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Biomedical subjects

M Holzmann

Publications and source records attributed to M Holzmann.

At least 19 recordsLinked to original sources
PubMed1992

Circadian variation of the phagocytic activity of polymorphonuclear leukocytes and of various other parameters in 13 healthy male adults.

Twenty-four different laboratory parameters including the phagocytic activity (phagocytic index) of polymorphonuclear leukocytes (PMNs) and various hematologic variables were investigated in 13 young healthy men during Spring 1988 in Munich, Germany. Venous blood of these volunteers was obtained under standardized conditions at 4-h intervals over a 24-h span. All parameters were analyzed by the single cosinor method and by a Kruskal-Wallis analysis of variance (ANOVA). Statistically significant circadian rhythms were found for the number of circulating lymphocytes and leukocytes (WBCs), potassium, systolic blood pressure, phagocytic index, Quick test, heart rate, and rectal body temperature (p less than 0.05; single cosinor). For all of these parameters except WBCs, rectal body temperature, and Quick test, a temporal variation was confirmed by the ANOVA (p less than 0.05; phagocytic index: p = 0.05). The circadian acrophases of WBC, number of circulating lymphocytes, and phagocytic index were all found at about 01:00 h. This temporal coincidence of the acrophases of the phagocytic index and the number of circulating lymphocytes may reflect the modulation of phagocytosis by T lymphocytes that release cytokines known to stimulate the phagocytic activity of PMNs.

Adult↗
PubMed1978

In vivo vs in vitro response time of trancutaneous PO2 electrodes. A comparison of four devices in newborn infants.

Four devices for transcutaneous PO2 (tcPO2) monitoring have been applied simultaneously in 16 infants. Both during a maximal change in PaO2 and during physiological PO2 variations, the in vivo response time of the electrodes did not show the differences observed in vitro. We compared A, a prototype of the electrode by Huck, Lübbers and Huch (25 micrometer Telfon membrane) ; B, the commercial version of A by Hellige--Draeger (25 micrometer Telfon); C, the Radiometer TCM I oxygen monitor (25 micrometer polypropylene); and D, the Roche macrocathode electrode (6 micrometer Mylar), at 44 degree C. In vitro the 50% response times were 2.9 (A), 4.4 (B), 3.7 (C), and 7.4 (D) sec. The rates of tcPO2 changes at the midpoint of the response curves were 3.8(A) 2.0 (B), 3.0 (C), and 1.7 (D) kPa/sec. In vivo during a sudden change from hyperoxemia (FIO2 1.0) to normoxaemia the respective rates were 0.6 (A), 0.8 (B), 1.1 (C), and 1.0(D) kPa/sec. The in vivo 50% response times were 53.3 (A), 51.1 (B), 46.2 (C) and 45.3 (d) kPa/sec. The in vivo 50% response time were 53.3 (A), 51.1 (B), 46.2 (C), and 45.3 (d) kPa/sec. The in vivo 50% resonse time were 53.3 (A), 51.1 (B), 46.2 (C), and 45.3 (D) sec. The lag time between PaO2 and tcPO2 was about one third of this overall response time. The response to more physiological variations of PaO2 (periodic breathing) was not different among the tested electrodes in terms of damping and of delay of the tcPO2 deflections. In a steady state the correlation of tcPO2 44 degree C vs PaO2 was close (r = 0.98) with all devices up to 6.1 kPa (456 torr).

Blood Gas Analysis↗
PubMed1978

Skin oxygen permeability in premature infants.

While 24 newborn infants (ages, 2 to 48 hours; gestational ages, 24 to 42 weeks) breathed various concentrations of oxygen, the PO2 values on their unheated skin surface were measured by an unheated microcathode electrode for transcutaneous PO2 monitoring. In infants with arterial PO2 values in the range of 50 to 100 torr and with similar skin temperatures, the mean surface PO2 of unheated skin was inversely related to birth weight: 27.2 torr in infants weighing less than 1,500 gm, 14.3 torr in infants weighing 1,500 to 2,500gm, and 2.9 torr in infants weighing more than 2,500 gm. In the smallest infants, the skin surface PO2 was significantly related to arterial PO2: it was about one third of arterial PO2 as estimated by a second electrode for transcutaneous PO2 monitoring heated to 44 degrees C. Phototherapy, crying, or blood transfusion increased the surface PO2 of unheated skin, but not the tcPO2 measured at 44 degrees C. These findings suggest that blood flow to the skin in excess of its metabolic needs due to immature control of cutaneous circulation, along with low resistance to oxygen diffusion, determines the high oxygen permeability of skin in premature infants.

Birth Weight↗
PubMed1975

[Left atrial parasystole].

A case of atrial parasystole is described in a 55-year-old female with multivalvular heart disease, treated with high doses of digitalis and showing first-degree av block. The left atrial origin of the parasystolic P waves was supported by their distinctive morphology, especially in lead V1, and the sequence of left and right atrial activation. Depending on the refractory state of the myocard, there was a greater shortening of the av conduction time during the parasystolic discharge than during sinus beats indicating a caudal localization of the parasystolic center.

Arrhythmias, Cardiac↗