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Biomedical subjects

M Isashiki

Publications and source records attributed to M Isashiki.

5 recordsLinked to original sources
PubMed1989

Pigmentary retinal degeneration in patients with HTLV-I-associated myelopathy.

Ophthalmological evaluations were made of the records of a series of 38 patients with HTLV-I-associated myelopathy, a chronic progressive myelopathy caused by human T-lymphotropic virus type I (HTLV-I). Four patients with no contributory family history showed pigmentary degenerative changes of the retina and choroid. Two of the patients (73-year-old woman, 68-year-old woman) had a progressive visual loss and night blindness with morphologic and functional features of diffuse pigmentary retinal degeneration. The other two patients (59-year-old man, 72-year-old man) complained of recently developed visual loss with sectorial or regional retinochoroidal atrophy. These elderly patients claimed that they had been healthy until a few years before presentation, not only visually but also neurologically. It was concluded, together with an epidemiologic consideration, that the coexistence of pigmentary retinal degeneration and HTLV-I-associated myelopathy is not simply chance but indicates a close association between the two conditions. It is proposed that HTLV-I infection might be a primary causative factor of degenerative changes of the retina and choroid, although the pathogenesis remains to be defined.

Aged↗
PubMed1986

Recovery of differential light sensitivity following surgery for rhegmatogenous retinal detachment.

Sixteen patients with phakic, nontraumatic rhegmatogenous retinal detachment were used in a prospective study on the change of the visual field following surgical treatment of the disease. The differential light threshold was measured across the visual field before and after surgery up to 1 year by means of the Octopus automated static perimeter. The visual sensitivity recovered prominently in the initial one to two months, followed by a slight improvement for up to a year. The final prognosis of visual sensitivity was correlated with the duration of detachment, but not with its extent or height. The recovery in the peripheral visual field was less remarkable, with residual slight defect. There was more improvement in visual sensitivity at the fovea than in visual acuity.

Adult↗
PubMed1986

Acute posterior multifocal placoid pigment epitheliopathy associated with diffuse retinal vasculitis and late haemorrhagic macular detachment.

A 20-year-old healthy man suffered rapid loss of bilateral central vision with placoid lesions at the level of the retinal pigment epithelium and choriocapillaris scattered in the posterior pole of the fundus. In addition, acute vasculitis of the retinal veins was remarkable and widespread throughout the posterior pole and midperiphery. These inflammatory signs subsided in several weeks and were succeeded by recovery of the normal visual acuity with residual pigment derangements in the deep retina. Sixteen months after the onset of the disease choroidal neovascular membranes developed in the macular region of the left eye, followed by haemorrhagic macular detachment and marked visual loss. Significant increases in the serum cold agglutinin titre occurred as isolated laboratory findings concurrently with the acute stage of the disease and the late macular complication, though no clinical or other laboratory sign suggested viral infection.

Adult↗
PubMed1986

Multiple evanescent white dot syndrome.

Two Japanese young adults had an acute unilateral visual loss with no preceding general illness. Ophthalmoscopic examination revealed multiple, small discrete yellow-white lesions which appeared to be located at the level of the retinal pigment epithelium in the posterior fundus. There was also fine granularity of the fovea, and the optic disc margin was blurred. Fluorescein angiography demonstrated early hyperfluorescence of the lesions consisting of a cluster of punctate hyperfluorescent areas and late staining of the retinal pigment epithelium. These lesions regressed in a few weeks with return of the visual function to the normal level. The clinical picture of these cases is differentiated from acute inflammatory diseases primarily involving the retinal pigment epithelium and photoreceptors, and conforms to the multiple evanescent white dot syndrome that has recently been found in residents of the midwest region of the United States of America.

Adolescent↗