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Biomedical subjects

M Hollander

Publications and source records attributed to M Hollander.

32 records · Page 2Linked to original sources
PubMed1983

Acquired immunodeficiency with reversed T4/T8 ratios in infants born to promiscuous and drug-addicted mothers.

A new syndrome of acquired immunodeficiency has been identified in seven children who were small for gestational age at birth and subsequently have exhibited failure to thrive, lymphadenopathy, parotitis, hepatosplenomegaly, interstitial pneumonia, and recurrent infections. All have a profound cell-mediated immunodeficiency with reversed T4/T8 ratios. Six are hypergammaglobulinemic and one has low IgG levels. The mothers of five of the seven children are sexually promiscuous and/or drug addicts. Three mothers have an immunodeficiency similar to that found in their infants. One of them died at age 33 years with a diagnosis of acquired immunodeficiency syndrome. In five of the children and in three of their mothers, there is evidence of a persistent Epstein-Barr virus (EBV) infection. We speculate that a perinatal or in utero transmission of EBV can induce an "infectious immunodeficiency." The clinical, histopathologic, and immunologic features resemble those described in adult homosexuals and drug addicts.

Acquired Immunodeficiency Syndrome↗
PubMed1983

Tests for monotone mean residual life, using randomly censored data.

At any age the mean residual life function gives the expected remaining life at that age. Reliabilists and biometricians have found it useful to categorize failure distributions by the monotonicity properties of the mean residual life function. Hollander and Proschan (1975, Biometrika 62, 585-593) have derived tests of the null hypothesis that the underlying failure distribution is exponential, versus the alternative that it has a monotone mean residual life function. These tests are based on a complete sample. Often, however, data are incomplete because of withdrawals from the study and because of survivors at the time the data are analyzed. In this paper we generalize the Hollander-Proschan tests to accommodate randomly censored data. The efficiency loss due to the presence of censoring is also investigated.

Analysis of Variance↗
PubMed1975

Multiple births in drug-addicted women.

Two sets of twins and two sets of triplets were delivered in a group of 126 pregnant drug addicts. The over-all multiple-birth incidence of 1:32 is three times more prevalent than that found in the general population. Three of the four multiple births were dizygotic. The mothers with the dizygotic multiple births were on moderate to elevated levels of heroin or methadone at the time of conception. Mechanisms are presented to help explain why narcotics may cause supraovulation and multiple births.

Adult↗
PubMed1975

Micro-scale blood lead determinations in screening: evaluation of factors affecting results.

The Delves micro-scale technique for blood lead analysis is an accurate method for screening capillary blood specimens, obtained by fingerstick, for lead intoxication. Results are affected by the age of cup, loop, and hollow-cathode tube and by the spatial relationship between optical tube and cup. Because the glass in many commercially available capillary tubes (used in specimen collection) contains lead and cannot be decontaminated, a lead-free glass tube must be used. A solution of citric acid in ethanol (20 g/liter) effectively cleanses the puncture site. A double-blind study of 207 specimens gave a mean value of 276.6 plus or minus 105.8 mug/liter (1SD) for the micro-scale method vs. 273.2 plus or minus 99.0 for a macro-scale method. The mean coefficent of variation for the micro-scale method was 5.75 percent plus or minus 1.9 (SD). We conclude that values of 480 mug/liter or below are not "toxic" (i.e., are significantly less than 600 mug/liter, the value at which therapy is begun). The method is shown to be satisfactory as a screening procedure and for confirming lead analyses done by other methods.

Adult↗
PubMedDate not supplied

Renal transplantation in the elderly--the Irish experience.

BACKGROUND: The aim of this paper was to evaluate patient and kidney graft survival rates in renal transplant recipients and compare the outcomes between the different patient age groups. METHODS: A retrospective review of all adult renal transplants performed at Beaumont Hospital between the years 1986-2001 was carried out. Patients were defined as 'elderly' if they were 65 years of age or older and 'younger' if less than 65 years at the time of transplantation. Patient and transplant graft survival rates were analysed for each age group. RESULTS: Data were analysed on 1462 'younger' patients and 105 'elderly' renal transplant recipients. Estimated patient survival at 1, 5 and 10 years were 96%, 87% and 74% in the younger patient group compared to 85%, 59% and 33% in the elderly group. The adjusted graft survival rates (adjusted for death due to other causes and with a functioning graft in situ) for the younger group were 89%, 77% and 64% at one, five and ten years respectively, while for the elderly group, adjusted one, five and ten year survival rates were 89%, 83% and 70% respectively. CONCLUSIONS: Although the elderly have a shorter life expectancy than the younger population they do benefit from renal transplantation similar to the younger recipients.

Age Factors↗
PubMedDate not supplied

Investigation of healthcare providers' patterns of referring breast cancer patients to Reach to Recovery.

Providers who referred patients to Reach to Recovery (Reach), an American Cancer Society breast cancer support group, were compared with those who did not to evaluate whether providers who identified problems with the program were less likely to make referrals. Also considered were contact with a Reach volunteer, having a Reach program in the area, years since residency or medical training, perceived value of the Reach program, belief that one's peers refer patients to Reach, urban or rural location of practice, and size of practice. When other variables were considered, physicians who identified problems with Reach were no less likely to refer patients to the program than those who did not. The factors most associated with referral (P < .001) were "having a Reach program in the area" and "having had contact with a Reach volunteer." Implications of these findings and the experience of conducting the evaluation through the Collaborative Evaluations Fellows Project are discussed.

Breast Neoplasms↗