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Biomedical subjects

M Hegedüs

Publications and source records attributed to M Hegedüs.

At least 37 records · Page 2Linked to original sources
PubMed1989

The value of crude protein content and in vitro pepsin digestibility of abattoir by-product meals in the prediction of their available protein content.

Amino acid composition of meat-and-bone meals, poultry by-product meals, blood meals, bone meals and feather meals showed characteristic differences. Meat-and-bone meals and blood meals had surplus in lysine, whereas poultry by-product meals and feather meals were relatively rich in cystine. Blood meals had high levels of branched-chain amino acids as compared to isoleucine. In vitro pepsin digestibility of meat-and-bone meals (79.9 +/- 17.7%; n = 24) and blood meals (95.8 +/- 4.2%; n = 11) was found to be higher than that of poultry by-product meals (65.3 +/- 7.7%; n = 14) or feather meals (44.7 +/- 9.2%; n = 16). Pepsin digestibility of poultry by-product meals showed a significant negative correlation with crude protein content (r = -0.73; P less than 0.05; n = 14). However, in vitro pepsin digestibility of poultry by-product meals as well as meat-and-bone meals, blood meals and feather meals, showed insignificant correlations with NPU indices as well as with available crude protein contents of the meals. The NPU values of meat-and-bone meals for rats (29.9 +/- 11.7; n = 100) were lower than those of poultry by-product meals (52.1 +/- 7.1; n = 14). The NPU values of blood meals (6.4 +/- 5.6; n = 11) and feather meals (23.5 +/- 10.0; n = 16), determined as sole sources of protein, were low and they did not elicit weight gain in rats. The available crude protein content of poultry by-product meals (34.3 g/100 g +/- 3.6; n = 14) was higher than that of meat-and-bone meals (17.0 g/100 g +/- 7.3; n = 100).(ABSTRACT TRUNCATED AT 250 WORDS)

Abattoirs↗
PubMed1989

Possible involvement of the dopaminergic system in the mode of action of the potential antidepressant trazium esilate.

Trazium esilate (EGYT-3615) is structurally an as-triazino isoquinolinium salt which showed considerable activity in pharmacological tests characteristic for antidepressants (antagonism of tetrabenazine, potentiation of yohimbine, behavioral despair). The compound exhibited minimal sedative effect. Some findings suggest that it influences the central dopaminergic system. The drug potentiated actions of amphetamine such as stereotypy and hypermotility. It differentially blocked the hypothermic and the stereotypy inducing action of apomorphine. Trazium esilate also inhibited the cataleptic state provoked by bulbocapnine in mice. In higher dose it decreased the plasma prolactin level in rats. The compound potentiated the effect of norepinephrine on isolated vas deferens of the rat. Trazium esilate is a weak displacer on a1-, a2- and D2-receptors, however, it induced a2-receptor desenzitization after repeated treatment. It had no influence on rat brain cortical noradrenaline and striatal dopamine release evoked by high K+ concentration, but it increased the spontaneous dopamine outflow in rat striatum. The compound also elevated the striatal dopamine and DOPAC levels both after acute and chronic treatment.

Animals↗
PubMed1989

Chemical composition and vitamin B content of abattoir by-product meals.

Chemical composition of meat-and-bone meals (n = 22), poultry by-product meals (n = 12), blood meals (n = 6), bone meals (n = 4) and feather meals (n = 8) indicated a slight degree of overdrying. Crude fat and ash contents were within the acceptable limits. Mineral elements of bones were determinative in the element pattern of meat-and-bone meals as indicated by the significant correlations between Ca, P and Mg. Crude protein was in negative regression and correlation with crude ash content (r = -0.81; P less than 0.001). This was more pronounced when the data were expressed in fatless dry matter (r = -0.94; P less than 0.001). Crude protein also showed significant negative correlations with Ca, P and Mg contents, offering the possibility to predict their levels from nitrogen content. Meat-and-bone meals and poultry by-product meals were relatively rich sources of riboflavin, niacin, pantothenic acid and biotin, whereas their pyridoxine and thiamine contents were low. Blood meals, bone meals and feather meals were found to be negligible vitamin B sources. Vitamin B and crude protein content of abattoir by-product meals showed uncertain correlations.

Abattoirs↗
PubMed1989

Traditional and new concepts in protein evaluation of feeds: a review.

The purpose of protein evaluation of a diet is to determine its value for meeting amino acid requirements of animals. The early recognition that proteins can be utilized by different efficiency rates has promoted extended research to reveal quality differences and their reasons. A brief historical overview is given in this review about the development of concepts and theories in protein evaluation. Recent developments have focused attention on determination of available quantities of essential amino acids. In vitro chemical assays and dye-binding procedures are relatively fast and provide data without access to animals, however they do not always correlate well with biological estimates. Enzymic digestion methods and microbiological assays for prediction of availability of essential amino acids have the potential for serial determination in quality control, however they are constrained by a lack of information about the availability of peptides liberated and utilized during in vivo digestion of proteins. Animal growth assays and balance experiments can provide valuable estimates of available quantities of essential amino acids. However, the interpretation of data is complicated by the many factors affecting in vivo protein utilization, by the endogenous amino acid excretion and the effects of microflora of the alimentary tract. The search for reliable assays remains a worthwhile objective also in the future.

Amino Acids↗
PubMed1985

Diagnostic accuracy of lymphangiography in the demonstration of histologically verified retroperitoneal lymph node metastases of testicular tumours.

Bipedal lymphangiography was performed in 101 cases of testicular tumour for the detection of retroperitoneal lymph node deposits. The lymphangiograms of 51 patients have been checked against the results of microscopic study of lymphadenectomy specimens. The radiogram was false-positive in 3, false-negative in 7 cases. The lymphangiographic diagnosis was accurate in 81 per cent of the cases. The other diagnostic possibilities--computerized tomography, ultrasonography, isotope lymphangiography--are also discussed. The main advantage of bipedal lymphangiography is to provide information on the structures of the lymph nodes and on the lymphatic channels as well. Combination of several diagnostic methods provides for a high accuracy of staging.

False Negative Reactions↗
PubMed1985

Primary ureteral tumours.

The authors report on the clinical picture, diagnostics and therapy of ureteral tumours in 4 patients. The most important symptoms are haematuria and pain. Of the diagnostic possibilities retrograde ureterography is the most significant. Their own surgical solution was ureteronephrectomy with excision of the orifice. Also the conservative therapeutic measures were surveyed. The post-operative control for detecting early recurrences is considered important.

Carcinoma, Transitional Cell↗
PubMed1982

Escherichia coli strains isolated from surface waters. Distribution by resistance to antibiotics and R-plasmid transfer.

Samples were taken from surface waters in Csongrád county in the months March through December, 1980. Escherichia coli isolates selected at random were tested for resistance to 5 antibiotics and for R-plasmid carriership. Of the strains isolated from Tisza river at each of 8 sampling sites, 50-60% were sensitive to all the 5 antibiotics. The percentage of sensitivity was much lower if only the strains isolated during the summer months, when the water level was high, or those isolated from affluents and backwaters were taken into account. The frequency of resistance was the highest for tetracycline, followed in order by ampicillin, streptomycin, kanamycin and chloramphenicol. R-plasmid was carried by 43% of the resistant isolates tested, mainly by multiresistant ones.

Ampicillin↗