Lipid absorption in newborn rat intestine.
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Biomedical subjects
M I Ferlatte
Publications and source records attributed to M I Ferlatte.
Effect of prenatal protein deprivation on fetal and neonatal thyroid morphology in the rat.
Morphogenesis of the thyroid was compared in young of control and protein-deprived rats from day 17 of gestation through the first postpartum day. Examination of histological sections revealed a significant delay in follicle formation and a reduction in gland area, follicle number, colloid space and cell size in the thyroid tissue of fetal and neonatal pups of protein-deprived dams.
Animals↗
Thyroid function in prenatally protein-deprived rats.
Thyroid function was examined in fetal and newborn young of dams fed diets containing 24% or 4% casein as the sole source of protein. Radioactive iodine uptake, as examined autoradiographically and by gamma counting, was significantly reduced in glands of progeny of deficient rats. Following injections of thyrotropin or thyrotropin releasing hormone, thyroid cells of newborn young of protein-deprived rats contained fewer colloid droplets than those of control pups. Circulating levels of triiodothyronine and thyroxine were significantly reduced in the plasma of newborn young of protein-deprived females as compared with controls.
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Early postnatal development of the intestine in progeny of protein-deprived rats.
Development of the small intestine was studied in newborn, and 4-, 8-, and 12-day-old young of rats fed diets, during gestation, containing 24 or 4% casein as the source of protein. Newborn prenatally protein-deprived rats had shorter, narrower intestines, reduced numbers of villi per unit length, shorter villi, and reduced numbers of absorptive cells and crypt cells. These differences had disappeared by the age of 12 days in adequately fed pups that had survived to that age.
Animals↗
The effects of prenatal protein deprivation on thyrotroph development.
Maternal dietary protein restriction produced by feeding a diet containing 4% casein throughout gestation adversely affects body size and retards development of various organs in the progeny. For the most part, alterations are present in structural or functional entities which evolve during the last trimester of gestation. Fetal thyroid follicle formation and iodine concentrating capacity, which increase rapidly between the 17th gestational day and birth in pups of dams fed the control (24% casein) ration, are retarded in age-matched pups of protein-deficient females. The first immunoreactive thyrotrophs appear in the fetal pituitary on day 17 in both control and prenatally protein-deprived (PPD) young. The total number of thyrotrophs per pituitary was unaffected by maternal protein deficiency, except on day 21 when there were significantly more thyrotrophs per pituitary in fetal control rats. Although pituitary volume was significantly reduced in 18-, 19- and 21-day old fetal PPD rats, as compared with controls, pituitary volume:body weight ratios differed between young in the two dietary groups only on day 21, when the ratio was significantly higher in PPD as compared to control young. Maternal protein deprivation does not affect the morphological maturation of the thyrotrophs of the anterior pituitary of the fetal rat.
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