Biomedical subjects
Publications and source records attributed to M Hayaishi.
An in vitro study on the effects of hyaluronan (HA) on interleukin-1 alpha-induced prostaglandin E2 (PGE2) production in human osteoarthritic synovial cells indicated that PGE2 induction was suppressed by HA in a dose- and molecular weight-dependent manner.
The effects of hyaluronan (HA) on the release of arachidonic acid (AA) from phospholipids induced by bradykinin in synovial fibroblasts of osteoarthritic patients were examined. HA inhibited [14C]AA release from prelabeled synovial cells stimulated with and without bradykinin 1 hr after incubation with HA and thereafter. The inhibitory effects of HA on [14C]AA release were dependent on the concentration and molecular weight of HA. However, inhibition of [14C]AA release by HA was not merely due to the viscosity of HA. The [14C]AA release induced by calcium-ionophore A23187 was also inhibited by HA with a high molecular weight. In addition, HA did not affect [14C]AA uptake by the cells. Our results suggest that HA with a high molecular weight elicits anti-inflammatory effects, at least in part, by inhibiting AA release in inflamed joints.
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To determine whether high-resolution CT (HRCT) is useful for diagnosing patients with multi-focal pulmonary consolidation observed on chest radiography, we reviewed the HRCT scans of 80 patients with various kinds of diseases. The patients were divided into three groups: those with infectious diseases (group A, n = 28), those with non-infectious diseases in which the use of corticosteroids was the treatment of choice (group B, n = 33), and others (group C, n = 19). Centrilobular branching structure, small nodules within the consolidation, and segmental distribution were specific or more prevalent in group A. Ground-glass attenuation, air-bronchiologram, and non-segmental distribution were more prevalent in group B. Consolidation composed of central homogeneous area and its surrounding small nodules was specific for group C, especially for sarcoidosis. In conclusion, HRCT provides more useful information in diagnosing patients with multifocal consolidation than does chest radiography or conventional CT.