of the non-osmotic type. Ca2+ is not required but inhibits haemolysis in a concentration-dependent fashion, as do Mg2+ and Zn2+. The red cell sensitivity of various animal species decreases in the following sequence:mouse greater than rabbit = guniea pig greater than rat greater than man greater than dog approximately or equal to pig greater than sheep = cattle. Red cells of cattle and sheep are largely resistant. Phallolysin is virtually not consumed on haemalysis: the amount of haemoglobin released increases with the number of red cells applied; on repeated addition of fresh red cells the haemolysate retains its full activity. Phallolysin is not inhibited by serum, albumin, cholesterol, lecithin, cephalin or sphingomyelin; inhibition by red cell ghosts of phallolysin haemolysis is considerably less than that of digitonin haemolysis. At sublytic concentrations phallolysin, unlike benzalkonium chloride, liberates practically no membrane lipids from human red cells. Surface activity of phallolysin does not exceed that of bovine serum albumin.-A saponin-like interaction with cholesterol as the basic mechanism of haemolysis can be disregarded. There is also no evidence suggesting a detergent-like effect.

Amanitins↗