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Biomedical subjects

M I Greenberg

Publications and source records attributed to M I Greenberg.

7 recordsLinked to original sources
PubMed1979

Blood levels following intravenous and endotracheal epinephrine administration.

The blood levels of epinephrine and its metabolites which were obtained when the drug was given by both the intravenous (IV) and endotracheal (ET) routes were compared. Anesthetized dogs were subjected to radioactive epinephrine in doses of 0.005, 0.03, 0.06, and 0.09 mg/kg administered both intravenously and endotracheally. Blood levels were obtained at 0.25, 0.75, 1.5, 3, 5, 10 and 30 minutes following injection and analyzed by thin layer chromatography. The maximum measured concentration following IV injection was observed at 15 seconds. Epinephrine was rapidly metabolized with 20% of the original concentration detected at 5 minutes following IV injection. When the drug was given by the ET route, the maximum measured concentration was similarly observed at 15 seconds. Following ET installation, initial blood concentrations are sustained over a much longer period of time and 80% of the initial concentration was detected at 5 minutes. Maximum concentrations are approximately one-tenth of those achieved with an equal IV dosage. It is concluded that endotracheally and intravenously administered epinephrine rapidly reach maximum blood levels although there are differences in kinetics between the two routes.

Animals↗
PubMed1979

Endotracheal epinephrine in a canine anaphylactic shock model.

This study was undertaken to determine if epinephrine administered endotracheally is as effective in treating anaphylactic shock as is intravenously administered epinephrine. An animal model of anaphylactic shock was produced in anesthetized dogs by the intravenous administration of histamine phosphate. Both the endotracheal and intravenous routes of epinephrine administration resulted in efficient and effective reversal of histamine-induced hypotension. At the doses employed, the intravenous administration of epinephrine resulted in the production of significantly (p less than 0.05) greater numbers of ventricular cardiac arrhythmias than did the endotracheal route of administration.

Anaphylaxis↗
PubMed1979

Endotracheal epinephrine in cardiorespiratory collapse.

The endotracheal route for the administration of epinephrine has been studied extensively in dogs. There has been little in the medical literature to document the successful use of this technique in humans. The successful use of endotracheally administered epinephrine in two patients with cardiorespiratory collapse is reported. Specific points concerning endotracheal drugs are discussed and a set of guidelines for clinical use is offered.

Epinephrine↗
PubMed1978

Falls from heights.

Falls from heights are most commonly due to accidents in children and suicide, accident, and crime-related incidents in adults. Two types of injury result from falls from heights: injury resulting from direct impact and deceleration-type injury. The injuries resulting from direct impact are mostly fractures. The body position at impact is crucial. The deceleration forces immediately post-impact result primarily in visceral and internal injury, including cranial injury. There is a lack of correlation between os calcis fractures and vertebral fractures. Spinal cord injury is infrequent. Survival figures are higher than usually assumed.

Accidental Falls↗
PubMed1978

High-pressure injection injury with river water.

A case of high pressure injection and laceration of the calf with river water is reported, the first such case appearing in the literature. As with high pressure injection of grease, paint, paint thinner, mineral spirits, diesel oil, gasoline, and turpentine, this injury is a surgical emergency. All patients must be admitted for surgical debridement, irrigation, parenteral antibiotics, and observation. River water, contaminated by sewage and industrial wastes, has great irritative and infective potential.

Adult↗