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Biomedical subjects

M I Kulick

Publications and source records attributed to M I Kulick.

10 recordsLinked to original sources
PubMed1988

Topical minoxidil: its use in treatment of male pattern baldness.

This review outlines the findings associated with topical minoxidil use. Approximately one-third of the treated patients will obtain terminal hair growth using a 2 to 3% solution twice a day. Patients should receive treatment for a minimum of six months to evaluate the drug's efficacy. Factors associated with patients who obtained new hair growth include: a thinning versus absolute baldness, treatment initiated at a relatively younger age, and hair growth noted within three months. Following a positive growth response, there may be a reduction in new hair growth gained with minoxidil use for more than one year. Stopping the medication is associated with an exacerbation of hair loss. Currently, patients with hypertension, cardiovascular disease, or any serious systemic illness should be excluded from therapy. Patients should be monitored every four to six months, or sooner with any complaints. Initial evaluation should include monitoring of the blood pressure, pulse, electrocardiogram and serum lipid determinations.

Administration, Topical↗
PubMed1986

Long-term analysis of patients having surgical treatment for carpal tunnel syndrome.

This retrospective study of 100 patients who had surgical treatment for their carpal tunnel syndrome was performed to determine what factors were associated with long-term success or failure. One hundred thirty hands were treated surgically with an average follow-up of 4 years (range, 2 to 6 years). All patients were given a course of conservative treatment that included steroid injection(s) and splinting until the patients were refractory to such therapy. Over 250 injections were given (117 wrists), with the average benefit time of 27 weeks (range 0 to 330). Most patients received two to three injections (maximum of nine). Variables associated with a failure to have long-term benefit after operation included weakness or atrophy of the abductor pollicis brevis muscle, presence of a predisposing condition, and failure to benefit from the initial steroid injection. Conversely, all 51 hands that had relief from median nerve paresthesia for more than 6 months by conservative therapy alone received long-term relief after surgery. Steroids were least effective in hands that had muscle involvement. Fifteen of the 40 hands with muscle involvement regained their muscle mass by the time of the final examination.

Adult↗
PubMed1986

Oral ibuprofen: evaluation of its effect on peritendinous adhesions and the breaking strength of a tenorrhaphy.

In a study of 21 primates, treatment with oral ibuprofen significantly reduced the force required for tendon gliding following flexor tendon injury in zone II. Tendons that were partially lacerated but not repaired required less force for tendon motion than those repaired. Ibuprofen also reduced the breaking strength of completely divided and repaired extensor tendons. The addition of a piece of chromic suture buried across the extensor tenorrhaphy site significantly increased the breaking strength of the repair in control and treated animals alike. These findings were observed at 4 and 6 weeks after tendon injury and repair. No adverse reactions to the medication were observed.

Administration, Oral↗
PubMed1986

A 30-year follow-up of wax injection for the prevention of androgenic alopecia.

In summary, we present a 30-year follow-up of injected wax for the prevention of male-pattern baldness. Removal was precipitated by the presence of a fibroxanthoma of the scalp. No other scalp lesions were found, nor were there any manifestations of an autoimmune disease. The injected wax failed to prevent androgenic alopecia and created a remodeling of the outer table of the cortex of the skull.

Alopecia↗
PubMed1985

Pseudotendon formation after flexor tendon injury.

The biologic reconstitution of a divided flexor tendon by scar tissue forming a "pseudotendon" is described in three cases. With close inspection, one is able to differentiate a pseudotendon from a normal tendon intraoperatively by its relatively light gray color and the lack of a glistening surface. A pseudotendon lacks the tensile strength of a normal tendon and should be replaced by tendon grafting or transfer if function is to be restored.

Adult↗
PubMed1985

Prospective study of side effects associated with the use of silver sulfadiazine in severely burned patients.

We report the results of a prospective study of 45 burn patients in whom serum and urine levels of cream constituents (sulfadiazine and propylene glycol) were determined and correlated with clinical parameters and the presence of an immune response to sulfadiazine. Propylene glycol, measured by gas chromatography, was found in the serum of 53% of study patients. Sulfa, determined by spectroscopy, was found in the serum of all patients, with values as high as 9.1 mg/dl within 24 hours of topical application. Ninety percent of tested patients had circulating sulfadiazine antibodies, predominantly IgG. Fourteen patients died, 11 of whom had interpretable renal biopsies. Five of these biopsies showed positive immunofluorescent linear or granular staining for IgG, IgM, IgA, or C'3; none of these 5 patients had clinical evidence for the nephrotic syndrome. The association between antisulfadiazine antibodies, circulating immune complexes, immunoglobulin disposition on glomerular basement membranes, and topical application of silver sulfadiazine provides evidence for sulfadiazine sensitization in patients with severe burns.

Administration, Topical↗
PubMed1984

Free perichondrial graft from the ear to the knee in rabbits.

Perichondrial grafts used in arthroplasties have been placed routinely with the cartilage-producing surface facing the joint space. Our study evaluates whether the orientation of the cartilage-producing surface of the perichondrial graft toward or away from the eburnated bone had any effect on the graft pattern 8 weeks after surgery. Fourteen rabbits were studied. The cartilage of both lower limb patellae was removed in all rabbits. The eburnated surfaces of 12 rabbits received perichondrial grafts from the ear, cartilage-producing side facing the joint space in one limb and cartilage-producing surface facing the bone in the other. Two rabbits that received no perichondrial grafts were also studied. After 8 weeks, the animals were killed and the patellar surfaces evaluated by gross and histologic studies. We observed that graft orientation made no difference in the histologic appearance or the thickness of the neocartilage formed.

Animals↗
PubMed1984

Injectable ibuprofen: preliminary evaluation of its ability to decrease peritendinous adhesions.

Peritendinous adhesions continue to limit the full return of hand function following flexor tendon injury and repair. Pilot studies in rabbits demonstrated the ability of ibuprofen (Motrin) to reduce intra-abdominal adhesions. In this study, ibuprofen injected at the site of flexor tendon repair significantly reduced the restrictive effects of peritendinous adhesions in primates.

Animals↗
PubMed1980

Hyperosmolality in the burn patient: analysis of an osmolal discrepancy.

In our study of 262 hospitalized flame burn patients, serum hyperosmolality, defined as having at least two reported osmolality values greater than 310 mOsm/kg, was observed in 15 patients (6%). From this group, nine patients were found to have an osmolal discrepancy (reported serum osmolality minus calculated serum osmolality). All patients in this group had a burn surface area greater than 35% TBS. The discrepancy between reported osmolality values of two patients from this group, determined by freezing point depression and vapor point analysis, suggested that a volatile substance was contributing to the osmolality. Further analysis by gas chromatography revealed propylene glycol as the agent accounting for most of the osmolal discrepancy. The only exposure to this polyalcohol was from the topical antibiotic cream (silver sulfadiazine) used in their treatment.

Adolescent↗