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Biomedical subjects

M Hoyle

Publications and source records attributed to M Hoyle.

21 records · Page 2Linked to original sources
PubMed1977

Small bowel ischaemia and infarction in young women taking oral contraceptives and progestational agents.

Case histories of three young women who suffered small bowel infarction associated with oral contraceptives and progestational agents are presented. Two infarctions were due to superior mesenteric artery thrombosis and one to superior mesenteric vein thrombosis. All of these patients were of blood group A and smokers, factors which are known to predispose to vascular thrombosis. A study was made of 18 additional cases reported in the literature. It was found that many of these cases presented with a history of symptoms of 2 weeks of more and at operation some of the cases appeared to be reversible. One case was reported where apparent reversion of the process of vascular thrombosis occurred after cessation of the oral contraceptive.

Adult↗
PubMed1977

Human fibroblast conditioned media contains growth-promoting activities for low density cells.

Normal diploid human fibroblasts, cultured at high density (1-2 X 10(5) cells per cm2) release two growth promoting activities into the culture medium. The fibroblast proliferation activity-conditioned medium facilitates the attachment of low density cells to the substrate. The activity resides in a non-dialyzable material that is sensitive to proteolytic inactivation. A second activity is dialyzable and can be recovered in the dialysate. In the presence of serum it stimulates cell growth. After 168 hours of incubation conditioned medium cultures contain five times more cells than are present in comparable cultures without conditioned medium. A reproducible biological assay for each activity is described.

Blood↗