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Biomedical subjects

M I Sulaiman

Publications and source records attributed to M I Sulaiman.

6 recordsLinked to original sources

Periodontal treatment needs among Saudi Arabian adults and their relationship to the use of the Miswak.

The main aims of this study were, first, to estimate the need for periodontal care among adult residents of Saudi Arabia using the community periodontal index of treatment need (CPITN) and, second, to quantify the relationship between the frequency of using the 'Miswak' and the need for periodontal care. The Miswak is a stick made from the roots of the Arak tree (Salvadora persica) and is used for oral hygiene purposes by many cultures. A total sample of 480 adults aged 35 to 44 years and 65 years and older from the cities of Mecca and Jeddah was included in the study. The findings indicate that the level of need for periodontal care in the sample chosen is low when compared with the findings of similar studies undertaken in other countries. The frequent use of the 'Miswak' was associated with a lower need for treatment.

Adult↗

Effect of schistosomiasis mansoni on open-field exploratory behavior in mice.

The response of mice infected with Schistosoma mansoni to a novel environment has been investigated in an attempt to study the effects of the disease on brain cognitive function by using opto-varimix instrument and autotrack computer program. Two to 18 weeks infected mice showed lower ambulatory activities than their matched controls with the largest reduction occurring between weeks 6 to 10. Maximum effects were observed in week 8. The first 5 minutes of ambulatory activities, designated as the "first session", were 22.3% lower in infected mice as compared with controls. The decline in the first session activities of infected mice was slower than the controls. Infected mice showed fewer stereotype movements with maximum reduction in week 16 of infection. There was no correlation between mice ambulatory activities or stereotype movements and infection duration. The importance of these findings in relation to the course of the disease and the underlying mechanism(s) are discussed.

Animals↗

Application of transformation algorithm and nonparametric calculation in determining the reference intervals of some urine constituents and characteristics.

We have applied a multi-stage computer algorithm for normalization of distributions and calculation of reference intervals of some urine characteristics and constituents. The study analyzed 24-h urines, collected from adult male Saudis from different socioeconomic classes, for volume, pH, osmolality, specific gravity, creatine, creatinine, urea and uric acid. Frequency distributions, for each analyte, were found to be nongaussian as judged by the coefficients of skewness and kurtosis, chi 2 and Kolmogorov-Smirnov tests, and from probability plots. Data were transformed to gaussian distributions by multistage log-power transformation. Stepwise, this procedure removed skewness and residual kurtosis. Using the gaussian transformed data the reference intervals were estimated parametrically as the mean +/- 2 SD. In addition, the non-parametric percentile technique was applied to estimate these values. The former intervals were found to have narrower 0.90 confidence limits than the latter. When established limits were compared with those reported for Western subjects urine volume and uric acid showed the most marked variation.

Adult↗

Effects of Salvadora persica extracts on mice exploratory locomotion activities.

The effects of Salvadora persica extracts on mice exploratory locomotor activities and stereotype movements have been determined. Mice injected with Salvadora persica extracts showed significantly low exploratory locomotor activity. The total distance travelled by naive mice injected with saline, during the first 5 min of introduction into an activity cage (Session 1) was 1007 +/- 105 cm/5 min, in contrast to 800 +/- 75, 540 +/- 100 and 330 +/- 55 cm/5 min for naive mice injected i.p. with 5.7, 14.3 and 28.6 ml/kg Salvadora persica extract. The exploratory locomotion of Salvadora persica treated mice declined faster than that of the controls. Mice injected with Salvadora persica extract also showed a significantly lower number of stereotype movements (P less than 0.05). The stereotype movements of the control was 175 +/- 5 movements/5 min and 90 +/- 10, 118 +/- 15 and 35 +/- 11 for mice injected with 5.7, 14.3 and 28.6 ml/kg, Salvadora persica extract, respectively.

Animals↗

Relevance of plasma, glandular and urinary kallikrein in renal hypertrophy in streptozotocin-diabetic rats.

The relevance of plasma, glandular and renal kallikrein as an intrarenal hemodynamic regulator, in renal hypertrophy, in 1-5 weeks streptozotocin diabetic rats has been investigated. The fasting plasma glandular kallikrein level significantly decreased with increasing duration of diabetes (p less than 0.05). Glandular kallikrein correlated negatively with kidney weight (r = 0.76, p = 0.05). The 24 hour urinary kallikrein excretion significantly increased with increasing duration of diabetes (p less than 0.05), but this level was not correlated with glucose level, nor with kidney weight. Aprotinin (a kallikrein inhibitor) injected (10 X 10(3) KIU/kg) twice daily for 2 weeks in diabetic rats, significantly decreased plasma glucose levels by 28%, 24 hour urinary kallikrein by 37% (p less than 0.05) and kidney weight by 6%. These results suggest that plasma, glandular and renal kallikrein did not play an important role in the renal hypertrophy observed in streptozotocin diabetic rats.

Animals↗