Management of a giant ovarian cyst.
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Adult↗
Biomedical subjects
M Hershman
Publications and source records attributed to M Hershman.
A prospective comparative study of cefotetan with piperacillin for prophylaxis against infection in elective colorectal surgery.
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Cefotetan↗
Desaturation-producing factor present in the tissue, blood, and urine of cancer patients.
Patients with liver neoplasms have a significantly lower stearic to oleic ratio (SI) in tumour (x = 0.36) vs non-tumour liver tissues (x = 0.75; P less than 0.001). The SI of circulating erythrocytes is lower in cancer patients (n = 100; X = 0.69) than noncancer patients (n = 50; x = 1.45) and normal subjects (n = 50; x = 1.5) (p less than 0.001). It was also found that urine protein extracts from cancer patients reduce the SI of cultured cell membrane (n = 10; x = 0.74) as compared to urine from noncancer patients (n = 10; x = 1.02; p less than 0.001). This study suggests that patients with cancer release a desaturation-producing factor from the malignant cells into the systemic circulation and subsequently into the urine. The observed increased unsaturation (oleic acid) in the circulating erythrocytes can be useful in the diagnosis and postoperative monitoring of cancer patients.
Adult↗
Rectourethral fistula: a rare cause of infertility.
Rectourethral fistulas are rare, and infertility due to rectal ejaculation is extremely rare. We report a case of congenital rectourethral fistula presenting as infertility due to rectal ejaculation.
Adult↗
A low pH enzyme linked immunoassay using two monoclonal antibodies for the serological detection and monitoring of breast cancer.
A new, simple and sensitive low pH ELISA method has been developed to measure serum levels of tumour associated antigens detectable by monoclonal antibodies HMFG1 and HMFG2. We examined sera from healthy controls, patients with neoplastic and non-neoplastic conditions of breast, liver and gastrointestinal tract. The majority of patients with metastatic breast cancer had elevated serum antigens (69% HMFG1, 72% HMFG2) compared to healthy controls (6.3% HMFG1, 3.0% HMFG2) or patients with benign breast disease (17% HMFG1, 4% HMFG2). There was no discrimination using these assays between patients with neoplastic and non-neoplastic conditions of liver and gastrointestinal tract. This new method promises to be of value in the assessment and management of patients with breast cancer.
Antibodies, Monoclonal↗
Increase of oleic acid in erythrocytes associated with malignancies.
Total lipid extracts of erythrocyte cell membranes from 60 patients with documented malignancies, 41 patients with various acute and chronic diseases, and 40 healthy subjects were analysed. The results were expressed as ratios of stearic to oleic acid, reflecting the degree of desaturation of stearic acid. The mean ratios for the healthy subjects and controls without cancer were 1.5 (SD 0.27) and 1.45 (0.28), respectively, whereas the ratios for patients with malignancies were consistently lower than the cut off point of 1.0, with a mean of 0.69 (0.15) (p less than 0.001). The desaturation ratio was also significantly lower (p less than 0.001) in the group with recurrent tumours (mean 0.75 (0.04)) compared with those with no evidence of recurrent tumours (mean 1.55 (0.27)). It is suggested that the increased unsaturation (oleic acid) in the circulating erythrocytes may be useful in the diagnosis and postoperative monitoring of patients with cancer.
Erythrocyte Membrane↗
Reduction in the stearic to oleic acid ratio in human malignant liver neoplasms.
Total lipid extracts of liver tissue from 14 patients with primary and secondary liver tumours were analysed for relative values of saturation of 18 carbon chain length fatty acids (C18FA). The saturation indices (ratio C18S:C18u) of the tumour areas were significantly and consistently lower than the corresponding values in the non-tumour areas (P less than 0.001). It is proposed that the relative increase in unsaturated C18FA (oleic acid) could prove to be a chemical marker reflecting deficient cellular control of the desaturation of stearic acid.
Adult↗
Anorexia nervosa and Crohn's disease.
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Adult↗
Serum levels of c-myc and c-ras oncogene products in normal subjects and in patients with neoplastic and non neoplastic conditions.
A new, simple and sensitive low pH ELISA system has been developed and used to measure serum levels of c-myc and c-ras oncogene products in healthy blood donors and patients with neoplastic and non neoplastic conditions. Blood donors had significantly lower serum levels of oncogene products than patients with cancer or other pathologies (p-value less than 0.01). There was, however, no difference between patients with neoplastic and non-neoplastic conditions. Although c-myc and c-ras oncogene products in the serum appear to discriminate between healthy state and pathological conditions they do not discriminate between neoplastic and non-neoplastic conditions.
Biomarkers, Tumor↗
Transanal endoscopic microsurgery.
Transanal endoscopic microsurgery is a minimally invasive technique for local excision of tumours in the rectum and lower sigmoid colon. It allows precise transanal dissection and suturing, and enables sphincter-preserving local resection to be performed without an abdominal or perineal incision.
Electrocoagulation↗