Biomedical subjects

M I Reunanen

Publications and source records attributed to M I Reunanen.

5 recordsLinked to original sources

PubMed1982

Spontaneous proliferation of cerebrospinal fluid mononuclear cells in multiple sclerosis. A longitudinal study.

Cerebrospinal fluid (CSF) and peripheral blood (PB) specimens from 32 MS patients longitudinally followed for up to 24 months and from a group of control patients without intrathecal inflammation were studied for the occurrence of activated lymphocytes with an autoradiography method. MS patients had higher numbers of proliferating mononuclear cells in CSF than did the controls, both during remission and exacerbation phases, whereas this difference was not found in the PB. ACTH treatment decreased the number of proliferating cells in CSF but had no effect on those of the PB of MS patients. A large variation in spontaneous proliferation of CSF cells was evident during the follow-up of individual patients, and there seemed to be no uniform correlation to the clinical fluctuations.

Adult↗

PubMed1979

Changes in serum triglyceride and cholesterol levels during long-term phenytoin treatment for epilepsy.

The effect of long-term phenytoin therapy on serum triglyceride and cholesterol levels in 20 patients with epilepsy was investigated. In patients followed up for six years, phenytoin treatment was associated with an increase in serum triglyceride and cholesterol levels. The most significant increases in lipid levels were measured during the first months of therapy, whereafter values generally tended to decrease. The elevation in serum triglyceride concentration was relatively greater than that in serum cholesterol level. Cholesterol concentrations, however, remained high for a longer period. The results demonstrate that phenytoin therapy for epilepsy is associated with a rise in serum triglyceride and cholesterol levels, the degree of which seems to be related to the duration of the treatment. The changes presumably reflect phenytoin effects on hepatic lipid metabolism.

Adolescent↗

PubMed1978

Proliferating cells in demyelinating states.

Proliferation of mononuclear cells was examined with an autoradiography method in the CSF and peripheral blood of 13 patients with multiple sclerosis (MS), serially during activation of disease in one patient with subacute sclerosis panencephalitis (SSPE), and in some control patients with various neurological conditions. High cerebrospinal fluid (CSF) cell labelling indices, up to 1.7%, which could not be directly related to the clinical activity of the disease, were found in some MS patients. During activation of SSPE there was marked increase in labelled cells of CSF, up to 4.3%. In controls, corresponding CSF indices ranged from less than 0.1% to 0.4%. Mononuclear cells in CSF and peripheral blood behaved as clearly different cell populations.

Adult↗

PubMed1977

Solid-phase radioimmunoassay detection of rubella virus IgG antibody in serum and CSF of patients with multiple sclerosis.

Low levels of rubella virus IgG antibody have been detected in cerebrospinal fluid (CSF) specimens of multiple sclerosis (MS) patients by a solid-phase radioimmunoassay (RIA) previously developed for testing of clinical serum samples. Paired serum and CSF specimens of 36 MS patients and 12 control patients were analyzed. Of those MS patients which had negative CSF titers in the rubella hemagglutination inhibition (HAI) test, 90% (11/12) were found to have rubella IgG antibody by the RIA method. In specimens found to contain rubella IgG antibodies by both methods, the RIA test was approximately 15 times more sensitive than the rubella HAI test. The results presented suggest that a considerable portion of MS patients have significantly reduced serum/CSF rubella IgG antibody ratios, indicating that there is a local production of rubella antibodies in the central nervous system of these patients.

Adult↗

PubMed1976

Serum calcium balance during early phase of diphenylhydantoin therapy.

The timing of anticonvulsant-induced disturbances of calcium metabolism was investigated in ten epileptics before diphenylhydantoin therapy and during it for up to three years. There was a significant decrease in average serum calcium and an increase in average serum alkaline phosphatase one month after the commencement of the therapy, these values remaining constant thereafter. Decreased serum inorganic phosphate and elevated hydroxyproline levels were also seen in the patients during the followup. At any time after the start of the drug therapy, 10 to 40 per cent of the patients had abnormalities in one or more of these parameters. The findings suggest that prophylactic therapy with vitamin D is indicated from the earliest phase of anticonvulsant therapy to prevent the development of bone disease.

Adolescent↗