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M Heppeler

Publications and source records attributed to M Heppeler.

3 recordsLinked to original sources

[Polymorphous light dermatosis. Clinical data and test results].

In a retrospective study, the clinical data of 424 patients, 340 (= 80.2%) female and 84 (= 19.8%) male, with polymorphous light eruption (PLE) were evaluated; 89.1% of the patients had skin type II or III (according to Fitzpatrick). 368 Photoprovocation testing was performed on 332 of these cases. The duration of PLE was (mean +/- SD) 7 +/- 6.9 years, and the age at onset of the disease was 28 +/- 14 years. In 40.1% of the patients PLE developed without seasonal accentuation. Predilection sites for skin lesions were the extensor aspects of the upper arm or forearm (69.0%/66.7%) and the chest (59.5%); the face and the back of the hand were less frequently (41.0%/40.8%) affected. In most cases (53.6%/18.3%), the skin lesions were papular or erythemato-urticarial in type. The minimal erythema dose for UV-B was found to be normal in all 311 cases in which it was assessed. Photoprovocation testing yielded skin lesions of PLE in 38.4% of the female, and in 58.5% of the male patients. The frequency of positive reactions to photoprovocation testing was directly related to the duration of the disease, the persistence of naturally occurring lesions, and the time interval from accidental exposure to the development of lesions.

Adolescent↗

Preventive effect of an E. coli-filtrate (Colibiogen) in polymorphous light eruption.

During the administration of Colibiogen, a commercially available E. coli-filtrate, there was a significant (P less than 0.01) increase of the test dose of UVA necessary to elicit skin lesions in nine patients with polymorphous light eruptions. Control tests performed in the same manner without the drug indicate that this was due to treatment. Colibiogen appears to be of value in the treatment of polymorphous light eruption (PLE).

Adult↗

Polymorphous light eruption: eliciting and inhibiting wavelengths.

In 38 patients with polymorphous light eruption (PLE) photoprovocation tests were performed by applying 100 J/cm2 of UV-A to the extensor side of the upper arm on three consecutive days. Test sites were divided into four areas by covering the patients' skin with Schott glass filters WG 320, WG 335, WG 360, and GG 385 (or GG 395). In 17 patients typical skin lesions could be provoked in at least one test field. 10 patients reacted either at all test sites or at shorter wavelengths (simultaneously higher doses) only. In the remaining 7 patients test reactions did not occur underneath filters with lower cut-off points, whereas skin lesions were induced by radiation deprived of the shorter wavelengths passing through these filters. This observation suggests an inhibitory effect of shorter wavelengths in these cases.

Humans↗