[Establishment of continuous infusion system via hepatic artery or portal vein of the rat].
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Animals↗
Biomedical subjects
M Imajo
Publications and source records attributed to M Imajo.
[An experimental study on portal infusion of 5-fluorouracil (the second report)].
This study was conducted to clarify the role of continuous portal infusion with 5-fluorouracil (FU) from two different standpoints. Experiment I (Assessment of the ability to reduce hepatic metastasis): Male Donryu rats (180-210 g) receiving intraportal inoculation of ascites hepatoma AH 60 C (4 x 10(6) cells) were divided into 3 groups; portal infusion group, venous infusion group and control. 5-FU (20 mg/kg/day) was continuously infused via either the portal vein or the femoral vein with heparin (100 U/kg/day) for 5 consecutive days. The portal infusion group alone showed a significant decrease in hepatic tumor volume on day 21 and prolonged survival time. Experiment II (Evaluation of the immunological effects): Animals without inoculation of AH 60 C were also randomized in the same way as Experiment I. There were no statistical differences among the 3 groups in total leukocyte counts, lymphocyte subpopulations or NK activities in the spleen, whereas hepatic NK activity was significantly decreased in the portal infusion group. Continuous portal infusion with 5-FU is considered effective to prevent lodging of tumor cells in the intra-hepatic portal system but might be disadvantageous for hepatic cellular immunity.
Animals↗
Coombs-positive autoimmune hemolytic anemia in ulcerative colitis--a report of two cases.
Two cases of ulcerative colitis with a positive Coombs test are reported herein. In a 30 year old woman, hemolytic anemia was well controlled by excision of a rectal stump left over from a former operation. A 53 year old woman had a positive Coombs test without clinical hemolytic anemia 10 years after undergoing a total procto-colectomy with ileo-anal anastomosis. Thus we concluded that total procto-colectomy may be preventive, as well as therapeutic, for Coombs positive hemolytic anemia associated with ulcerative colitis.
Adult↗
Tracheo-bronchitis as a complication of Crohn's disease--a case report.
A case of Crohn's enterocolitis associated with diffuse tracheo-bronchitis is presented herein. Although respiratory tract involvement in Crohn's disease is extremely rare, our review of the world literature revealed several common clinical pathologic features. These features include a productive cough with chest X-ray films which are normal except for some peripheral involvement. Bronchoscopy, however, shows diffuse inflammation of the trachea and bronchi with widely scattered whitish lesions while biopsy reveals a granulomatous infiltration of inflammatory cells. This tracheobronchitis typically responds well to treatment with prednisone.
Adult↗
[An experimental study on portal infusion of 5-fluorouracil].
We conducted these experiments to investigate the differences between continuous portal and one shot portal infusion of 5-fluorouracil (5-FU) using male Donryu rats. Continuous portal infusion of 5-FU (20 mg/kg/day x 5 days) revealed no remarkable side effects on the rats with significant decrease in the number of liver metastases generated by intraportal inoculation of ascites hepatoma AH60C. Consecutive 5-day administration of 5-FU (20 mg/kg x 5) by one shot method via spleen resulted in no metastases but caused death in 75% of rats because of severe leukopenia and dehydration. The rats receiving one shot infusion of 5-FU (33.3 mg/kg x 3, day 1, 3, 5) via spleen showed a significant decrease in the number of metastases without lethal side effects. Continuous portal infusion of 5-FU would be a safe and effective therapy to prevent liver metastases, whereas one shot portal infusion of 5-FU may give rise to severe side effects while preventing liver metastases.
Animals↗
[A case of rectal carcinoma disappeared by the preoperative radiation].
A 64-year-old man was admitted to our department with a diagnosis of rectal carcinoma. Preoperative histological diagnosis was highly differentiated adenocarcinoma of Dukes' A classification (Rb', Is', 20-25 mm in diameter, PM'). Preoperative radiation (2.5 Gray/time, total 30 Gray) and chemotherapy (PSK 3g/day x 3 weeks, ACNU 30 mg/m2/week x 3 weeks) were performed on this lesion. After these therapies, form of the tumor changed to IIa', SM', which was recognized by endo-scopic examination with rectal echography. A reduction of the size was 25%. Low anterior resection, curative operation, was performed 2 weeks after the therapy. The resected rectum was examined in detail, resulting in complete disappearance of the carcinoma cell and the tumor was replaced by the inflammatory cells, fibroblasts and granular cells. These findings were compatible with grade IVB of Ohboshi-Simosatos' classification.
Adenocarcinoma↗
[Experimental studies on drug concentrations in the liver using intra-hepatic injection of anticancer drug in combination with temporary halting of abdominal blood flow].
In a case of CDDP of 5 mg/kg injection for 5 min via the hepatic artery of non-tumor bearing rat, we assessed the influence of concomitant aortic clamping for 5 min at the intraphrenic level, which resulted in a decrease in the portal blood flow. CDDP-Platinum concentrations in the liver of rats given CDDP injection plus aortic clamping were 20.7 +/- 1.6 micrograms/g, which was two times higher than that (10.1 +/- 1.7 micrograms/g) of rat given CDDP injection alone. This enhanced CDDP-platinum concentration remained 15, 30, and 60 min after injection, respectively 1.4, 1.4 and 2.1 times higher. On the other hand, CDDP-platinum concentrations in the kidney of rats given CDDP injection plus aortic clamping were 4.5 +/- 0.8 micrograms/g, only one tenth of that (49.7 +/- 3.4 micrograms/g) of rats given CDDP injection alone. At 15 and 30 min after injection, there was no significant difference in CDDP-platinum concentrations in the kidney between these two groups. Renal toxicity observed in the group given CDDP injection plus aortic clamping was significantly less than in the group given CDDP injection alone, while hepatic toxicity seen in the former group was the same as that in the latter one.
Animals↗
Self washout method for defecational complaints following low anterior rectal resection.
A self washout method was performed by ten patients who had defecational complaints following an anterior resection. A commercially available colostomy washout set was used for this procedure. When the patient sat down, the cone tip of the set was pressed into the anal canal by pushing the cone with the palm of the hand. The volume of water for irrigation used was 500 to 1000 ml and the subsequent defecation time was from 20 to 50 minutes. In all cases, the frequent urge to defecate disappeared and after normal defecational function had been recovered, the self washout was able to be discontinued.
Adult↗
[Portal vein infusion therapy of the prevention of liver metastasis from colorectal carcinomas].
For patients who underwent curative resections for primary colorectal carcinomas, locally recurrent tumors and metastatic liver tumors, we applied portal vein infusion therapy to prevent further metastases to the liver. Following radical resection of the tumor, dissecting the umbilical vein from the falciform ligament made it possible to recanalize and insert a 18 G catheter into the portal vein. Intraportal chemotherapy (5-FU 750 mg/day) was carried out for the first 7 postoperative days. There were 17 patients who received this therapy, 10 with curative resection for the primary cancers, 1 with curative resection for the locally recurrent tumor and 7 with the curative resection for the metastatic liver tumors. The follow-up period is rather short (17 months) but no patients have had the liver metastases. So we suggest that this adjuvant liver infusion may reduce the liver metastases without any mortality or morbidity.
Adult↗
Ovarian clear cell adenofibroma of borderline malignancy. A case report.
A case of ovarian clear cell adenofibroma of borderline malignancy in a 59-year-old woman is presented with histochemical and electron microscopic observation. The tumor was histologically composed of tubular component lined in part with flat or cuboidal clear as well as hobnail cells with mild cytologic atypia and abundant stromal component containing foci of calcification. The epithelial cells had diastase-digestive PAS-positive material in the cytoplasm, and occasionally the luminal surface and intraluminal substance were stained with mucicarmine. Some of the epithelial cells showed positive lipid staining with Sudan III stain. On ultrastructural study, the tumor featured a moderate number of small mitochondria, poorly developed rough endoplasmic reticulum (rER), short microvilli, intercellular tight junction and desmosome and small amount of glycogen granules. The patient is alive and well with no evidence of recurrence six and half years after the operation.
Adenofibroma↗
[Long-term pathophysiological studies on loop ileostomy and ileoanal anastomosis].
Mucosal proctectomy with ileoanal anastomosis (IAA) had been performed on 37 patients with adenomatosis coli and 16 with ulcerative colitis between 1978 and 1987. These patients were followed up for a mean of 7.5 years. In 38 cases (73%), this procedure was completed by closure of loop ileostomy. The mean number of bowel movements per 24 hours was 6.0. Seven patients had occasional episodes of minor nocturnal soiling. The postoperative maximum resting anal pressure was the most important parameter reflecting clinical results and it rose from 72 to 92 cm of water during 5.3 year follow-up period after IAA. The pathophysiological studies on loop ileostomy and IAA were performed in these patients. Postoperative small bowel transit time evaluated by radioopaque markers was shortened. Daily output of water and sodium, and Na/K ratio in the ileal excreta increased and total counts of anaerobes in feces decreased. On the other hand, daily volume, Na/K ratio and PH of urine fell significantly. These phenomena were remarkable in patients who received loop ileostomy with about 60 cm defunctioning terminal ileum. These results indicate that it is necessary to maintain intestinal continuity in the ileal pouch-anal procedures.
Adolescent↗
[A case report of uterine carcinosarcoma with alpha-fetoprotein (AFP) production].
A case of carcinosarcoma, mixture of endometrial stromal sarcoma and adenocarcinoma, of the uterus with alpha-fetoprotein (AFP) production in a 69-year-old woman was reported. By the results of serum AFP levels (preoperative: 2,950.0 ng/ml, post-operative and chemotherapy: 2.1 ng/ml) and immunohistochemical localization of AFP, the AFP was thought to be produced from this tumor. Immunoreactive AFP was found in the carcinomatous components and no AFP was present in the sarcomatous components at all. It seems from this that immunohistochemical study supports the composition theory of mixed mullerian sarcoma of the uterus.
Aged↗
[Urinary calculi associated with total proctocolectomy].
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Adenoma↗
Histology of the healing process after total colectomy, mucosal proctectomy and ileo-anostomy.
Total colectomy, mucosal proctectomy and ileo-anostomy were performed on 10 dogs to observe the healing process of the space between the rectal muscle cuff and the pulled through ileum. Adhesion was complete in six cases. The ileal and rectal muscle layers were well preserved, but two weeks after the surgery the healing was not completed. One month after the operation, there was little scar formation between the rectal muscle cuff and the ileum, in the absence of infection. If there was infection between the ileum and the rectal muscle cuff, abscess and scar formation was seen even one month after the operation. This operation is thought to be rational from a histological viewpoint and the most important factor is the prevention of infection in the space between the ileum and rectal muscle cuff.
Abscess↗
[Management and nursing care following extensive excision of the large intestine--with special reference to ileostomy].
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Colonic Diseases↗
Total colectomy, mucosal proctectomy, and ileoanal anastomosis.
A safe and practical procedure for total colectomy and mucosal proctectomy with ileoanal anastomosis has been developed and performed by us on 11 patients with adenomatosis coli and two patients with ulcerative colitis. The major features of the operative procedure are 1) total removal of the rectal mucosa to just above the dentate line; 2) preservation of anorectal function by a long rectal cuff procedure achieved by rectal mucosal excision from a level just below the sacral promontory, using a rectal internal stent and gauze packing techniques for rectal mucosal stripping, with, in some patients, an ileal reservoir added; and 3) prevention of pelvic sepsis by intraoperative rectal irrigation, rectal cuff drainage, and a temporary defunctioning loop ileostomy. Of six patients with at least three months of follow-up after reconstruction, each has returned to normal life, averaging two to seven semiformed stools each day. A side-to-end ileoanal anastomosis with a low-lying, loop-type ileal reservoir provided the best functional results.
Adenoma↗