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Biomedical subjects

M I Gurevich

Publications and source records attributed to M I Gurevich.

At least 19 recordsLinked to original sources
PubMed1989

[The age-related characteristics of the effect of vasopressin on the vascular smooth muscles of the human brain].

Vasopressin was shown to cause a concentration-dependent relaxation of human basilar [correction of bacillary] artery's smooth muscles. In old age, the reactivity of these muscles in decreased and tachyphylaxis to vasopressin disappeared. This seems to be connected with a decrease in the quantity of smooth muscle's V2-inhibitory receptors. Protein kinase C activation does not affect molecular mechanisms of vasopressin action on human basilar [correction of bacillary] artery's smooth muscles. The data obtained suggest vasopressin participation in regulation of human cerebral blood flow and a limitation of adaptive properties of brain vessels' smooth muscles in old age. These factors, apparently, play a role in development of the brain circulation pathology in old men.

Adult↗
PubMed1988

[Role of vasopressin in the development of arterial hypertension and the search for ways to correct it].

The sensitivity of the vessel smooth muscles to vasopressin and their contractile responses were obviously increased in hypertensive rats, whereas the vasopressin inhibitory effect and tachyphylaxis were decreased. These changes seem to be connected with the prevalence of V1-activating over V2-inhibitory vasopressin receptors in hypertensive rats' vessel smooth muscles. Administration of lithium oxybutyrate for 4 weeks normalized central hemodynamics and decreased the sensitivity to vasopressin. The findings suggest a possible role of the inositol pathway in transmission of hormonal signal (vasopressin) to hypertensive rats' vessel smooth muscles as well as participation of vasopressin in pathogenesis of arterial hypertension and the possibility of using lithium oxybutyrate for its correction.

Animals↗
PubMed1984

[Effect of isopropylnoradrenaline included in liposomes on cardiac hemodynamics during the adrenoreceptor blockade].

Isopropylnoradrenaline (INA) included in liposomes caused positive inotropic and system depression effects in cats. Duration of the reaction increased by 3.5 times compared with the response to a free form of beta-adrenomimetic. It was shown that the liposome beta-adrenomimetic induced a cardiostimulating effect under blockade of adrenergic receptors and increased the arterial blood pressure in this condition. Administration of INA after liposomes increased the arterial blood pressure as well. The data obtained suggest that the specific character of adrenergic receptors can be altered with exogenous phospholipids.

Animals↗
PubMed1983

[Age characteristics of the effect of insulin on smooth muscle cells of the femoral artery].

A study was made of the effects of insulin on smooth muscle cells (SMC) of the femoral artery of rats aged 6-8 and 24-26 months. Insulin hyperpolarized the SMC membrane and diminished the tone of smooth muscles of the vessels. These effects were dependent on the hormone concentration and perfusate temperature. In old animals, the sensitivity of smooth muscles of the vessels to insulin and the response to higher concentrations were reduced. It is believed that the changes described may play a definite role in the mechanisms by which the vascular tone is controlled.

Aging↗
PubMed1983

[Cardiostimulating action of liposome-incorporated noradrenaline during adrenergic-receptor block].

Norepinephrine (NE) contained in liposomes increased myocardial contractility and raised the blood pressure with no bradycardia or arrhythmia. NE exerted this cardiostimulating effect in condition of complete adrenoreceptor blockade. Separate infusion of NE and liposomes restored the sensitivity of the adrenergic structures in adrenergic blockade. Modified effect of liposome-entrapped NE depends on liposome effect upon the cell membrane and on concentration of NE in the blood.

Animals↗
PubMed1982

[Intracentral relationships of brain structures participating in blood circulation regulation].

Hemodynamic responses to stimulation of different hypothalamic sites, to simultaneous stimulation of the sinus nerve and a hypothalamic site as well as monosynaptic hypothalamic projections to brain stem structures and spinal cord as studied in anesthetized vagotomized cats revealed that hypothalamic influences to efferent link of cardiovascular control involved different efferent projections with activation of various groups of brain structures. A scheme showing intracentral monosynaptic projections participating in cardiovascular control was drawn.

Animals↗
PubMed1981

[Effect of increasing the osmolarity of the extracellular medium on conduction, contractile responses and ultrastructure of vascular muscle].

Increased osmolarity of extracellular milieu suppresses spontaneous contractions of the v. porta smooth muscles first due to disturbance of excitation conduction among the cells necessary for rhythmic contractions of the muscles. Further suppression is due to decrease in the rhythmic electrical activity of the spontaneously active pace-maker smooth muscle cells (SMC). Increased osmolarity alters the SMC reactive ability: their responses to noradrenaline and acetylcholine become less obvious. Increased osmolarity induces lesion of the intercellular contacts, wrinkling of the cells and disorder in the structure of cellular membranes.

Acetylcholine↗
PubMed1980

[Age and features of the functional properties of vascular smooth muscle cells].

Studies on the electric and contractile properties of smooth muscle cells (SMC) of the portal vein of rats aged 6 to 8 months and 26 to 28 months showed that the number of spontaneously active cells, the membrane potential of SMC and action potential amplitude change with age. The force and duration of spontaneous phasic contractions of the strips of test vessels increased. The old animals had a reduction in the maximum rate of contraction and relaxation. These changes play a definite role in the mechanism of vascular tone shifts and in their function during ontogenesis.

Action Potentials↗
PubMed1978

[Relationships between central and local mechanisms regulating hemodynamics].

The quantitative analysis of hemodynamic shifts during cardiovascular responses to stimulation of central neural structures, and recording of electric activity from the sympathetic fibers elucidate different links in the complex mechanism of the hemodynamic control. Monosynaptic connections of the sino-aortic zone with some structures of the bulbar level seem to contain relevant information on the blood pressure and the gas content. Differentiated modulated influences project from the cerebellum to the bulbar level, and complex interrelationships of local metabolic and central reflex mechanisms occur during acute hypoxic hypoxia.

Animals↗