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Biomedical subjects

M Hautecouverture

Publications and source records attributed to M Hautecouverture.

10 recordsLinked to original sources
PubMed1992

[Lipid balance in an arteritic patient and therapeutic implications].

The pathogenesis of atherosclerosis remains hypothetical, the current vogue of a lipidic origin being now only a working hypothesis. The management of an arteritic patient (for a treating clinician) is that of a case of global atherosclerosis. Screening for lipids: 1) is here of only moderate interest in the close scrutiny of currently recognized risk factors, and 2) should include initially a simple study of total plasma cholesterol (TC) and triglycerides (TG) on two occasions at one month's interval in a reliable laboratory. Therapeutic implications are a function of a global analysis of the patient and not just the values for even sophisticated assays of circulating lipids.

Arteritis↗
PubMed1979

Treatment of Cushing's disease by O,p'DDD. Survey of 62 cases.

In a study of nonsurgical therapy of Cushing's disease, 62 patients received O,p'-dichlorodiphenyldichloroethane (O,p'DDD), 16 of whom also received cobalt irradiation of the pituitary. After an initial treatment period averaging eight months, a remission of the disease was obtained in 38 of the 46 patients given O,p'DDD alone and in all patients who received drug combined with radiation. Although 60 per cent of these patients subsequently relapsed, additional courses of drug or radiation therapy were usually effective, and 63 per cent of the entire group of patients have so far been kept under control without adrenalectomy. (Forty patients have been followed for at least two years after the initial course of treatment.). O,p'DDD produced little gastrointestinal discomfort; an increased serum cholesterol was the main side effect. This drug allows long-term medical management of Cushings disease in most cases. Whether the combination of O'p'DDD with pituitary radiation is the best therapy has not been established.

17-Hydroxycorticosteroids↗
PubMed1978

[Myxedema coma].

Explore the source record for details and available documents.

Coma↗
PubMed1978

Double blind clinical trial of mazindol on weight loss blood glucose, plasma insulin and serum lipids in overweight diabetic patients.

Mazindol, a drug with tricyclic structure unrelated to amphetamine and other anorectic drugs, has been used as an anorectic agent in a double blind clinical trial at a dose of 2 mg/day for 12 week (mazindol v. s. placebo), associated with a 1000 calorie diet on 46 obese diabetic patients. Thirty seven patients completed the trial with no significant difference between the two groups in the drop-out population; mazindol was well tolerated. In the mazindol-treated group the mean weight loss was 13.5 kg (22.3%) which was significantly greater (p less than 0.001) than in the placebo treated group where the mean weight loss was 4.2 kg (9.8%). Comparing the two groups after the 12 week trial, decrease in fasting blood glucose, serum insulin and triglycerides was not significant. In the mazindol-treated group a significant decrease of serum cholesterol, triglycerides and of the mean area under the curve of insulinemia during the OGTT has been observed. In the placebo treated group only serum triglycerides decreased significantly. The variations of plasma insulin and serum cholesterol were found to be correlated to the magnitude of weight loss. In conclusion mazindol is an effective drug for weight loss on the whole well tolerated but without specific properties on metabolism.

Blood Glucose↗
PubMed1976

[Sex differences in the blood glucose fall induced by short fasts (author's transl)].

Overnight fasting venous plasma glucose concentration was lower in premenopausal women than in men. This difference increased during a low caloric and low carbohydrate diet and above all after a 48 h fasting period. Venous blood glucose variation during this period of fasting was the same in post-menopausal women as in men. These facts and the previous observation by our group of a fall in fasting and post absorptive venous blood glucose after intramuscular injection of oestradiol benzoate (10) indicate that sex variations in the blood glucose fall following a period of fasting are at least partly linked to the oestrogenic status of the premenopausal woman.

Blood Glucose↗
PubMed1975

Study of glucagon secretion using in vitro perifusion of rat pancreas pieces.

The in vitro perifusion technique of rat pancreatic tissue has been studied in respect of sensitivity and reproducibility regarding alpha-2-cell function. Convenient and quickly performed, it allows the kinetic analysis of humoral factors of glucagon release when the blood vessels are too small to be cannulated, for instance in case of fetal pancreas and of tumor tissue. A2 cells in the perifused pancreatic tissue release glucagon in response to arginine, norepinephrine and the decrease of glucose concentration in the medium. The sensitivity of this preparation is lower than that of the perfused pancreas: this may be related to unphysiological conditions of fluid circulation, of the degradation of the stimuli and degradation of the hormone released. Satisfactory conditions of perifusion flow rate and amount of panceatic tissue have been defined and several protective agents have been tested.

Acetylcholine↗
PubMedDate not supplied

[Glucocorticoids and gluco-lipidic metabolism].

Glucocorticoids increase the stocks of carbohydrate and the supra-hepatic flow of glucose. Their excess produces a centripetal redistribtution of adipose stocks and potentialises adipocyte lipolysis. Although their role of glucose and lipid metabolism is evident, the mechanisms and sites of action of glucocorticoids are multiple and not entirely clear. The actions of glucocorticoids become clear in cases of insulin deficiency, especially when the deficiency is marked, which is of great interest in current medical practice.

Adipose Tissue↗