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Biomedical subjects

M Hetreed

Publications and source records attributed to M Hetreed.

6 recordsLinked to original sources
PubMed1996

Evaluation of the contribution to postoperative analgesia by local cooling of the wound.

Thirty healthy patients undergoing lumbar spine surgery were randomly assigned to one of two groups for postoperative pain relief. Group 1 received morphine via patient controlled analgesia and local cooling of the wound by an externally applied cooling pad while group 2 received patient controlled analgesia alone. There was a significant reduction in morphine consumption when local cooling was applied (18.6 mg versus 30.2 mg at 12 h, 29.0 mg versus 49.6 mg at 24 h, p < 0.05). Patients were also significantly more satisfied with their overall postoperative pain management when cooling therapy was used.

Adult↗
PubMed1994

Delayed postoperative paraplegia with hypotension in adult revision scoliosis surgery.

The clear and reversible relationship of spinal cord function to postoperative hypotension is illustrated in a case of revision scoliosis surgery in an adult patient. The correlation of spinal cord monitoring by both magnetic cortical motor evoked potentials and spinal somatosensory evoked potentials to the clinical status is shown, and the importance of close postoperative observation of the adult revision case is emphasized.

Adult↗
PubMed1994

Double-blind comparison of ondansetron, droperidol and saline in the prevention of postoperative nausea and vomiting.

We have compared the efficacy of ondansetron with droperidol and saline in the prevention of postoperative nausea and vomiting (PONV) in 120 ASA I and II patients undergoing hip and knee replacements and femoral resections. They received a standardized combined extradural and general anaesthetic and at the end of surgery were allocated randomly to receive droperidol 1.25 mg, ondansetron 4 mg or 0.9% saline in a 25-ml bag. An extradural mixture containing 0.5% plain bupivacaine 10 ml, fentanyl 500 micrograms and saline 30 ml was infused and PONV assessed for 24 h. Both ondansetron and droperidol were superior to saline in preventing vomiting (P < 0.01) although there was no significant difference between them. The incidence of vomiting was 17% for ondansetron, 18% for droperidol and 45% for saline. There was no significant difference in the incidence of nausea between the groups. Metoclopramide, the rescue antiemetric, was demanded by 38%, 34% and 17% of patients receiving saline, droperidol and ondansetron, respectively (ondansetron vs droperidol P < 0.05).

Adolescent↗
PubMed1994

A controlled trial of the effects of esmolol on cardiac function.

We have examined the effects of two different bolus doses of esmolol hydrochloride (Brevibloc) on haemodynamic variables in a placebo-controlled, double-blind, randomized trial. Sixty healthy adult patients undergoing minor orthopaedic surgery were given a standardized general anaesthetic using a laryngeal mask airway. Heart rate (HR), mean arterial pressure (MAP), stroke volume (SV) and cardiac output (Q) were measured (the latter two by Doppler ultrasonography) every 1 min for 5 min after injection of either placebo or esmolol 100 mg or 200 mg. HR, MAP, SV and Q decreased significantly (P < 0.05) for both esmolol groups compared with placebo and, except for MAP, esmolol 200 mg had a greater effect than esmolol 100 mg (P < 0.05). Depression was maximal at 2 min after which recovery was observed but was still incomplete at 5 min.

Adolescent↗