Oral hypoglycemic agents as an alternative therapy for gestational diabetes.
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Biomedical subjects
Publications and source records attributed to M Hod.
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We sought to determine whether external cephalic version (ECV) with tocolytic agents in term patients with breech presentation could safely reduce the incidence of breech-related cesarean sections and vaginal breech deliveries. Four hundred and thirty-two patients with breech presentation at term who fulfilled broad criteria for attempted ECV and a control group of 330 patients with breech presentation at term in whom ECV was not attempted, were retrospectively reviewed. ECV was attempted following an infusion of ritodrine hydrochloride, using either the back flip of Saling and Muller-Holve or the classic forward roll. Following successful ECV, an infusion of oxytocin was administered to fix the head in the pelvis. Of the 432 patients, 311 (72%) underwent successful ECV; 86% delivered vaginally. Cesarean sections were performed in 76% of the patients with unsuccessful ECV and in 64% in whom the version was not attempted (control group). We conclude that ECV at term, using tocolytic agents, when applied to a broad spectrum of patients, is a safe and useful procedure for reducing the incidence of breech presentation, and as a direct consequence, for reducing the incidence of cesarean sections.
Breech presentation is prevalent among preterm deliveries and contributes to neonatal mortality far beyond its prevalence. The management of a preterm breech delivery is controversial. We present our retrospective experience with 185 consecutive preterm breech deliveries, part delivered by cesarean section and part delivered vaginally as assisted breech delivery or total breech extraction), and compare the perinatal outcome between these two groups in terms of perinatal mortality (PPD) and perinatal morbidity (neonatal asphyxia). No statistically significant difference was found for either variable in the two examined groups. We therefore conclude that the method of delivery of low birth weight (1000-2500) breeches has no effect on perinatal outcome.
OBJECTIVE: To study the nature of a condition called transient osteoporosis of the hip (TOH) in pregnancy. METHOD: Fifty-three cases of this syndrome of unknown etiology have been reviewed and an additional case has been added. RESULT AND CONCLUSION: TOH is characterized by hip joint pain during the 3rd trimester of pregnancy and signs of demineralization of the femoral head. The course is benign with recovery shortly after birth. No specific therapy is required except bed rest.
Up until the early seventies fear of uterine rupture led to the widespread practice of 'once a section, always a section'. Nowadays, there is a consistent trend toward vaginal birth after a prior cesarean delivery, making early detection of uterine scar dehiscence at delivery important. However, the need for routine transcervical revision of the uterine scar following vaginal delivery is controversial in the medical literature. The present study reviewed 467 women who underwent vaginal delivery following a previous cesarean section. In 414 patients the scar was examined transcervically, and not one case of dehiscence of the scar was detected. The patients included four with twin pregnancies, and four with breech presentations (two underwent external cephalic version). Intrauterine pressure was monitored in 17 cases; Prostaglandin E2 vaginal tablets were used in 46 patients, and in 14 cases labor was augmented by Pitocin. Our results suggest that routine revision of a uterine scar at the time of a subsequent vaginal delivery is usually unnecessary.
During pregnancy, dilatation of the urinary collecting system is very common. Acute hydronephrosis is one of the most common causes of severe flank pain in pregnancy. Severe complications of hydronephrosis of pregnancy, such as pain, renal failure or a ruptured collecting system, occur very occasionally. A rare case of spontaneous rupture treated conservatively is presented.
Hyperemesis gravidarum is a common entity the cause of which has remained poorly defined. However, it probably is a classic example of the interplay between biologic, psychological and sociological variables. Current data on hyperemesis gravidarum and the pertinent literature for the last two decades are reviewed.
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Three cases of severe fetal bradycardia during labor following an air-raid alarm are described. After 2 min of severe bradycardia (less than 60 beats/min) the fetal heart rate (FHR) returned to a normal pattern. In all cases labor progressed uneventfully with an excellent fetal and maternal outcome. The cases are briefly described and possible causative mechanisms are discussed.
Minor congenital anomalies (MCA) were assessed in the offspring of 802 gestational diabetic mothers, 117 pre-gestational diabetic mothers, and 380 offspring born to normal mothers. The prevalence of infants with MCA ranged between 19.4% and 20.5% in the three groups without any significant difference between them. There was no correlation between the prevalence and type of MCA and the severity of the diabetic state. Neither was there any correlation between the prevalence or type of MCA and the appearance or type of major congenital anomalies.
Familial congenital pyloric atresia is a rare malformation of the fetal gastrointestinal tract. It usually manifests as maternal polyhydramnios and enlarged fetal stomach on ultrasound scan. Sonographic prenatal diagnosis and management of a pregnancy complicated by familial congenital pyloric atresia are presented.
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Maternal metabolic aberrations during pregnancy complicated by diabetes are responsible for profound changes in all aspects of fetal intrauterine development and, later, short-, and long-range implications on the neonate and the child. In this article we review the evidence that has been accumulated in the literature linking the aberrant fuel mixture and fetal hyperinsulinemia to the long-range neonatal and childhood complications of the offspring of the diabetic mother.
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Glycogen content and the enzymes of glycogen metabolism have been measured in the postimplantation rat embryo over a period ranging from 9.5 to 18.5 days of gestation. The earliest periods studied were at days 9.5 and 10.5 of gestation, when the yolk sac becomes vascularized and heart beat is first established. The next intervals were at days 10.5-11.5 when vascular connections via the allantoic placenta are formed. At 14.5 and 18.5 days of development, 4 entire organs were analyzed; heart, liver, kidney and brain. The metabolic apparatus of glycogen metabolism was concentrated in the embryo at 10.5 days, then the heart region, and in the heart itself at later stages.