Biomedical subjects
M Hodge
Publications and source records attributed to M Hodge.
Maxillary sinusitis from dental osseointegrated implants.
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Postdysenteric reactive arthritis. A clinical and immunogenetic study following an outbreak of salmonellosis.
Following an outbreak of foodborne gastroenteritis caused by Salmonella typhimurium, questionnaires were sent to affected individuals and then to the family physicians of any who experienced extra-enteric complications. Of 260 individuals infected with S typhimurium for whom adequate data were obtained, 19 patients developed joint disease (7.3%). All were men; the mean age +/- SD was 39.3 +/- 1.6 years. Among the 16 patients for whom this information was available, the interval from the onset of diarrhea to the onset of joint pain was less than 7 days in 7, 8-21 days in 2, and greater than 21 days in 7. There was a significantly longer duration of diarrhea in those patients with joint disease (mean +/- SEM 15.2 +/- 2.6 days) than in those without complications (10.0 +/- 1.1 days) (P less than 0.01). The joint disease was monarticular in 3 patients and polyarticular in 16. The joints most commonly affected were the elbow (47%), wrist (47%), knee (42%), low back (32%), and shoulder (32%). Six of the 19 patients had at least 1 extraarticular feature: ocular (5 patients), mucosal (1 patient), urethral (2 patients), or cutaneous (1 patient). Of these 19 patients, 11 were located and agreed to HLA typing. Four were positive for HLA-B27, 6 were HLA-B7 positive, and 1 had HLA-Bw60. Of the 4 B27 positive patients, 3 were DR1 positive; of the 6 B7 positive patients, 5 were DR2 positive.(ABSTRACT TRUNCATED AT 250 WORDS)
The acoustic signature for intelligibility test words.
As part of a research program that aims to develop an explicit acoustic basis for a single-word intelligibility test, an initial attempt to characterize the formant trajectories and segment durations of seven test words produced by 30 normal speakers is described. These characterizations are referred to as "acoustic signatures." The data indicate that: (1) formant trajectories show two sex effects, namely, that females are more variable as a group than males and tend to have greater slopes for the transitional segment of the second-formant trajectories and that these effects are consistent across words; (2) Bark transformations of the frequency data do not seem to eliminate the interspeaker differences in formant trajectories, nor do they eliminate either of the sex effects described above; and (3) segment durations have different variabilities depending on the syllabic structure of the word; no sex effect was noted here. The discussion focuses on the appropriate form for the acoustic signatures, as well as factors that should be considered in selecting words for signature development. To demonstrate the potential application of these data, formant trajectory and segment duration data from 18 speakers with amyotrophic lateral sclerosis and varying degrees of dysarthria are compared to the acoustic signature for the word wax.
Arthritis, vasculitis, and cryoglobulinemia associated with relapsing hepatitis A virus infection.
Hepatitis A virus, unlike hepatitis B virus, has rarely been associated with extrahepatic features. Two patients developed relapsing hepatitis A complicated by arthritis in both cases and cutaneous vasculitis in one. Both patients had cryoglobulinemia, with cryocrit values of 4.3% and 8.6%. Serologic studies showed that the cryoglobulin consisted of polyclonal IgM and IgG. The washed cryoglobulin was analyzed by sucrose density gradient ultracentrifugation under neutral (pH 7.4) and acidic (pH 2.8) conditions. Enzyme-linked immunosorbent assay techniques were used to characterize the native and dissociated cryoglobulin. The cryoglobulin contained acid-dissociable IgG complexes greater than 19S, and high molecular weight rheumatoid factors of both IgG and IgM isotypes that could be dissociated to 7S and 19S forms, respectively. Dissociation of the cryoglobulin augmented 7S anti-hepatitis A virus IgG 2.27-fold, but augmented total 7S IgG only 1.12-fold, suggesting enrichment of antiviral antibody in the cryoglobulin.