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Biomedical subjects

M I Blake

Publications and source records attributed to M I Blake.

At least 37 records · Page 2Linked to original sources

Differentiating nonaqueous titration of aspirin, acetaminophen, and salicylamide mixtures.

Mixtures containing aspirin, acetaminophen, and salicylamide were assayed potentiometrically by nonaqueous titration. The difference in pKa values for these weak acids was sufficient to permit successful differentiation. The titrant was tetrabutylammonium hydroxide, and the titration solvent was dimethylformamide. The procedure was applied to commercial dosage forms.

Acetaminophen↗

Deviation of dielectric constant from ideality for certain binary solvent systems.

An equation was derived which relates the dielectric constant of mixtures of a binary solvent system to the mole fraction of the polar and nonpolar components of the system. The coefficients of the formula are readily calculated from the dielectric constant and the molar volume of the pure components of the binary solvent system. These calculated values are employed in graphical representations of the theoretical relationship of the dielectric constant of the binary solvent system and the mole fraction of the polar component of the solvent system. Experimental measurements are employed to demonstrate deviations from ideality.

Acetone↗