Severe and protracted diarrhea.
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Diarrhea, Infantile↗
Biomedical subjects
M I el Mouzan
Publications and source records attributed to M I el Mouzan.
Secondary school and admission test grades as predictors of performance of medical students.
The performance of three consecutive classes of students admitted to the Colleges of Medicine and Medical Sciences at King Faisal University was studied. All students took the high school graduation examination and sat the college admission test. It was found that performance on the admission test was a better predictor than high school grades in the first two levels of the medical curriculum. However, performance in a combination of certain high school and admission test subjects was a more powerful predictor of students' achievement at all levels. This study indicates that the college admission test is a useful additional tool in the process of medical student selection at this college. Further studies are needed, however, for the formulation of general recommendations.
College Admission Test↗
Cow's-milk-induced erosive gastritis in an infant.
A 3 1/2-month-old male infant presented with hematemesis due to erosive gastritis following whole-cow's-milk feeding. The presence of eosinophilic gastritis, the disappearance of symptoms after withdrawal of whole-cow's-milk feeding, and the association with facial eczema suggest that gastritis was induced by cow's milk. Cow's-milk intolerance should be considered in the etiologic differential diagnosis of hematemesis and gastritis in infancy.
Animals↗
Clinical features of sickle cell disease in eastern Saudi Arab children.
The clinical features of sickle cell disease (SCD) in Saudi Arab children of eastern origin are presented. One hundred and seventy-three children were diagnosed at birth and followed prospectively from 3 months to up to 4 years of age. There were 87 boys and 86 girls. Genotype distribution included 146 sickle cell anemia, 24 sickle beta +-thalassemia, two sickle beta 0-thalassemia, and one sickle hemoglobin C disease. Of our patients, 7% presented in the first 12 months of age and 27% remained asymptomatic at 4 years. Painful crises of bones and joints were the most common initial symptoms, followed by dactylitis, abdominal crises and acute splenic sequestration (ASS), occurring in 60%, 31.6%, 6.7%, and 1.7% of the patients, respectively. None of the patients presented with severe bacterial infections. During this study, 175 sickle cell crises were documented, but only 16 (9.1%) required hospital admissions. There were no deaths in this series. High hemoglobin F levels correlated with delayed clinical presentation and reduced number of crises. We conclude that SCD in children of eastern origin is clinically milder than earlier descriptions from the Eastern Province of Saudi Arabia.
Anemia, Sickle Cell↗
Infections and sickle cell disease in Eastern Saudi Arabian children.
The rate and pattern of infections in 144 Saudi Arabian children with sickle cell disease (SCD) and matched normal control subjects are reported. All diagnoses of SCD were made at birth by means of screening blood from the umbilical cord. The children were prospectively followed up from birth to 4 years of age. Severe bacterial infections occurred in none of the children with SCD; one of the control children developed pneumococcal meningitis. Acute gastroenteritis was significantly more common among patients with SCD. For the first year of life, patients with SCD had significantly more infections than did the control children; but the reverse was true in the group that was 37 to 48 months of age. Considering all types of infections for all age groups, no difference was noted between patients with SCD and control subjects in terms of infection rate or related hospital admission. There were no deaths caused by infection in this series. We conclude that Saudi Arabian infants and young children of oasis origin with SCD are not at increased risk of infections compared with healthy children of the same age.
Anemia, Sickle Cell↗
Variability of sickle cell disease in the Eastern Province of Saudi Arabia.
The clinical and hematologic features of sickle cell disease in two groups of patients of different ancestral origin, but living in the Eastern Province of Saudi Arabia, are presented. Twenty-eight patients of southwestern origin were matched for gender, age, and diagnosis with an equal number of patients of eastern origin. The disease was diagnosed in all patients at birth, and follow-up study was done on a regular basis. Despite being born and living in the same environment (Eastern Province), patients of southwestern origin had more severe clinical features, consistently lower hemoglobin levels, and higher reticulocyte counts, suggesting more severe hemolysis. We conclude that there are at least two distinct forms of sickle cell disease in the Eastern Province of Saudi Arabia and that the variability of the disease in early childhood is more likely related to genetic than to environmental factors.
Age Factors↗
Pattern of pediatric gastrointestinal disorders in the eastern province of Saudi Arabia.
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Child↗
The syndrome of osteopetrosis, renal acidosis and cerebral calcification in two sisters.
The syndrome of osteopetrosis associated with renal tubular acidosis and cerebral calcification, inherited as an autosomal recessive disorder, as seen in two sisters, is described. The primary defect in this rare syndrome is deficiency of carbonic anhydrase (CA) II. Significant reduction in blood levels of CA II were found in both parents and another sister, suggesting that these individuals are heterozygotic carriers.
Acidosis, Renal Tubular↗
Myelofibrosis and pancytopenia in systemic lupus erythematosus.
A 13-year-old Saudi girl presented with severe clinical features of systemic lupus erythematosus of 3 months' duration. In addition to laboratory evidence of the disease, the patient was found to have pancytopenia and myelofibrosis. While pancytopenia was considerably improved by steroids, myelofibrosis was not reversed. The coexistence of myelofibrosis and pancytopenia in patients with systemic lupus erythematosus has been reported, but their possible causal relationship remains unresolved.
Adolescent↗