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M I Grosso

Publications and source records attributed to M I Grosso.

5 recordsLinked to original sources
PubMed1990

In vivo interleukin 2-induced activation of lymphokine-activated killer cells and tumor cytotoxic T-cells in cervical lymph nodes of patients with head and neck tumors.

To study whether regional injection of recombinant interleukin 2 (rIL-2) can induce an in vivo lymphocyte activation in cervical lymph nodes (LNs) of patients with head and neck carcinoma, 12 patients, candidates for prophylactic dissection, were treated for 7-10 days prior to surgery with rIL-2, 10(5) units/day, injected in the perimastoid region. A marked induction of cytotoxic activity against allogeneic (K562 and Daudi lines) and autologous target cells (fresh spindle cell carcinomas of the tongue) was observed in lymphocytes obtained from jugular, spinal, and, to a lesser extent, submandibular LNs of all treated patients. An increase of cytotoxicity was also present in LNs contralateral to the rIL-2 injection side. On the other hand, only a borderline increase in spontaneous proliferation was detected. Moreover, in the two cases tested, a marked and apparently autologous tumor (Auto-Tu)-specific lysis was found in CD5+ lymphocytes obtained from LNs, whereas lymphokine-activated killer activity was mainly exerted by CD16+ natural killer cells. T-lymphocytes, when cultured with irradiated Auto-Tu cells and low doses of rIL-2, showed an increased Auto-Tu lysis, while cytotoxicity against allogeneic tumor cells (including K562) was not observed. These data indicate that regional injection of rIL-2 can activate lymphokine-activated killer cells from LN lymphocytes but also induce and/or expand a T-cell population expressing a restricted Auto-Tu cytotoxicity.

Aged↗
PubMed1985

[Technic of multiple procurement from donor cadavers (observations on 19 cases)].

Several procedures for multiple cadaveric organ procurement have been developed for the recent growth of transplantation of extrarenal organs. These techniques permit removal of the kidneys, liver, pancreas and heart from the same donor without jeopardy to the kidneys above all. At the Department of Surgery - Section Transplantation of the University of Genoa in 1983 and 1984 19 multiple organ harvesting have been carried out. The kidneys were transplanted at our Center or at other Nit Center. Two patients received segmental pancreatic allograft. Two livers were sent to other Italian and European Centers and successfully transplanted.

Adolescent↗
PubMedDate not supplied

[Giant juvenile angiofibroma: which surgical approach?].

The juvenile angiofibroma is an uncommon, highly vascular, locally invasive, non encapsulated tumor. In spite of its benignity the above mentioned peculiarities make the therapy very hard. The estrogenic hormones and the radiotherapy were used for years but there were many iatrogenic after-effects. The preferred treatment is surgical. Many surgical approaches were used. Everyone has advantages and disadvantages. The choice may be free for tumors of small or medium size. When the tumor is very large, stage III A or more, a single approach isn't enough. A double approach is mandatory; one must be an infratemporal approach (pre o postauricular). We present a case of juvenile angiofibroma stage III B which is a good pattern of the above mentioned statements.

Adolescent↗