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Biomedical subjects

M I Korzekwa

Publications and source records attributed to M I Korzekwa.

2 recordsLinked to original sources
PubMed1997

Premenstrual syndromes.

Premenstrual syndrome research has made a great deal of progress since 1983 when the criteria for the diagnosis were clearly defined. Confirming the diagnosis prospectively and ruling out other disorders was a major methodologic advance. The DSM-IV criteria for PMDD now help us identify and classify women who have severe psychologic symptoms during the premenstruum. Although we do not have a definitive cause for PMDD, the consensus is that it is the end result of a complex series of events mediated partly by the serotonin system and triggered by ovulation. Women who meet criteria for PMS, do not meet the criteria for PMDD, and do not have a concurrent disorder should be treated conservatively. Women who meet criteria for PMDD can be treated successfully with low-dose clomipramine, SSRIs, or GnRH-as with "add back" estrogen and progestins.

Evidence-Based Medicine↗
PubMed1996

Late luteal phase dysphoric disorder and the thyroid axis revisited.

Late luteal phase dysphoric disorder (LLPDD), also known as premenstrual dysphoria, has been etiologically linked to both depression and thyroid disease. We examined baseline and TRH-stimulated thyroid function in 45 otherwise healthy women with prospectively confirmed LLPDD during the follicular and luteal phases of their menstrual cycles. The means of all thyroid variables were normal. Three (6.8%) subjects had elevated baseline TSH (mild hypothyroidism), and 6 (13.3%) had an exaggerated TSH response (delta max TSH) to TRH (subclinical hypothyroidism). A blunted delta max TSH (< 5 mU/L) was found in only 4.4% of the subjects. History of a past major psychiatric diagnosis (mostly depression) or a current personality disorder correlated with a lower delta max TSH. As baseline TSH, using the new ultrasensitive radioimmunometric assay, correlated strongly with delta max TSH, the utility of the TRH challenge is questioned. Our findings suggest that LLPDD is not related to depression on the basis of this marker and that hypothyroidism is not the cause of LLPDD.

Adolescent↗