[Cardiolipin antibodies in rheumatic polymyalgia and Horton's disease].
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Biomedical subjects
Publications and source records attributed to M I Rytikova.
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The authors describe the results of the follow-up of 59 patients with rheumatic polymyalgia. The observation period lasted from 6 months to 6 years. The clinical manifestations of the disease have been analyzed. The torpid and steroid-independent variants of the disease have been distinguished, 22 patients (37.3%) manifested arthritis of different joints, characterized by an insignificant number of damage joints, little intensity of local inflammation, rapid and steady abatement after the treatment with corticosteroids. 10 patients (16.9%) with rheumatic polymyalgia had the carpal canal syndrome and 5 patients (8.5%) diffuse painless hand edema. The symptoms of Horton's disease were revealed in 19 patients (32.6%).
Human and animal blood smear staining with PAPh has revealed mononuclear leukocyte-erythrocyte aggregates. Administration of retinoic acid increased concentration and dimensions of these aggregates and was followed by preferential accumulation of PAPh-negative osmotically unstable erythrocytes. Similar changes were detected in the blood samples of women engaged in the production of retinoic acid. Aggregate concentration showed positive correlation with erythrocyte sedimentation rate and no correlation with prothrombin time.
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