PubMed Health⌕ Search

Biomedical subjects

M Iancu

Publications and source records attributed to M Iancu.

11 recordsLinked to original sources
PubMed1983

Medical nephrectomy: the use of metallic salts for treatment of end stage massive proteinuria and renal hypertension.

The first two cases outlined above with intractable massive proteinuria and uremia, were followed and treated with standard medical therapy and dialysis. After a period of study and demonstration of clinical deterioration both patients were given solutions containing sodium mercaptomerin. Within days there was a decline in urine protein excretion and a variable increase in serum protein concentration. The patients demonstrated an increase in blood pressure, which made hemodialysis treatment possible. No deleterious effects from the mercury salts were noted. These observations suggest that in selected cases nephrotoxic agents may be of value in decreasing massive proteinuria, and improving protein homeostasis in uremic patients. The ideal agent should be non-toxic to other organs and produce selective renal ablation (15). Although mercury is not the ideal agent, in these cases it did not produce observable side effects. This new method, applicable to dialysis patients with massive proteinuria, and of help in the control of uncontrollable hypertension in uremia, is an interesting new approach for our therapeutic armamentarium.

Aged↗
PubMed1982

Pancreatic disease in uremia and parathyroid hormone excess.

To assess the coexistence of pancreatic alterations and elevation of parathyroid hormone (PTH) as contributors to morbidity, a study correlating evidence of histological pancreatitis with elevated PTH has been undertaken. A retrospective autopsy study of pancreatic histology in 21 patients who died during maintenance hemodialysis (MD) (group I) compared their level of serum PTH with a group of patients who died without historical or clinical evidence of renal insufficiency (group II). Each patient in this group had creatinine clearance of less than 5 ml/min and had been treated with hemodialysis from 4 to 120 months preceding death. There was a difference in the incidence of histological and PTH levels between groups I and II. A total of 15 out of 21 (71.4%) of group I patients had severe pancreatic disease. By contrast, none of the group II control patients had marked pancreatic disease (p less than 0.01). Also a statistically different demarcation was present between groups I and II on the basis of PTH levels. Group I patients with pancreatic disease (n = 5) had a higher PTH level (567 +/- 76 pg/ml) than those (n = 6) without diseased pancreata (218 +/- 6.5 pg/ml). These data infer that a possible correlation between measured iPTH excess and histological alterations in pancreas may exist.

Adult↗
PubMed1980

An outbreak of Salmonella enteritis and septicemia in a population of uremic patients. A review of four cases, including infection of an arteriovenous fistula.

An outbreak of enteritis and septicemia caused by Salmonella enteritidis occurred in a population of uremic patients treated in a nephrology unit. In one of the patients, an arteriovenous fistula was infected by this organism. The source of the outbreak was traced to the refrigerator and sink in the unit. This degree of morbidity and mortality far exceeds that previously reported in infections with nontyphoid Salmonella sp and is presumbly related to the decreased immune response seen in uremia.

Adult↗
PubMed1976

Metabolic changes in diabetic uremic patients on hemodialysis.

By studying the metabolic values of a nondiabetic and diabetic uremic population we demonstrated the following: 1. Insulin is higher in diabetic than nondiabetic uremic patients. A slight arteriovenous difference across the dialyzer membrane suggests that insulin is dialyzable in small amounts in man. 2. C-peptides are highest in nondiabetics, lower in maturity onset diabetics, and lowest in juvenile diabetics. 3. Growth hormone is higher in diabetics than nondiabetics, decreased in both groups during hemodialysis, and returns to pre-dialysis levels 2 hrs after the completion of dialysis treatment. 4. Plasma triglycerides are elevated in both popualtions during the fasting state anddrop during hemodialysis, rising slowly towards the end of hemodialysis. 5. The majority of diabetics on hemodialysis have low renin levels and do not respond to volume reduction. In the high renin diabetics and high and low renin nondiabetics the plasma renin levels rise in response to volume reduction during hemodialysis. Renin is not dialyzable in man. 6. Thyroid function tests show that diabetic and nondiabetic patients have measurements in the low normal range. Our results reveal significant information concerning metabolic changes which take place in diabetic and nondiabetic uremic patients on hemodialysis and helps to characterize these populations. This report may have implications in better understanding the nature of the problems encountered in these populations and in their management (Table III).

Adult↗