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Biomedical subjects

M Huffman

Publications and source records attributed to M Huffman.

10 recordsLinked to original sources
PubMed2001

Quantitative analysis of dimethyl titanocene by iodometric titration, gas chromatography and NMR.

In this study we report the use of an automated iodometric titration method and a novel gas chromatography (GC) method for the quantitative analysis of dimethyl titanocene (DMT), a key raw material in drug synthesis. Both approaches are based on the reaction of DMT in toluene or tetrahydrofuran solutions with iodine. In the case of iodometric titration, excess iodine is titrated with a standardized aqueous sodium thiosulfate solution to a potentiometric end-point for the determination of DMT concentration. Alternatively, GC is employed to measure the concentration of iodomethane, a product of the reaction between DMT and iodine, in order to determine the concentration of DMT in the solution. Excellent agreement between iodometric titration, GC and NMR results using several DMT samples confirms the accuracy of the two methods and strongly supports the use of either method as a replacement to the expensive NMR for quantitative DMT analysis. The relatively few sources of error associated with the two methods, their ubiquitous nature and ease of application in routine analysis make them the analytical methods of choice, among all. Both methods have been validated according to ICH requirements. The use of iodometric titration method for DMT analysis is demonstrated with a couple of applications.

Chromatography, Gas↗
PubMed1995

The challenge of performing three heart transplantations in one day.

Heart transplantation procedures, which present a number of challenges not generally seen in perioperative nursing practice, provide important knowledge for perioperative nurses because they demonstrate the importance of organization, communication, collaboration, and resourcefulness among surgical team members. On Friday, Aug 13, 1993, the Virginia Heart Center at Fairfax Hospital, Falls Church, implanted donor hearts in three adult recipients in a single day. The day was even more challenging because of elective coronary artery bypass graft procedures performed on three other patients. Successful response to the demands of Aug 13 was facilitated by the presence of skilled, versatile, cardiovascular OR staff members.

Adult↗
PubMed1995

Competency-based orientation for perioperative cardiovascular nurses.

Nurses working in cardiovascular surgery must be responsible and highly competent to meet the demands of their profession. Hospitals that hire nurses for cardiovascular surgery also must assume responsibility for the competency of nurses hired. The Virginia Heart Center at Fairfax Hospital, Falls Church, uses a competency-based orientation plan to train newly hired cardiovascular surgery nurses in providing quality care. Competency-based orientation is an effective approach to incorporating new members of the team into the work environment. The benefits of this appraoch include the development of teamwork and esprit de corps, skill and knowledge enhancement, and possible increased staff retention.

Cardiac Care Facilities↗