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Biomedical subjects

M I Martynova

Publications and source records attributed to M I Martynova.

At least 19 recordsLinked to original sources
PubMed1992

[Characteristics of immunobiological resistance of children with diabetes mellitus].

Immunoglobulins and nonspecific defence factors (complement, properdin, lysozyme) were studied over time in 194 children suffering from diabetes mellitus. In 145 children, diabetes mellitus was associated with chronic tonsillitis. Resistance in 49 children was examined depending on the phase of diabetes mellitus. The data obtained indicate that diabetes mellitus is marked by imbalance of nonspecific defence factors and humoral immunity. These changes are obviously related to the disease gravity, phasic nature of the process, diabetes mellitus standing, and the presence of concomitant diseases. No parallelism was established between the level of nonspecific defence factors and specific immunity activity.

Adolescent↗
PubMed1992

[Frequency of detection of hepatitis B markers in various chronic diseases in children].

Overall 995 children with different somatic chronic diseases were examined for viral hepatitis B markers demonstration using up-to-date highly sensitive methods (hemagglutination inhibition test, EIA). In the control group (children with acute intestinal infections), HBV-infection markers were discovered in 4.3%. Children with diabetes mellitus (13.1%), chronic renal diseases (18.9%), pulmonary diseases (32.8%), bronchial asthma (33.3%) and hemophilia (85.2%) are attributed to the group at greater risk for HBV infection. As a rule, the rate of HBV-infection markers demonstration in chronic somatic diseases was higher in considerable duration of the underlying illness. The overwhelming majority of the children examined had suffered subclinical forms of HBV-infection as shown by the disease history, whereupon they manifested antibodies against HBV antigens. HBs-antigenemia, that persisted for a long time (chronic HBV-infection) was demonstrable far less frequently. The authors provide evidence for the necessity of carrying out a broad-scale screening of HBV-infection markers in the indicated risk groups and vaccination against hepatitis B in children without HBsAG and without immunity to viral hepatitis B. The importance of measures aimed at preventing infections transmitted via blood is emphasized.

Biomarkers↗
PubMed1991

[Socio-demographic characteristics of the families of children with diabetes mellitus].

++Semi-closed interview was used to examine some social and demographic characteristics in 201 families having children of the school age suffering from diabetes mellitus (a random sample). Among sick children of Moscow highly aggravated heredity as regards diabetes mellitus was established (44.28%). In the first year of life, the majority of diabetes mellitus children had unsatisfactory living conditions, the family income per capita was low. Today 16.4% of the children continue having unsatisfactory living conditions; in the majority of the families (62.7%), the income per capita does not exceed 100 roubles. Among parents of diabetes mellitus children, the main group is made up of white collars, engaged primarily in intellectual activity and having a high educational level. The latter circumstance makes it possible to perfect the methods of the control over diabetes mellitus children in the family itself, which is to be coupled with systematic sanitary and instructive work on the part of the public health bodies.

Adolescent↗
PubMed1991

[The role of thromboxane A2 and prostacyclin in the pathogenesis of diabetes mellitus in children and adolescents].

The follow-up of children and adolescents (n-41) suffering from insulin-dependent diabetes mellitus has demonstrated that the increase of the thromboxane/prostacyclin ratio pointing to the derangement of microcirculatory regulation occurs during the decompensation phase of the disease and is a risk factor of the development of diabetic complications. The revealed disorders of arachidonic acid metabolism may be one of the causes of the tendency towards decrease of pulse arterial pressure in grave diabetes mellitus.

Adolescent↗
PubMed1991

[Study of unsaturated plasma lipids in children with diabetes mellitus].

The determination of unsaturation of lipids contained by the blood serum and cell plasma membranes, which depends on the total amount of double bonds (DB) in unsaturated fatty acids is a new and promising method of estimating lipid metabolism in diabetes mellitus. Unsaturation was determined by ozonization. 91 children aged 7 to 15 years were examined. The control group included 10 healthy children of the same age. The standardized values of unsaturation were delimited in the healthy children, which amounted to 260 +/- 20 conventional units. A relationship was discovered between DB and the degree of compensation together with the disease standing. Comparative analysis of blood DB and the lipid spectrum demonstrated that the high values of unsaturation correlate with elevated concentrations of free cholesterol, nonesterified fatty acids, cholesterol esters, pre-beta-LP, beta-LP and triglycerides.

Adolescent↗
PubMed1990

[Characteristics of hormonal homeostasis in children with thymus enlargement syndrome].

Hormonal homeostasis was examined in 104 children aged 1 to 14 years with thymus enlargement. There was a significant growth of somatotropic hormone in children of the first 3 years of life, characterized by thyroid dysfunction and hypofunction increase with age, by a tendency towards ACTH and hydrocortisone lowering under 6 years of age, and a significant decrease of those parameters in children over 6 years. The children with thymus enlargement also showed other disorders of hormonal homeostasis.

Adolescent↗
PubMed1989

[Vaccination against diphtheria and tetanus of children with thymus hyperplasia syndrome].

Inhibition of cellular and humoral immunity was established in children with grade I thymus enlargement syndrome (TES). The most pronounced changes were recorded in children aged 1-5 years. Vaccination against diphtheria and tetanus performed before the diagnosis of the TES was made were followed by satisfactory output of anatoxins, indicating the prospectiveness of the vaccination of the given children's group with DPT vaccine and DT- and DT-M-anatoxin.

Age Factors↗
PubMed1989

[Insulin requirements of patients with initial manifestations and decompensation of diabetes mellitus].

Altogether 100 children suffering from insulin-dependent diabetes mellitus were examined. Analysis of insulin requirement was performed in children with the first disease manifestation and in those with varying disease standing with regard to the type of insulin preparations used. According to the clinical observations, mono-component insulin preparations turned out absolutely superior in the attainment of diabetic process compensation in children with a comparatively low insulin requirement in the course of the treatment of the first disease manifestation and insulin requirement appreciably rose with the increase of the disease standing or superaddition of intercurrent diseases.

Adolescent↗