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Biomedical subjects

M Hotchi

Publications and source records attributed to M Hotchi.

At least 55 records · Page 3Linked to original sources
PubMed1986

[An autopsy case of anaplastic carcinoma of the thyroid gland with primary empty sella and marked atrophy of the adrenal glands].

The patient was a 67-year-old woman, she had lost her public and axillary hair upon menopause at the age of 47, and symptoms of hypothyroidism appeared with cervical tumor one year prior to her death. A diagnosis of anaplastic carcinoma was made by biopsy of the thyroid gland. Laboratory examination revealed a high titer of antithyroid antibody and dysfunction of the thyroid gland, adrenal cortices and pituitary gland. At autopsy, the pituitary gland showed a cup-shaped deformity with atrophy, and the adrenal glands were markedly atrophic. It was considered that the atrophy of the adrenal glands was secondary to dysfunction of the pituitary gland.

Adrenal Cortex↗
PubMed1985

Polyclonal plasma cell proliferation with systemic capillary hemangiomatosis, endocrine disturbance, and peripheral neuropathy.

An autopsy case of so-called plasma cell dyscrasia (PCD) of a 37-year-old woman was reported. This case showed typical clinical symptoms of PCD, except for no abnormality in serum immunoglobulins. Besides the typical histological findings often observed with PCD, the autopsy revealed an additional finding of systemic angiomatous proliferation of small blood vessels throughout the body, especially in the skin, kidneys, brain, various lymph nodes, and soft tissue. A peculiar glomerular lesion in this case, similar to membranoproliferative glomerulonephritis, was likely to be a result of proliferation of glomerular capillaries. In addition, this case showed histological evidence of retroperitoneal fibrosis and osteosclerosis. These findings were also considered to be due to the vascular abnormality. Although the etiology of the vascular lesions is obscure, it is emphasized that the abnormality is probably an important cause of the clinical symptoms seen in PCD.

Adult↗
PubMed1985

[An autopsy case of primary malignant melanoma of the ovary].

This report presents the first patient in Japan with primary malignant melanoma of the ovary. The patient was a 62-year-old woman with the complaint of progressive left hemiparesis due to metastatic brain tumor. She died in the course of two months. At autopsy, there was a large tumor containing brownish fluid at the right ovary. The inner lining of the tumor was covered with a black friable mass with hairs. Histologically, the tumor was composed of polygonal, melanotic or amelanotic cells. Metastases were found in the cerebrum, uterine cervix, etc. In conclusion, the tumor was thought to be malignant melanoma arising in a dermoid cyst. This is an extremely rare condition, reported in only 12 cases throughout the world. The histological findings and histogenesis are presented and discussed.

Brain Neoplasms↗
PubMed1983

Histochemical application of mild alkaline hydrolysis for selective elimination of O-glycosidically linked glycoproteins.

A new technique to eliminate O-glycosidically linked glycoprotein (mucin-type glycoprotein) selectively has been developed. Composite paraffin sections were collodionized before and after alkaline treatment with 0.5 M NaOH in 70% ethanol; the effect of this procedure on mucosubstances was examined using the periodic acid-Schiff reaction. Exposure to alkaline hydrolysis for 72 to 144 hours at 4 C led to a complete loss of periodic acid-Schiff reactivity of epithelial mucins in rat sublingual gland, stomach and small intestine, but that of fuzzy coat, thyroid colloid, collagen fibers and tracheal cartilage was well preserved. These results agreed fairly well with biochemical findings. The present study also revealed that materials prepared by freeze-substitution provided the most satisfactory results.

Animals↗
PubMed1980

Chronic granulomatous disease associated with peculiar Aspergillus lesions. Patho-anatomical report based on two autopsy cases and a brief review of all autopsy cases reported in Japan.

Chronic granulomatous disease (CGD) is based on the dysfunction of phagocytes and characterized by a comparatively uniform granulomatous lesion caused by organisms which do not produce hydrogen peroxide and which are catalase-positive. This report describes two autopsy cases in children, a nine year-two month-old boy and a ten month-old girl, with the clinical manifestations and autopsy findings of CGD and a brief review of all autopsy cases consistent with CGD reported in Japan. In these cases, in addition to the usual CGD lesions, there was a markedly different type of granuloma due to Aspergillus sp., which consisted of multinuclear giant cells alone, or a caseous center surrounded by giant cells. This peculiar type of aspergillosis may correspond to a primary infection, described as pseudotuberculosis aspergillina. It appears that in some CGD patients, macrophages may function normally and sometimes be more activated by these infections than in the normal body. The histochemical and electron microscopic examination of the present cases and a review of the previous cases suggest that the yellowish brown pigment found seems to resemble a ceroid. It is a product of the degradation of leukocytes and tissue elements with subsequent accumulation in phagocytic histiocytes and is not necessarily peculiar to CGD.

Aspergillosis↗
PubMed1980

Present state of fungal infections in autopsy cases in Japan.

In order to clarify the present state of opportunistic fungal infections increasing in incidence in autopsy cases, all autopsy cases from 1966 to 1975 reported in the Annual of Pathological Autopsy Cases in Japan were reviewed. Of the total 233,130 autopsy cases, mycoses were present in 4,340 (1.86%). The incidence of mycoses has strikingly increased during the recent five-year period. In Japan, the mycoses most frequently occurring in autopsy cases were candidiasis (32.28%), aspergillosis (23.08%), cryptococcosis (9.63%), and mucormycosis (2.90%). These occurred more frequently in younger persons and were most commonly secondary and deep-seated infections (95.78%). Among the primary diseases associated with mycoses, aplastic anemia (14.36%), leukemia (9.89%), malignant lymphoma (5.73%), multiple myeloma (4.68%), and systemic lupus erythematosus (4.62%) were most frequent. The incidence of the primary diseases associated with mycoses is increasing extraordinarily, and this seems to be strongly related to the modern therapy of using high doses of anticancer or immunosuppressive agents.

Adolescent↗