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Biomedical subjects

M I Gubarev

Publications and source records attributed to M I Gubarev.

4 recordsLinked to original sources
PubMed1989

[The protective effect of preparations made from plant seedlings in experimental Pseudomonas aeruginosa infection].

The influence of preparations obtained from oat and wheat seedlings (immunostimulating factors IF-1 and IF-2, respectively) on the natural resistance of mice to P. aeruginosa infection was studied. IF-1 and IF-2 were introduced intraperitoneally in a single injection in doses of 100 micrograms and 1000 micrograms per mouse 2 and 7 days prior to the inoculation of P. aeruginosa strain 8 in doses of 1 and 10 LD50. The presence of substances capable of stimulating the immunobiological reserves of the body in actively growing plants (seedlings) was shown.

Adjuvants, Immunologic↗
PubMed1986

[Bone marrow suppressor cells of patients with viral and alcoholic liver cirrhoses].

A study was made of bone marrow suppressor cells potencies in 12 viral and alcoholic liver cirrhosis patients and 6 healthy persons using a method of the registration of bone marrow suppressor cells activity in the inhibition of xenogenic target cells proliferation. The activity of bone marrow suppressor cell in viral and alcoholic liver cirrhosis was significantly lowered as compared to that of the healthy donors. Besides, the spontaneous bone marrow cells proliferation level both in viral and alcoholic liver cirrhosis exceeded essentially that of the healthy donors. It might be due either to the reduced number or decreased function bone marrow suppressor cells in liver cirrhosis. These patients' peripheral blood lymphocytes under in vitro conditions as well as the healthy donors' lymphocytes did not produce any suppressive effect.

Adult↗
PubMed1985

[Normal human bone marrow suppressor cells and in liver cirrhosis].

Suppressor properties of bone marrow cells were studied in healthy donors and patients with hepatocirrhosis using the technique registrating the activity of bone marrow B-suppressors by the inhibition of xenogenic target cell proliferation. The activity of bone marrow suppressor cells in patients with various types of hepatocirrhosis was reduced as compared to healthy subjects. In addition, the in vitro spontaneous proliferation level of bone marrow cells in hepatocirrhosis was considerably higher than that of healthy donors. This fact can be possibly attributed to the decline in the number of bone marrow B-suppressors or inhibition of their functional activity in hepatocirrhosis. Peripheral blood lymphocytes of these patients, like the lymphocytes of healthy donors, showed practically no suppressive effect in vitro.

Animals↗