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Biomedical subjects

M Himori

Publications and source records attributed to M Himori.

7 recordsLinked to original sources
PubMed1997

Possibility of defense against colorectal tumor by foamy cells.

To investigate the difference between colorectal adenocarcinomas with white spots (foamy cells) and those without white spots, clinically and histopathologically, we examined 112 cases of colorectal adenocarcinomas in this study. Thirty-two cases were diagnosed as submucosal invasive adenocarcinoma and 80 as advanced adenocarcinoma. They were classified into two groups: with white spots and without white spots. Submucosal tumors and squamous epithelial-origin tumors were excluded. In each case we looked for evidence of lymph node and liver metastases. Immunoreactive staining for macrophages, foamy cells, T cells, and B cells was also performed. We found a significant difference in the incidence of lymph node metastasis between the two groups with advanced carcinoma. White spots (foamy cells) were present at some distance from carcinoma cells. We conclude that foamy cells might have a beneficial role. From a histopathological viewpoint they can be considered a possible physical defense wall, an index of immune response activation. Clinically, it is important not to overlook any lesion.

Adenocarcinoma↗
PubMed1996

Ki-67 and p53 immunoreactive stain and early colorectal neoplasms.

The aim of this work was to conduct a histopathological study of the different pathways of colorectal tumorigenesis by using Ki-67 and p53 immunoreactive stains. Between 1987 and 1993, 14,023 patients were investigated by colonoscopy at Akita Red Cross Hospital and several affiliated hospitals. Five hundred and sixty-five cases of early colorectal neoplasms identified in this population were used in the present study. Specimens were cut in half: one half was cut along the vertical axis, the other half along the horizontal axis to analyze the structure of glands which opened to the surface. They were stained with hematoxylin-eosin, Ki-67 and p53 immunoreactive stains. macroscopically, early colorectal neoplasms were classified into two types: protruding type and depressed type. The protruding type was mainly composed of branching glands. In contrast, the depressed type was almost completely composed of straight glands which opened to the surface. The Ki-67 positive ratio was almost equal. However, the p53 positive ratio was significantly different in the protruding type and the depressed type. The results suggest the existence of at least two pathways of colorectal tumorigenesis: one with the process of branching structure and one without the process of branching structure. Furthermore, there were clinical and immunohistochemical indications that the depressed type invades into deeper layers more rapidly than does the protruding type.

Adolescent↗
PubMed1995

p53 immunoreactive stain and early colorectal adenocarcinomas.

565 cases of early colorectal adenocarcinomas were used in this study to examine mechanisms of carcinogenesis. Specimens were paraffin embedded and histological sections were stained with haematoxylin-eosin and p53. Macroscopically, early colorectal adenocarcinomas could be classified into two types: protruding and depressed. The former were composed of branching glands, while the latter were composed of straight glands which opened to the surface. The p53 positive ratio was similar for protruding tumours but was higher in depressed submucosal invasive adenocarcinomas than in depressed intramucosal adenocarcinomas. These results raise the possibility of at least two pathways for colorectal carcinogenesis, adenoma-carcinoma lesions and de novo carcinoma lesions.

Adenocarcinoma↗
PubMed1994

Colorectal tumours and pit pattern.

AIMS: To investigate the morphological and histopathological associations between an individual pit seen on stereomicroscopy or magnifying colonoscopy and an individual crypt seen in histological sections; and to examine these associations in colorectal tumours. METHODS: Fourteen thousand and twenty three cases were examined by colonoscope at Akita Red Cross Hospital. The surface mucosal pits of the lesions were observed using a magnifying endoscope in vivo and the pits of the extracted specimens were observed in vitro using a stereo microscope. Histological diagnoses were determined by light microscopy: the pit patterns in 100 glands were analysed. RESULTS: Pit pattern was classified into seven principal types: (1) normal round pit; (2) small round pit; (3) small asteroid pit; (4) large asteroid pit; (5) oval pit; (6) gyrus-like pit; and (7) non-pit. There was a correlation between pit pattern and the structure of the underlying crypt or gland. Furthermore, there was an association between pit pattern and the histology of the cells in the gland. Macroscopically, types 3, 4, 5, and 6 were common in protruding lesions. Type 2 was common in depressed lesions. The non-pit pattern was recognised in both. The depressed lesions had invaded the deeper layers more rapidly than protruding lesions. CONCLUSIONS: There were associations between individual pits and crypts. The branching carcinoma gland is thought to be the result of malignant transformation of the adenoma gland. The straight carcinoma gland is thought to result from the normal gland becoming malignant. The gland of the small round pit is thought to change from normal to the straight carcinoma gland via malignant transformation.

Adolescent↗
PubMed1991

[A provisional serovar of Shigella dysenteriae isolated in Japan from travellers' diarrhea].

A bacterial strain was isolated that possessed the biochemical characteristics of Shigella dysenteriae but did not belong to any of the established S. dysenteriae serovars, from the feces of a diarrheal case who had travelled to Turkey, Pakistan, India and Thailand for about a month. This strain was invasive to tissue culture cells and gave a positive Serény test. Preparing antiserum against this strain and examining the antigenic relationship with the established O antigens of Shigella and Escherichia coli O1-O170, we found that the strain had O antigen identical to that of the E. coli O serogroups 150. The results indicated that this strain could be a provisional serovar of S. dysenteriae. Although our strain could probably be the same serotype as that of the strains reported in Israel, this may be the first report of isolation in Japan.

Adult↗
PubMed1991

[Enteroinvasive Escherichia coli O121: H- isolated from travellers' diarrhea].

A lactose slow-fermenting, non motile Escherichia coli strain was isolated from a diarrheal patient returning from Indonesia. Examination of virulence of the strain showed that it penetrated into tissue culture cells, and were positive in Serény test and enzyme-linked immunosorbent assay for detection of enteroinvasive E. coli. A large plasmid responsible for virulence was also detected. Thus the strain was confirmed to be a typical enteroinvasive E. coli. Analysis of O serotype using the antisera against E. coli O1-O170 revealed that the strain had O121 antigen, whose antiserum is not included in the commercial serotyping kit for the diagnosis of diarrheagenic E. coli.

Diarrhea↗