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Biomedical subjects

M I Dvorkin

Publications and source records attributed to M I Dvorkin.

9 recordsLinked to original sources
PubMed1989

[The thrombocytolysis phenomenon in patients with myocardial infarct].

The studies have revealed that the platelets of myocardial infarction patients are lysed when in vitro exposed to the necrotic myocardial antigen or to actomyosin proteins within this antigen, this lysis correlating with the disease clinical course. The reaction is specific. High antigen platelet lysis (greater than 14%) in the first day of myocardial infarction frequently aggravates the course of the disease. The prognosis based on this test helps single out the patients with an aggravated condition among those with myocardial infarction.

Actins↗
PubMed1985

[Cytotoxic effect of the lymphocytes in ischemic heart disease].

Coronary patients were shown to have a pool of sensitized killer T cells that produce a cytotoxic effect on target cells loaded with infarcted and intact myocardial antigens and on actomyosin proteins, and evidence of delayed hypersensitivity developing in association with coronary disease. Two kinds of immune shifts were identified with respect to the time of onset of this effect in acute myocardial infarction: in the first case, the appropriate level was exceeded within 2-3 weeks of the disease, and in the second case, within the first days in hospital. The disease tended to take a more severe course in patients with the second type of immune response.

Actomyosin↗
PubMed1984

[Immunologic shifts at different stages of coronary disease].

Immunologic shifts and indices of nonspecific reactivity were examined in 261 coronary heart disease patients (40 patients with angina pectoris, 137 with acute myocardial infarction and 124 patients with postinfarctional cardiosclerosis). Cell-mediated and humoral immune responses to the infarctional antigen affecting the prognosis and the clinical course of the disease were determined in the acute, subacute and long-term periods of coronary pathology. Autoimmune reactions to the myocardial innate antigen can be detected at all stages of coronary heart disease. Myocardial infarction is also characterized by dysfunctions of individual links of nonspecific reactivity.

Angina Pectoris↗
PubMed1984

Immunological changes in the organism of patients with myocardial infarction.

The study included 261 patients with myocardial infarction in whom heart antibody titre, the index of leucocyte migration and the indicator of their agglomeration with antigen from the infarction and perinfarction region were investigated. Two variants of immunological changes occurring in acute coronary disease were identified--one characteristic of a favourable course of the disease, the second characteristic of a complicated course in the acute and late periods. In patients with prior myocardial infarction, residual sensibilization is present both after discharge from the hospital and 1 to 3 years later.

Adult↗