PubMed Health⌕ Search

Biomedical subjects

M I Balabolkin

Publications and source records attributed to M I Balabolkin.

At least 19 recordsLinked to original sources
PubMed1992

[T-cell immunity and immunomodulators in the comprehensive treatment of diffuse toxic goiter].

Age-specific and related to DTG severity lowering of T-lymphocyte count, active and autologous T-lymphocyte number, thymic serum activity were found in 83 DTG patients. These shifts made justified the use of immunomodulator tactivin in 32 DTG patients. The drug was administered in daily subcutaneous doses (1 ml of 0.01% solution) for 5 days. As a result, the T-cell immunity returned to normal values. The highest response occurred in young subjects with moderate hyperthyroidism. Because a single tactivin course failed to bring up a persistent effect, repeat courses are needed to achieve good clinical and immunologic responses.

Adjuvants, Immunologic↗
PubMed1992

[The insulin-secreting and proliferative activity of established islet cells in the presence of sulfonylurea].

Exponentially growing rat islet cells (RINr) and hamster islet cells (HIT T-15) were incubated in presence of tolbutamide (10-1000 microM), gliclazide (0.1-10 microM) or glibenclamide (0.01-10 microM) for 15 hrs. Accumulation of insulin in culture medium was estimated by RIA. Effects of sulfonylureas (SU) on cell proliferation were assessed by 3H-thymidine (3H-T) incorporation into cellular DNA. All of SUs used stimulated insulin production in RIN and HIT cell cultures (with an exception of tolbutamide, which markedly suppressed insulin secretion in HIT cells at 1000 microM). 3H-T incorporation into RIN cells was elevated only in presence of gliclazide (10 microM), whereas tolbutamide at 1000 M significantly inhibited RIN cell proliferation. Gliclazide (0.1 microM) and glibenclamide (0.01-10 microM) enhanced 3H-T incorporation into HIT cells. Further detailed investigations of mechanisms of SU effects on islet cell reproduction will be of use for designing optimal strategy of hypoglycemizing therapy of diabetes mellitus.

Animals↗
PubMed1992

[Osteocalcin in diffuse toxic goiter].

Bone metabolism was investigated in toxic goiter. The authors obtained evidence on high levels of osteocalcin which marks bone formation. The time of the thyroid function recovery during thyrostatic therapy and indices of phosphorus-calcium metabolism disagree indicating delayed normalization of the bone tissue metabolism. There is a correlation between the thyroid function, osteocalcin and oxyproline that indirectly confirms the action of thyroid hormones on the bone matrix; between osteocalcin levels and other indices of bone metabolism (serum alkaline phosphatase activity and oxyproline excretion).

Adult↗
PubMed1991

[Effects of physical exercise on the parameters of carbohydrate metabolism in patients with type 2 diabetes mellitus during rehabilitative treatment].

The evidence obtained by the authors supports literature data on a beneficial effect of muscular exercise on carbohydrate metabolism in diabetics. It is thought necessary to control sharp fluctuations of glycemia. Provided these are mild and associated with lowered insulinemia, patients with non-insulin-dependent diabetes mellitus could be recommended to continue training.

Adult↗
PubMed1991

[The effect of diabeton and metformin on the free-radical oxidation processes and the structural characteristics of the phospholipid composition of the erythrocyte membranes in non-insulin-dependent diabetes mellitus].

Newly detected noninsulin--dependent diabetes mellitus is shown to have changes in phospholipid structure of erythrocytic membranes: a fall in total phospholipids, sphingomyelin, phosphatidylcholine, phosphatidic acid, a trend to increasing lysophosphatidylcholine. The shifts go in parallel with lipid peroxidation activation. Carbohydrate metabolism compensation is not enough to eradicate the shifts. The process is also dependent on the properties of a sugar-reducing drug. Diabeton is recommended as beneficial in this respect, while metformin is efficient in combinations.

Diabetes Mellitus, Type 2↗
PubMed1990

[The hypophyseal-adrenal system in chronic alcoholism].

Examinations of 115 patients with chronic alcoholism have revealed significantly reduced aldosterone concentrations in all of them. Hydrocortisone concentration had a tendency to reduction. Blood serum ACTH level in chronic alcoholics depended on the stage of the disease.

Adrenal Glands↗
PubMed1990

[Primary hyperparathyroidism].

Current views on etiology, pathomorphology and pathophysiology of primary hyperparathyroidism are briefly outlined. In the last two decades the incidence of the disease has been on the increase. Clinical and diagnostic aspects, differential diagnosis of various pathogenetic forms of hypercalcemia are discussed. Basic problems of surgical treatment are considered. A scheme of hypercalcemia crisis management has been developed.

Adenoma↗
PubMed1990

[The physical work capacity of diabetics during rehabilitative treatment].

Work fitness was assessed in 120 patients with diabetes mellitus (DM) of varying gravity according to which all the patients were distributed into 3 groups of DM. Work fitness was discovered to be lowered, correlating with the disease gravity. Overweight was noted to influence its lowering. During rehabilitation treatment including dietetic management, the treatment with sugar-reducing drugs, physical rehabilitation, work therapy and physiotherapy, work fitness and hemodynamics improved. The rise of work fitness due to rehabilitation treatment was associated with its more effective maintenance. Compensation of DM is a necessary prerequisite for work fitness increase.

Blood Glucose↗
PubMed1990

[Pharmacodynamic metoclopramide (cerucal) test in differential diagnosis of hypoprolactinemic hypogonadism syndrome in women].

Roentgenology revealed pituitary macroadenoma in 13 of 67 women with hyperprolactinemia. Craniographic structural abnormalities of the sella turcica suggested pituitary microadenoma in 20 women. Metoclopramide (cerucal) test was performed in the patients and a control group of 9 healthy women. Blood concentrations of prolactin (prolactin, somatotropic thyroid-stimulating hormone) were determined with a radioimmune assay. Significant disorders of the hypothalamo-pituitary control were detected, presenting as depressed and delayed prolactin and TSH response in this assay. The neuroendocrine disorders were most severe in patients with macroprolactinoma who showed a refractory prolactin secretory response to dopaminergic metoclopramide inhibition. The patients with microprolactinomas had a low prolactin response (increments less than 300-400%) and delayed TSH response. The metoclopramide test is recommended for differential diagnosis of hyperprolactinemic syndrome.

Adult↗
PubMed1990

[Hyperprolactinemia syndrome in men].

A total of 122 male subjects suffering from secretory infertility were examined. In 25 of them (20 percent) blood prolactin levels were above the norm. Measurements of basal prolactin levels and of its secretion in metoclopramide test helped distinguish two types of hyperprolactinemia syndrome, differing in the pattern of spermatogenesis disorders. Possible pathogenesis of individual types of hyperprolactinemia in men is discussed. Therapy with dopamine agonists (lisenyl, parlodel) was found most effective in Type I hyperprolactinemia syndrome, associated with essential prolactin hypersecretion and oligospermia.

Adult↗