[Structure-based drug design].
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Drug Design↗
Biomedical subjects
M Isiguro
Publications and source records attributed to M Isiguro.
C26 sterol in a human urine.
A new C26 sterol, 22-trans-27-norcholesta-5,22-dien-3 beta-ol, was found in the urine of a 6-year-old girl, with a clinical diagnosis of congenital adrenal hyperplasia of the salt losing type, accompanied by symptoms of mixed sex anatomy and skin pigmentation. The structure of the sterol was determined by comparison with the synthetic compound. The sterol was also detected in ther serum. This appears to be the first case in which a C26 sterol has occurred in mammalia.
Adrenocortical Hyperfunction↗