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M Hertzog

Publications and source records attributed to M Hertzog.

5 recordsLinked to original sources
PubMed2005

Actin polymerization machinery: the finish line of signaling networks, the starting point of cellular movement.

Dynamic assembly of actin filaments generates the forces supporting cell motility. Several recent biochemical and genetic studies have revealed a plethora of different actin binding proteins whose coordinated activity regulates the turnover of actin filaments, thus controlling a variety of actin-based processes, including cell migration. Additionally, emerging evidence is highlighting a scenario whereby the same basic set of actin regulatory proteins is also the convergent node of different signaling pathways emanating from extracellular stimuli, like those from receptor tyrosine kinases. Here, we will focus on the molecular mechanisms of how the machinery of actin polymerization functions and is regulated, in a signaling-dependent mode, to generate site-directed actin assembly leading to cell motility.

Actin Cytoskeleton↗
PubMed1996

Educating every teacher, every year: the public schools and parents of children with ADHD.

This article reports findings from interviews with 20 parents about their experiences in obtaining services for their ADHD children in school systems. Grounded theory methods were used to analyze data at both individual and organizational levels. Parents saw school personnel as varying widely in their knowledge about ADHD and their acceptance of its associated problems. At the individual level, parents felt that they had to educate a succession of different school personnel each year. At the organizational level, they had to work actively to obtain continuity of services for their children from year to year and school to school, but for most parents, this outcome was desired more often than realized. On the whole, parents perceived schools as having failed to respond adequately to their children's educational needs.

Adolescent↗
PubMed1990

[Coronary reperfusion by anistreplase (Eminase) used intravenously during the acute phase of myocardial infarction].

Coronary recanalisation rate is one of the parameters utilized to evaluate the effectiveness of a thrombolytic agent. This parameter can only be measured when the occlusion and reopening of the coronary artery involved are demonstrated by angiography. Moreover, this type of study enables the kinetics of drug activity to be accurately determined. When injected intravenously in doses of 30 units less than four hours after the onset of chest pain and when studied by this method, Eminase produces recanalisation in more than 60 per 100 of the cases. The time elapsed between injection and action is 45 minutes on average. The risk of early reocclusion is low (about 5%). The recanalisation rate obtained with Eminase is similar to that obtained with intracoronary streptokinase.

Anistreplase↗