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Biomedical subjects

M Imbriani

Publications and source records attributed to M Imbriani.

At least 109 records · Page 6Linked to original sources

Allergic cutaneous diseases in hairdressers.

BACKGROUND: Hairdressers are commonly exposed to water, irritants, sensitizers, and are at risk of occupational skin diseases. Several cases of allergic contact dermatitis and contact urticaria in hairdressers have been described over the last few years. OBJECTIVES AND METHODS: The paper aims to report occupational agents which can induce allergic cutaneous diseases in hairdressers; moreover an analysis of the literature was carried out to review data concerning epidemiology, clinical evaluation, management and prevention. RESULTS AND CONCLUSIONS: Hairdressing carries a high risk of skin damage, especially for the hands. Allergic contact dermatitis is the most common disorder. Training represents a risk factor, while the role of atopy and nickel sensitivity as etiological agents is controversial. A great number of chemicals may induce allergic cutaneous diseases in hairdressers, such as nickel, thioglycolate, p-phenylendiamine (and other dye-related substances), persulphates, quaternary ammonium compounds, protein hydrolysates, surfactants, cyanoacrylates, latex, rubber haptens and others. Avoidance of further contact with the identified causal sensitizer(s) is the most important measure for management and prevention; to this end, a number of specific preventive strategies should be implemented.

Barbering↗

[The significance of enviromental and biological monitoring in workers employed in service stations after the elimitation of tetraethyl lead from gasoline].

The chemical risk in service stations may be due to toxic compounds present in fuel (particularly benzene and additives) and to the emission of exhausts and fine particulate from vehicles. Owing to the elimination of lead (Pb) from fuel and to the necessity of lowering CO emission, several oxygenated additives have been added to fuel, in particular methyl-tert-butyl-ether (MTBE), whose toxic properties are at present under investigation. The introduction of reformulated gasoline (RFG) and the use of catalytic converters (with possible release of platinum (Pt) in the environment) may have modified the risks for workers employed in service stations. The paper shows data collected from 26 subjects (divided into three specific tasks, namely: fuel dispenser, "self-service" attendant and controller, and cashier) to estimate the actual chemical risk and to compare it with the previous data taken from literature. For this purpose, besides performing the usual medical surveillance, we measured the environmental concentrations of benzene, MTBE and formaldehyde, the urinary levels of benzene metabolites S-phenylmercapturic acid (S-PMA) and t,t-muconic acid (MA) and of unmodified MTBE, and the blood concentrations of Pb and Pt for each subject. Mean values of these compounds were, respectively: 38.81 microg/m3; 174.04 microg/m3; 10.38 microg/m3; 2.36 microg/g creatinine; 96.57 microg/g creatinine; 1.41 microg/L; 7.00 microg/100 mL; 0.0738 ng/ml. The above values were much lower than the corresponding limit values reported by ACGIH and DFG. In particular, after the introduction of vapour recycle systems and the widespread use of "self-service" systems, airborne benzene concentration dropped from 300/400 microg/m3 to lower than 100 microg/m3, without noticeable increasing of exposure to formaldehyde. The disappearing of Pb from gasoline leads to a progressive lowering of its blood levels, while the possible risks due to the very low amounts of Pt released from catalytic converters have still to be defined exactly. Taken all in all, our results seem to indicate that, after the elimination of tetraethyl lead, the chemical risk for workers employed in service stations is now lower than in the past.

Air Pollutants, Occupational↗

[Indoor air quality in an Italian military submarine].

In recent years there has been increasing interest on studies concerning indoor air quality and focusing on risk factors for exposed subjects. Particularly, airborne chemicals, whose adverse effects are well known, have been identified and determined in means of transport as in other indoor places. As concerns chemical air concentrations in submarines, only a limited number of studies have been published. This paper reports measured concentration data for organic compounds (total volatile organic compounds, substances with a chemical bond S-O, nitrogen compounds, carbon monoxide, carbon dioxide, and different organic solvents) in the air sampled during an 8-h period in an Italian Military submarine, under routine operations. We observed that a periodicalfresh-air intake operation (snorkel) might cause temporary increase of contaminants levels in indoor air. Moreover, we could find that pollutants sometimes reach notable peak concentrations being potentially able to induce adverse health effects in crewmembers. Our data highlight the need to promote further investigations.

Air Pollutants↗

[Recent prevention strategies and occupational risk analysis: Control Banding and Sobane].

Employers are responsible for the prevention of risks and must provide for the safety and health of their workers. They are obliged to apply the general principles of prevention: to avoid, where possible, any risk; to characterize and hence to estimate residual risks; to eliminate risks at the source; to adjust jobs to the needs of workers and not workers to the jobs. When we pass to the practical performance of these shared principles we introduce many problems: problems concerning terminology; problems in estimating the nature of the risks that are faced; coordination problems between the subjects that preside over prevention; problems arising from the different typology of the companies investigated In order to answer these questions the "Industrial Hygienists" have long since created various strategies for the prevention and control of risks. Among different models the methods Control Banding and Sobane-Deparis are undoubtedly the most promising. Control Banding is designed to assist especially Small and Medium Enterprises in complying with the chemical safety regulations, the scheme uses the R phrases that in Europe must be assigned to potentially harmful chemicals by the manufacturer of the chemical. R phrases describe the most important harmful effects of a chemical and have been adopted in many non European countries also. The combination of the hazard classification of the chemical and assessment of the exposure potential will allow understanding of the level of risk thus leading the person carrying out the assessment to an appropriate control method. Occupational hygienists with experience of assessing occupational exposure to chemicals agreed parameters that could be used to give reasonable indications of exposure potential. One of them is quantity being used and three categories--small, medium and large--are defined. The likelihood of the chemical becoming airborne has been addressed by defining solids according to levels of dustiness and liquids according to volatility. A simple graph that uses the boiling point of the chemical and the process operating temperature assigns the chemical a high, medium or low volatility rating. The user now has enough information to identify the control approach required to adequately reduce exposures to the chemical Occupational hygienists agreed on three broad control approaches: General Ventilation; Engineering Control; Containment. However it is recognised that in some cases specialist advice will be needed. The user takes the hazard group, quantity and level of dustiness/volatility and matches them to a control approach using a simple table. The controls are described in control guidance sheets, which comprise both general information and, for commonly performed tasks, more specific advice. The second section of the document describes a risk-prevention strategy, called SOBANE, in four levels. These four levels are: screening, where the risk factors are detected by the workers and their management, and obvious solutions are implemented; observation, where the remaining problems are studied in more detail, one by one, and the reasons and the solutions are discussed in detail; analysis, where, when necessary, an occupational health (OH) practitioner is called upon to carry out appropriate measurements to develop specific solutions; expertise, where, in very sophisticated and rare cases, the assistance of an expert is called upon to solve a particular problem. The method for the participatory screening of the risks, Deparis, is proposed for the first level screening of the SOBANE strategy. The aim of Sobane strategy is to make risk prevention faster, more cost effective, and more effective in coordinating the contributions of the workers themselves, their management, the internal and external OH practitioners and the experts.

Chemical Industry↗

[Research and formal demonstration of evidence of efficiency in occupational medicine].

There is an increasing pressure on occupational health professionals to ensure that their practice is based on a quality standard and an evidence of appropriateness. The efficacy-effectiveness of their activity strictly depends on their intellectual and professional integrity, their technical and legal competence, but also on the quality of the relations with the company organisation they are able to establish. We asked to some occupational physician when they considered their interventions in the workplace to be efficacious. Then, accordingto our epexrience, we propose some effectiveness indicators, particular concerning health surveillance and health educttaon, that should be evaluated to verify the health professional agccvity agreement to quality standards.

Cost-Benefit Analysis↗

[Occupational risk and prevention in the biotechnology industry: a review].

BACKGROUND: The biotechnology industry has expanded greatly in the last 20-30 years and has led to a number of applications in different sectors of work, i.e., medical and pharmaceutical, agricultural, chemical, energetic and others. Nowadays hundreds of thousands of workers worldwide are employed in biotechnology plants. Health and safety issues related to such working activities are considered as relevant to workers as well as to the general public. In particular, when compared to traditional biotechnology, modern methods of processing microrganisms have given rise to public concern that they might generate hazards to human beings and to the environment. OBJECTIVES AND METHODS: After summarizing the most important products and fields of application, the paper sets out to detail potential adverse effects for the health of biotechnology workers; in addition, an analysis of the literature highlights the various concepts of primary and secondary prevention. RESULTS AND CONCLUSION: Along with occupational risk factors common to other working activities (i.e. the well-known physical and chemical hazards), the peculiarity of handling microrganisms and/or different biologic systems may induce infections, immunological alterations or non-infective and non-immunologic toxic reactions in the workers involved The need is emphasized for an accurate risk assessment, careful control by means of the current monitoring strategies and implementation of the confinement measures, taking into account the criteria set by Italian legislation for occupational biological risk. Lastly, attention is focussed on examinations for the medical surveillance of workers at risk.

Adult↗

[Biological limits of exposure: evolution of interpretative and methodologic criteria].

Biological monitoring is an extremely efficient investigation tool in evaluation of exposure to exogenous substances, in both occupational and environmental settings. However, although biological tests have been widely acclaimed as the ideal approach to or as a completion of environmental measurements, they have had difficulty in becoming firmly established due to a number of limitations of various nature. Besides the numerous uncertainties in the set-up phase, which depend on the choice of indicators or criteria for their use, difficulties are still incurred in making a univocal interpretation of the results. These difficulties are due to the limited pharmaco-kinetic information available on the various substances and to the wide variability in individual biological response. The possibility of extrapolating Biological Exposure Limits (BELs) from the corresponding TLV-TWA, by means of calculations based on the experimental regressions observed between internal and external dose indices, has up to now been considered a dubious operation from a formal point of view and merely indicative for practical purposes. This paper examines the possibility of establishing BELs that are fixed taking account of the influence of the various biological variables, thus permitting a more correct, objective and generalised use of biological indicators in current practice. From the regression function and relative tolerance limits, intended as a range of values within which regression values can be expected to be found with a probability that can be fixed a priori, it is possible to calculate 3 BEL values for each environmental TLV-TWA concentration. The question of which of these different values should be selected as a BEL for practical purposes must be solved on the basis of a series of observations related to the type of investigation being performed and the context in which the results are to be used. It should be emphasized that each BEL value has its own particular sensitivity and specificity, i.e., the possibility of correctly classifying the exposure conditions in relation to the environmental values. If sensitivity and specificity values are known, it is possible to calculate the predictive value of the biological measurements compared to the environmental measurements; if numerical data on these parameters are available, account can be taken of the variability of the results in a rigourously scientific manner.(ABSTRACT TRUNCATED AT 400 WORDS)

Air Pollutants, Occupational↗

[Biological monitoring of occupational exposure to airborne pollutants].

Biological monitoring of inert substances requires knowledge of the mechanisms regulating respiratory absorption. The authors examine the influence of parameters such as work load, exposure duration and biotransformation on the respiratory absorption of inert airborne pollutants in the workplace. Attention is also given to the possibility of using biological thresholds or Biological Equivalent Limits (BELs).

Air Pollutants, Occupational↗

[Personal diffusive samplers: evaluation of the optimal sampling time].

A simple programme in basic language is formulated, which can be used with a personal computer, to evaluate the minimum and maximum sampling time of personal passive samplers at given concentrations of solvents. It is possible to evaluate also the sampler's response time to the peak concentration of the solvent and, once an arbitrary sampling time has been chosen, it is possible to know the concentration range to get exact determinations.

Air Pollutants↗

[HPLC determination of low concentrations of benzene].

A laboratory study, using generated atmosphere containing 0.14/23.3 mg/m3 of Benzene, was conducted to adapt an existing industrial hygiene monitoring method for measuring low concentrations of Benzene. This method was developed to determine concentrations of Benzene in the ambient air and around refinery/petrochemical plant. The air sample is collected on a diffusive personal sampler (Zambelli-TK 200) and analyzed by desorption with a mixture of methylene chloride and ethyl acetate followed by quantification using HPLC-Fluorescence detector. The method used did not detect aliphatic or alicyclic hydrocarbons. The HPLC-Fluorescence method is compared with a gas chromatographic method that uses capillary column and flame ionization detection after a collection of air sample on a Carbotrap 100 tube and following thermal desorption.

Air Pollutants↗

[Relationship of environmental levels, respiratory absorption and urinary concentrations of various solvents: effects of work load].

The physical demand in the workplaces can be different depending on each specific job. This involves that workers exposed to the same environmental level of an airborne can absorb different amounts of it depending on their pulmonary ventilation. Starting from the relationship between the uptake (U) and the urinary concentration (Cu) of 6 solvents (Acetone, Styrene, Xylenes, Toluene, Methylchloroform, Tetrachloroethylene) and from the equation expressing their lung uptake the expected values of a biological index after a given time of exposure can be derived. Such values are a function not only of the environmental levels of exposure (CI) but also of the pulmonary ventilation (V) (V--dependent solvents) and of the retention index (R) (V--R--dependent solvents).

Air Pollutants, Occupational↗

[Proposal of the biological monitoring of inhalation anesthetics].

The long-term occupational exposure to inhalation anaesthetics might represent a health hazard; mainly it may have an adverse effect on the reproductive outcome. Nitrous oxide is the anaesthetic employed in the largest amount during general anaesthesia and it can be used as an indicator of occupational exposure to all the components the mixture; but if the pattern of dispersion of them (when leaking into the operating theater) are not the same, two indicators should be used: N2O (gas) + another component the mixture (vapour). Our results concern practically 5 points: --Analysis of N2O by means of a diffusive personal sampler (comparison with a conventional sampling method) --Analysis of N2O in urine collected after 4 hours of exposure during routine anaesthetic work (headspace method) --Comparison of environmental and biological data concerning N2O --Comparison of environmental and biological data concerning a component of the anaesthetic mixture, forane --Proposal of biological exposure indices for nitrous oxide and forane. A close relationship between air and urine was found in 363 subjects occupationally exposed to N2O and 45 subjects exposed to forane (r: 0.95 and 0.90 respectively). On the basis of such a relationship the biological exposure index for N2O corresponding to an ambient concentration of 100 ppm (European limit) turned out to be 55 micrograms/L; the ones for forane corresponding to ambient concentrations of 2 or 10 ppm are respectively 3.4 or 14.5 micrograms/L (urinary concentrations in samples collected after 4 hours of exposure).

Anesthetics↗

Urinary elimination of p-dichlorobenzene (p-DCB) and weighted exposure concentration.

The aim of the present work is to determine p-DCB concentration in the urine of exposed workers and to verify a possible correlation with the environmental exposure. The authors studied four subjects exposed to different p-DCB environmental concentrations during a working week. The measurement of the substances was performed by means of a Hewlett-Packard 5880 A gas-chromatograph supplied with a Hewlett-Packard 5970 A Mass Selective Detector. The analysis was performed by a head space method (after determining the urine/air partition coefficient (lambda) by the multiple phase equilibration method). The lambda value (urine/air) of p-DCB is 10.8. The Authors found a significant relationship between the difference of p-DCB urinary concentration at the beginning and end of a daily work delta Cu (microgram/l) and the p-DCB environmental concentration C-I (mg/m3) (r = 0.64) (P less than 0.01); delta Cu = 0,48C-I + 15.61. We found that with an environmental exposure of 44.7 mg/m3 median value (geometrical deviation 1.15) there is an increase of p-DCB concentration in the urine of workers during the working week. For a daily environmental exposure of 450 mg/m3 (ACGIH TLV, 1984), we think that it is possible to propose a Biological Exposure Index (B.E.I.) of 250 micrograms/l as difference between beginning and end of a daily work.

Air Pollutants, Occupational↗

[Evaluation of oxygen consumption and other cardiorespiratory parameters measured during the execution of 3 types of muscular exercises used in respiratory kinesitherapy].

Oxygen consumption (VO2) and other cardiorespiratory parameters (pulmonary ventilation, tidal volume, respiratory rate, alveolar ventilation, heart rate) have been measured in 10 healthy subjects (20-40 years old) while performing 3 respiratory exercise (abdominal muscles reinforcement, scapulo-humeral articulation movements and chest expansion). The performance of the abdominal muscles reinforcement exercises requires the highest oxygen consumption. The 3 exercises decrease the "Dead space/Tidal volume" ratio and increase the alveolar ventilation.

Adult↗