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Biomedical subjects

M Hudec

Publications and source records attributed to M Hudec.

At least 37 records · Page 2Linked to original sources
PubMed1983

The prognostic relevance of various factors at the time of the first admission of the patient. Retrospective DOSAK study on carcinoma of the oral cavity.

In a retrospective study, on a sample of 1021 patients with carcinoma of the lips, oral cavity and oropharynx, the clinically available factors at the time of the patient's first admission are analysed with reference to their prognostic relevance. Prognostically relevant factors are determined by both univariate and multivariate analyses. Of the 18 factors analysed, the following seven finally proved to be prognostically relevant: tumour size, degree of infiltration, degree of histological differentiation and site by organ of the primary tumour, the combination of evidence + clinical appearance + degree of fixation of the regional lymph nodes, age of the patient, and evidence of distant metastases. On the basis of these results it will be possible to create a prognostic index. This prognostic index should be eligible for use in clinical practice, as opposed to usual classification models.

Adult↗
PubMed1983

[Retrospective DOSAK study of oral cavity carcinomas. Results and consequences].

In a multicentric, retrospective observational study on carcinomas of the oral cavity including the lips and the oropharynx a data material of 1021 patients has been analyzed. The specific goals of this study were: Review of existing proposals for classification; Analysis of prognostically relevant factors of the tumor disease; Construction of a prognostic index for the determination of individual and collective prognoses. The following results were gained: None of the TNM-classifications of oral cavity carcinomas does the necessary criteria justice not even approximately. The multivariate analyses of prognostically relevant factors were performed with and without taking therapeutical factors into account. The results unequivocally show that reliable prognoses are only possible under consideration of various treatment modalities. This led to the construction of the treatment-dependent prognostic index TPI, which will be eligible for the use within the clinical-therapeutical cancer research and within the clinical practice.

Analysis of Variance↗
PubMed1977

[Various causes of breakage of osteosynthetic material].

The authors in their work present some of the most common causes in breakage of osteosynthetic material. They emphasise the quality of the material is mainly satisfactory but the material should be from the same factory. Exhaustion of the material and corrosion are two of the common causes of the osteosynthetic material breakage. However uncorrect application and errors during the operation are the most common causes of breakage. The mechanical differences of the intramedullar nail and plate as two of the most used materials and their influences are explained. The most common errors which appear during the performance of opperation are explained to.

Biomechanical Phenomena↗
PubMed1976

[Criteria for evaluating calcium carbonate from the point of view of chlortetracycline biosynthesis].

Calcium carbonate is added to fermentation media in biosynthesis of tetracyclines for providing definite pH values and binding tetracycline into insoluble complexes. Seven different samples were studied with respect to their physical properties, such as the microscopic size of the particles, their form, capacity for agglomeration, specific volume, rate of the particle precipitation and chemical properties, such as purity, buffer capacity, effect on the medium pH before and after sterilization. The above properties were studied in comparison with activity chlortetracycline biosynthesis. Microfine calcium carbonate proved to be the best from the point of view of productivity of Str. aureofaciens. With its use the activity of the culture fluid increased by 20 per cent as compared to the other samples. The titration curve of the sample had the lowest bend.

Calcium Carbonate↗
PubMed1975

Absorption of the impact energy in the palmar soft tissues.

In 30 anatomical specimens of the forearm the dynamic fracture of radius has been performed with a special hammer. In these specimens the pure kinetic energy of the fracture of the radius and the absorption of the impact energy in the palmar soft tissues has been determined.

Absorption↗
PubMedDate not supplied

Fitting regression models to censored survival data.

A short review of regression models for the analysis of censored survival data is given. These include multiplicative hazard rate models, log-linear models (accelerated failure time models), linear models and polynomial models. An application of some of these models to the analysis of a large retrospective study on carcinomas of the oral cavity is described. The results obtained by parametric and semiparametric analyses are compared.

Aged↗
PubMedDate not supplied

[Critical evaluation of the treatment-dependent prognosis index TPI based on the "prospective DOSAK study on squamous cell carcinomas of the lips, oral cavity and oropharynx"].

The "Treatment Dependent Prognostic Index" (TPI), which has been published by the authors in 1982 as a result of a retrospective observational study of the DOSAK (German-Austrian-Swiss Association for Head and Neck Tumors), is submitted to a critical review. For this purpose a sample of 1485 patients representing the "Prospective DOSAK-Study on Squamous Cell Carcinomas of the Lips, the Oral Cavity and the Oropharynx" were classified according to TPI. 13 TPI groups exhibited greater than or equal to 20 patients and were suitable for calculation of observed survival and comparison to their TPI prognoses. In 10 of 13 TPI groups observed and predicted survival are almost identical. 3 TPI groups show a considerable lack of correspondence between observation and prognosis. In general, the analyses revealed a high prognostic validity of TPI in its substantial parts. A further improvement of TPI by taking several tumor sites into consideration seems possible and will be a subject of future investigations.

Carcinoma, Squamous Cell↗