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M Hroch

Publications and source records attributed to M Hroch.

At least 19 recordsLinked to original sources

[Induced cell fusion in a heteroploid cell line].

Non-uniformity in properties of the cells within the stabilized heterocaryonic line is certified by the decrease in capacity of the cells to fuse together after repeated influence of polyethylene glycol. Multiple and large polycaryonic formations resulting from primary administration of fusogen are relatively rapid in extinction. The cells having been survived after repeated administration of polyethylene glycol appear to fuse predominantly into less extended polycaryocytes with smaller multiplicity. This fact may be a consequence of the selection of a portion of non-uniform cell population being more susceptible to this fusogen. Those concerned are probably the cells rather different in surface qualities and/or adjacent parts of cytoskeleton.

Cell Fusion

[Induced cell fusion in the contact zone of cells with affected and unaffected surfaces. I].

The change in capacity of the cell fusion stimulated with polyethylenglycol is applied as a criterion of accumulation of noxiously transformed properties of cell surfaces. Similar changes are induced with substances employed as follows: chinuclidyl benzilate, atropiniumsulphate, tetrahydroaminacridine. The dynamics of releasing these substances is also tracked by dynamics of fusions capacity. In the area of contact of cells both noxiously influenced and uninfluenced, the decrease in capacity of fusions is also observed. At least a part of toxical substance is so released outside the cells. The former is then linked to the surfaces of unfluenced cells. This is an example of transfer of substance linked with the cell surface which is concerned.

Atropine