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M Hubert

Publications and source records attributed to M Hubert.

64 records · Page 4Linked to original sources
PubMedDate not supplied

[Hepatitis B vaccine: characterization of the polypeptides of hepatitis B surface antigen (author's transl)].

In order to realize a new kind of hepatitis B vaccine, the polypeptide components of the outer-coat of the hepatitis B virus have been studied. The characterization of the polypeptides of purified hepatitis B surface antigen (HBsAg) was performed by SDS-polyacrylamide gel electrophoresis. Seven polypeptides were observed, designated P1 to P7, according to their increasing molecular weight: P1 (MW = 24,000), P2 (MW = 32,500) and P6 (MW = 78,000) represented the major components. When the reducing action was increased and followed by alkylation and citraconylation, a single polypeptide of low MW (5,000 less than MW less than 10,000) was isolated from HBsAg.

Electrophoresis, Polyacrylamide Gel↗
PubMedDate not supplied

Evaluation of effects of terbinafine on single oral dose pharmacokinetics and anticoagulant actions of warfarin in healthy volunteers.

STUDY OBJECTIVE: To evaluate the potential effects of oral terbinafine, a new synthetic antifungal agent of the allylamine class, on the pharmacokinetics and pharmacodynamics of racemic warfarin. DESIGN: Randomized, double-blind, placebo-controlled, crossover study. SUBJECTS: Sixteen healthy men. INTERVENTIONS: Placebo or terbinafine 250 mg was administered once/day for 14 consecutive days, separated by a washout period lasting at least 2 weeks. A single oral dose of racemic warfarin 30 mg was coadministered with placebo or terbinafine on day 8 of each treatment period. Blood samples were collected for 168 hours after administration of warfarin to determine the drug's pharmacokinetics and anticoagulant effects. MEASUREMENTS AND MAIN RESULTS: No major differences were seen in the plasma concentration-time profiles of a single dose of warfarin administered with terbinafine or with placebo. CONCLUSIONS: Because of the lack of clinically significant interactions between terbinafine and warfarin during multiple-dose administration of terbinafine, no adjustment of warfarin dosage during concomitant therapy appears to be necessary.

Adult↗