Biomedical subjects

M Hernandez-Gonzalez

Publications and source records attributed to M Hernandez-Gonzalez.

3 recordsLinked to original sources

PubMed2000

Alcohol before puberty produces an advance in the onset of sexual behavior in male rats.

The effect of alcohol consumption before puberty on the development of genital-grooming (GG) and on the onset of sexual behavior was assessed. Wistar male rats were continuously exposed in a one-bottle access situation to either 6% ethanol (alcohol group, AG), an isocaloric sweetened solution (vehicle group, VG) or were maintained in standard laboratory conditions (control group, CG). Each solution was the only available liquid in each group from weaning (22 days) to 40 days of age. GG behavior was recorded from 25 to 47 days of age and sexual behavior was recorded from 42 to 74 days of age. The age at the maximum peak of both frequency and duration of GG showed an advance in the AG (33-35 days of age) compared with the CG (45 days) and the VG (47 days). An advance in the onset of sexual behavior was observed in the AG: at 46 days of age, seven of the nine males of this group showed ejaculatory behavior. In contrast, in the CG and VG, ejaculation occurred in at least 50% of subjects after 58 days of age. Regardless of the advance in the onset of sexual behavior, the characteristics of the different parameters of the copulatory sequence were not impaired by alcohol. The apparent advance in the onset of puberty is discussed in terms of the opioid hypothalamic activity as a mechanism that affects the LH secretion.

Aging↗

PubMed1997

Subcortical multiple unit activity changes during rat male sexual behavior.

Multiple unit activity (MUA) was recorded from the ventral tegmental area (VTA) and mesencephalic locomotor region (MLR) during copulatory behavior of freely moving male rats. Simultaneous accelerometric recordings of the copulatory pelvic thrusting performed by the male rat were taken to precisely correlate in time the changes in MUA with well defined elements of copulation. The baseline MUA firing rates recorded in the quiet-alert condition in the VTA and in the MLR were significantly increased during pursuit of the female by the male; significantly higher MUA firing rates were found in the VTA at the 500 ms periods before and during the execution of pelvic thrusting in mount, intromission, and ejaculation responses as compared to the baseline, and returned to this value when these responses ended. The maximum MUA firing rate in the MLR was obtained during the execution of pelvic thrusting in each copulatory response, and it remained significantly elevated, as compared to the baseline, after thrusting and at the postintromission and postejaculatory genital grooming, then decreasing to basal values at the initial part of the postejaculatory interval. The fact that the highest changes in MUA were related to pelvic thrusting suggests a major participation of both structures in the execution of motor copulatory responses.

Animals↗

PubMed1997

Computer programs to analyze brain electrical activity during copulatory pelvic thrusting in male rats.

Two microcomputer programs have been developed to simultaneously record and analyze the brain electrical activity: multiple unit activity (MUA) and electroencephalogram (EEG), and the accelerometric signals generated in relation to the pelvic thrusting that performs the male rat during the copulatory responses of mount, intromission, and ejaculation. CAPTUMUL is a program allowing the on line capture of the different signals and the further off line delimitation of the brain signals occurring in exact temporal relation with the accelerometric record of motor responses. The ANAMUA program allows the off line analysis of the neuronal firing rate in MUA records at different discrimination levels according to the amplitude of the neuronal spikes, and compare these data in various behavioral situations. The use of these programs provides a way of correlating in time the changes of brain electrical activity occurring in animals in free-movement with the brief motor events of copulation as well as with other behaviors (i.e., genital grooming, sniffing, running, walking). Advantages of this software include the recording of sequential events, a better and rapid handling of data and a reliable method to analyze the MUA with different discrimination levels according to the amplitude of the neuronal spikes.

Animals↗