Synthesis and analgesic activity of morphine-7,8-oxide and heroin-7,8-oxide.
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Analgesics↗
Biomedical subjects
M Hirobe
Publications and source records attributed to M Hirobe.
Reaction of N-aminopyridinium derivatives. XIII. Syntheses of pyrazolodiazines by cyclization of N-aminodiazinium salts.
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Amination↗
[Reaction of qinazolines with hydroxylamine-O-sulfonic acid (author's transl)].
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Chemical Phenomena↗
[Reaction of N-aminopyridinium derivatives. XIV. Reaction of pyrazolo-diazines (author's transl)].
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Chemical Phenomena↗
[Direct detection of heroin in urine by means of mass fragmentography].
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Animals↗
[Studies on synthetic antimicrobials. I. Synthesis of pyridine-4-thiocarbonamide derivatives (author's transl)].
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Amides↗
[Reactions of N-aminopyridinium derivatives. XII. Nucleophilic reactions of N-aminopyridinium derivatives].
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Boron Compounds↗
[Reactions of N-aminopyridinium derivatives. IX. Syntheses of pyridine N-arylimines].
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Pyridinium Compounds↗
[Reactions of N-aminopyridinium derivatives. X. Nitration and oxidation with hydrogen peroxide of pyridine N-arylimine derivatives].
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Chemical Phenomena↗
[Reactions of N-aminopyridinium derivatives. XI. Reaction of N-benzylideneamino pyridinium salts with cyanide ion (a new synthesis of 5-aminooxazole derivatives)].
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Chemical Phenomena↗
[Reactions of N-aminopyridinium derivatives. 8. Reactions of N-aminopyridinium salt with aldehydes].
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Aldehydes↗
Reaction of n-aminopyridinium derivatives. 3. Synthesis of s-triazolo [1,5-a]-pyridine ring.
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Azoles↗
Reaction of N-aminopyridinium derivatives. IV. Syntheses of N-aminoquinolinium salts and their reaction with cyanide ion.
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Chemical Phenomena↗
Reaction of N-aminopyridinium derivatives. V. Syntheses of 1-(N-methylacetamido)alkylpyridinium salts and their reaction with cyanide ion.
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Chemical Phenomena↗
Reaction of N-aminopyridinium derivatives. VI. Properties of s-triazolo[1,5-a]pyridine ring.
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Azoles↗
Reaction of N-aminopyridinium salt with cyanide ion.
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Chemical Phenomena↗
High-performance liquid chromatography and fluorometric detection of arachidonylethanolamide (anandamide) and its analogues, derivatized with 4-(N-chloroformylmethyl-N-methyl)amino-7-N,N-dimethylaminosulp honyl-2,1 ,3- benzoxadiazole (DBD-COCl).
The endogeneous ligand for the cannabinoid receptor, arachidonylethanolamide (anandamide) and its analogues, oleinylethanolamide, palmitylethanolamide and eicosapentaenoylethanolamide, were derivatized with a fluorogenic reagent, 4-(N-chloroformylmethyl-N-methyl)amino-7-N,N-dimethylaminsulpho ny1-2,1,3- benzoxadiazole (DBD-COCl). They were separated on a reversed phase HPLC with a mobile phase of acetonitrile:water. The fluorometric detection of the derivatives was made at 560 nm with excitation at 450 nm and the detection limits for anandamide was 20 fmol on column. The structures of DBD-CO-ethanolamides were confirmed by liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry (LC-APCI-MS).
Arachidonic Acids↗
Identification and quantification of p-hydroxyethylamphetamine as a novel metabolite of ethylamphetamine in rat by gas chromatography-mass spectrometry.
Ethylamphetamine and two major metabolites in urine, obtained after intraperitoneal administration of the drug to rats, have been isolated by gas chromatography-mass spectrometry. We have also synthesized an authentic sample of p-hydroxy-N-ethylamphetamine by a simple method. In rat, the metabolic pathway of ethylamphetamine is similar to that of amphetamine and methylamphetamine according to quantitative analysis of the major metabolites using a selected ion monitoring (SIM) method.
Amphetamine↗