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Biomedical subjects

M Huerta

Publications and source records attributed to M Huerta.

58 records · Page 4Linked to original sources
PubMedDate not supplied

Forskolin versus sodium cromoglycate for prevention of asthma attacks: a single-blinded clinical trial.

To determine the efficacy of forskolin in preventing asthma attacks, we performed a single-blinded clinical study in children and adult out-patients at a public hospital in Mexico. Forty patients of either sex with mild persistent or moderate persistent asthma were assigned randomly to 6 months of treatment with forskolin at 10 mg/day orally (capsules) or with two inhalations of sodium cromoglycate every 8 h, i.e. three times a day. The number of patients who had asthma attacks during the treatment period was significantly lower among those receiving forskolin (8/20, 40%) than among those receiving sodium cromoglycate (17/20, 85%). Values of forced expiratory volume in 1 s and forced expiratory flow, mid-phase, A similar in the two groups during the treatment period. We conclude that forskolin is more effective than sod cromoglycate in preventing asthma attacks in patients with mild persistent or moderate persistent asthma.

Adolescent↗
PubMedDate not supplied

[Efficacy of clopidogrel as ADP-dependent platelet aggregation inhibitor. Study on individuals with coronary artery disease].

Acetyl-salicylic acid inhibits thromboxane A2 production and reduces the risk of vascular occlusive events by 20 to 25%. Ticlopidine inhibits ADP-dependent platelet aggregation and reduces the same risk by 30 to 35%, but produces some adverse effects. Clopidogrel is a ticlopidin-derived antiplatelet-drug, with the same mechanism of action; reduces the expression of the glycoprotein IIb/IIIa, the fibrinogen receptor on the platelet surface. Clopidogrel has the same clinical efficacy of ticlopidin and lowers the incidence of adverse effects. In this study, we evaluated the effects of one daily dosis of 75 mg of clopidogrel on platelet function in 33 subjects with coronary artery disease. Before treatment and after the 6th and 12th week, the following parameters were evaluated: 5 microM-ADP and 20 micrograms/mL collagen-induced platelet aggregation, bleeding time and fibrinogen concentration. In basal and in the 6th and 12th week samples, ADP-induced platelet aggregation was 90.7% +/- 13.2, 54.6% +/- 23.2 and 49.2% +/- 23.7 respectively, that represents a significant reduction of 38.6% and 44.4%. Reduction of collagen-induced platelet aggregation was not significative. Plasmatic fibrinogen did not suffer variation during treatment. Bleeding time was significant prolonged from 4.1 minutes to 15.4 and 14.6 minutes (3.7-3.5 times compared with the test before treatment). There were no haemorrhagic complications, only digestive discomfort in fewer than 3% of patients. We concluded that clopidogrel is a safe and efficacious drug for patients, it efficiently reduces ADP-induced platelet aggregation and prolongs bleeding time.

Adenosine Diphosphate↗
PubMedDate not supplied

[Hematological differences between the effects of roller vs, centrifugal pump].

A secondary complication in the utilization of the CPB (cardiopulmonary bypass) is post-op bleeding due to alterations in the red blood cells and the activation sequences between coagulation, fibrinolysis and complement. We did this study with the objective to evaluate the behavior of the blood cells and coagulation factors using centrifugal pump (n = 12) roller pump (n = 12); we evaluated the consumption of blood products as well as measuring the amount of blood products used. There were no demographic differences between the two groups, the time on CPB was less than 85 minutes, blood flow in the centrifugal pump was maintained at an average of 3.6 l Vs 3.37 l in the roller pump, this being statistically significant. The blood values were compared in each group there were no statistically significant differences, however factor VIII, fibrinogen and platelets presented a tendency (p < 0.05) to be higher in the centrifugal pump group than in the control group (roller pump). Thus 1. In patients in whom we used centrifugal pump there was a tendency for preservation of factor VIII, platelets and fibrinogen. 2. There was no significant difference in the number of blood units transfused between the centrifugal vs roller pump. 3. patients in the centrifugal group were better perfused during CPB.4. 24 hrs. post-op, both groups showed no difference in post-op bleeding.

Adult↗