Ketamine-HCI as a suitable anesthetic for endocrine, metabolic, and cardiovascular studies in Macaca fascicularis monkeys.
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Animals↗
Biomedical subjects
M I Castro
Publications and source records attributed to M I Castro.
Alcohol and fetal endocrine function.
Maternal alcohol abuse during pregnancy represents a significant risk to normal perinatal growth and development. The mechanisms involved in the deleterious effects of alcohol on the fetus are unknown but may involve perturbations in fetal endocrine function. Consequently, we have begun to examine the effects of alcohol exposure on thyroid and adrenal cortical function in the chronically cannulated ovine fetus. Our results indicate alcohol exposure in utero affects both the pituitary-thyroid and the adrenal cortical system in the fetus. Fetal pituitary-thyroid function appears depressed and fetal adrenal cortical function increased by alcohol.
Animals↗
[Evaluation of the effectiveness of a program of detection of asymptomatic Chlamydia trachomatis infection in women].
BACKGROUND: Chlamydia Trachomatis is at present the most prevalent pathogenic agent among the causes of sexually transmitted diseases in developed countries, and has reached epidemic proportions in some of them. These infections can give rise to a considerable number of complications, many with very serious consequences. Given that, in addition, a great number of cases are asymptomatic, a general consensus exists about the convenience of carrying out screening programmes. The aim of this study is to accomplish the first stage of the screening programme of asymptomatic infection by C. trachomatis in women who seek help at a family planning centre. METHODS: A descriptive study to determine the prevalence each year of the period studied, an analysis of its temporal tendency and the assessment of the programme effectiveness in terms of a proportional reduction in prevalence. A total number of 6.746 women were included, who attended the family planning centre for a regular checkup or contraceptive advice between January 1991 and December 1993. RESULTS: The programme showed a global effectiveness rate of 80%, with a reduction in prevalence from 5.1% in 1990 to 1.0% in 1993. A significant fall was observed in all the categories analyzed, except for women using prophylactics and those with higher education. CONCLUSIONS: The programme achieves its objectives very effectively. Nevertheless, it would be advisable to evaluate its efficiency together with a cost-analysis, since by reducing prevalence, the positive estimated value of the test considerably decreases, which raises the cost of a single case detection.
Adolescent↗