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Biomedical subjects

M I Sacks

Publications and source records attributed to M I Sacks.

At least 19 recordsLinked to original sources
PubMed1983

Testicular lymphoma. A retrospective review of 17 cases.

Seventeen cases of testicular lymphoma were reviewed retrospectively in order to study the relationship between histological appearances, clinical presentation and prognosis. Thirteen of the patients were adults, all over 60 years of age, and 4 were children. Twelve patients were White, 2 Black and 3 of mixed racial descent. All cases were diffuse non-Hodgkin's lymphomas, 9 being intermediate and 8 high grade according to the 'working formulation' of the National Cancer Institute of America. Histological type, mitotic count, histiophagocytosis, vascularity, extent of necrosis and degree of fibrosis did not influence survival. The stage of the disease was the most important prognostic factor, patients in stage IE having an excellent prognosis. Extension to extratesticular sites was associated with a poor prognosis regardless of the stage of the disease.

Aged↗
PubMed1980

Clustering of Hodgkin's disease in Israel: a case-control study.

The geographical distribution of Jewish patients in Israel with HD diagnosed between 1960 and 1972 differed significantly from that of individually-matched population controls. Significant clustering occurred in 3 regions of the country. The odds ratio expressing the greater tendency of patients to have lived in one of these regions 5-9 years before the diagnosis, as compared with that of their paired controls, was 2.4. The association with residence in a higher-risk region was not significantly modified by sex, age, period of immigration, region of birth, father's region of birth, or date of diagnosis. The association was weaker for cases with nodular sclerosis than for those with other subtypes of HD. The clustering could not be explained by available data on the characteristics and prior experience of the cases and controls. There was a significant correlation between the risk of HD in a region and the proportion of native Israelis in its Jewish population, but there were no significant correlations with a variety of other demographic, natural and socioeconomic features of the regions. There was no significant time-space interaction. The findings suggest that susceptible people living in certain parts of the country during the 1950's and 1960's had a somewhat enhanced risk of HD because of exposure to unidentified environmental factors active in those regions at that time.

Adolescent↗
PubMed1979

Effect of dibromochloropropane on human testicular function.

Severe impairment of spermatogenesis was found in 18 (78%) of 23 workers after exposure to 1,2-dibromo-3-chloropropane (DBCP). Azoospermia associated with elevated plasma follicle-stimulating hormone was diagnosed in 12 workers whose exposure time to DBCP varied from 100 to greater than 6,000 h. Oligospermia and normal plasma follicle-stimulating hormone were found in six employees with exposure times between 34 and 95 h. Plasma luteinizing hormone, testosterone and thyroxine were within the normal range. Testicular biopsy showed selective atrophy of the germinal epithelium, intact Sertoli cells and normal appearance of Leydig cells. The mechanism and potential reversibility of these testicular changes are still to be evaluated.

Adult↗
PubMed1978

A case-control study of Hodgkin's disease in Israel.

Jewish residents of Israel in 1960-72 with Hodgkin's disease (HD) were compared with controls drawn from the general population. The controls were individually matched by sex, age, origin, and date of immigration. The comparison showed a significant association between HD and parental consanguinity and pointed to the possible etiologic role of recessive inheritance. Females with HD tended to have a lower parity than did their controls. Associations between HD and a high educational level and the presence of a flush toilet in the childhood home were significant and gave limited support to the hypothesis that a high standard of living in childhood increases the risk of subsequent HD. Tonsillectomy and a history of work with wood or trees were significantly associated with mixed cellularity but not with other histologic subtypes. Differences between patients with HD and controls with respect to cigarette smoking, exposure to animals, marital status, previous blood transfusions or jaundice, contact with asbestos, residual or occupational mobility, or other characteristics were not significant.

Adolescent↗