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Biomedical subjects

M Hussein

Publications and source records attributed to M Hussein.

10 recordsLinked to original sources
PubMed1992

The effect of ammonia on the respiratory nasal mucosa of mice. A histological and histochemical study.

The effects of prolonged exposure to ammonia vapour on the histological pattern and enzymatic activity of the respiratory nasal mucosa of 75 adult male mice were investigated and compared with a control group. In the exposed animals, the nasal epithelial cells showed patches of squamous metaplasia, dysplasia, and even malignant changes in the nose of 2 animals. As regards the histochemical changes, the apical border of epithelial cells showed increased succinic dehydrogenase activity denoting increased energy production. The acid phosphatase activity was also higher, and this seemed to be a constant feature in metaplastic and neoplastic transformation. The alkaline phosphatase activity was detected only in the basal parts of epithelial and goblet cells, which was attributed to an increased activity of basal cells to form a thicker basement membrane. The periodic acid Schiff's reaction was weak in the cilia due to their partial degeneration. Prolonged exposure to ammonia interfered with the normal physiological mucociliary action resulting in accumulation of particulate matter initiating or promoting a neoplastic process.

Acid Phosphatase↗
PubMed1992

A study on delayed hypersensitivity to rotavirus in infancy and childhood.

The T-cell responsiveness to rotavirus antigen and phytohaemagglutinin (PHA) together with T-cell total and subsets quantitation was carried out in 50 non-diarrhoeal and six rotavirus diarrhoeal subjects. All individuals in the non-diarrhoeal group responded well to PHA and had normal values for T-cell subsets. The number of positive responders to the rotavirus antigen increased gradually from 0% in the newborns to 92% in older children. The increasing risk of exposure to rotavirus infection is thought to be a chief cause of this age-related variation. All the rotavirus diarrhoeal patients responded well to the rotavirus antigen, indicating a potent test system. The T-cell responses to PHA and the T-cell subsets were significantly low. This could be due to temporary T-cell suppression that may accompany viral infection. Our results are discussed in the context of previous studies.

Antigens, Viral↗
PubMed1992

Vasculitis with eosinophilia and digital gangrene in a patient with acquired immunodeficiency syndrome.

Fewer than 40 cases of vasculitis have been described in the setting of human immunodeficiency virus infection. We describe a patient with the acquired immunodeficiency syndrome (AIDS), a heavy smoker, who developed a syndrome of constitutional symptoms, eosinophilia and digital gangrene. Vasculitis of the digital arteries was documented by angiography. He responded to high dose corticosteroid therapy with arrest of the ischemic process. After steroids were discontinued, he suffered a relapse of the vasculitis documented by skin biopsy. In patients with AIDS with this serious, potentially steroid responsive condition, steroid therapy should be considered in spite of the preexisting immunodeficiency state.

Acquired Immunodeficiency Syndrome↗
PubMed1991

Study on the pathogenicity of some Nocardia spp isolated from tap water of Ismailia City, Egypt.

All actinomycetes isolated from canal water, Ismailia water plant and tap water were identified into 5 genera. All Nocardia isolates were identified into 3 species. Two of which, Nocardia transvalensis and Nocardia otitidus-caviarus were recorded in tap water. These species are pathogenic for human kind and animals. The pathogenicity of these isolates was tested on Swiss Albino mice. Symptomatic changes and death of mice inoculated with Nocardia suspension were recorded. The main symptoms were erythema, enduration and inflammation together with abcesses and an increase in the size of the spleen (spleenomegally). It is concluded from these experiments that: i) All Nocardia species isolated from tap water are pathogenic, at least for mice, ii) these isolates could present health hazards to human kind and needs an urgent investigation.

Animals↗
PubMed1990

Estimating the cost of the most prevalent diseases of the retired beneficiaries of health insurance organizations in Alexandria.

A retrospective study was carried out in Alexandria Health Insurance Organization Polyclinics and pharmacies to determine the prevalence of diseases among the retired beneficiaries and their utilization of health insurance services, and to estimate the annual expenses by disease with comparison of the retired contributions and expenses. Arthritis (49.3%) and respiratory tract diseases (43.4%) were the for most prevalent disease groups. Ischaemic heart diseases ranked the first in term of total expenses. The outpatient medicaments constituted the largest burden of expenses and the expenditures were six to ten folds that of the retired contributions.

Aged↗
PubMed1979

Dinitrochlorobenzene sensitization in children with bronchial asthma.

Twenty-one patients with bronchial asthma were tested by dinitrochlorobenzene. Eleven did not react (52%). Five of the patients had been previously BCG vaccinated but did not react to PPD. The results indicated that some impairment of cell-mediated immunity in asthmatics exists. The correlation between this finding and pathogenesis of asthma is discussed.

Adolescent↗