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Biomedical subjects

M Issa

Publications and source records attributed to M Issa.

30 records · Page 2Linked to original sources
PubMed1976

Multiple congenital defects associated with trisomy for long arm of No. 4.

The clinical and cytogenetic findings of a male infant with multiple congenital anomalies and trisomy for the distal third of the long arm of No. 4 are described. The abnormal chromosome was inherited from the mother who had a balanced translocation, t(4;9)(q31;q34). Trisomy for the long arm of No. 4 has previously been described in only 3 patients.

Abnormalities, Multiple↗
PubMedDate not supplied

Kinetic disposition, systemic bioavailability, tissue levels and acetylation of some sulphonamides in goats.

Sulphamethoxazole, sulphadimethyloxazole and sulphadimethoxine were once administered in goats via oral and i.v. route (100 mg/kg b.wt.) for determination of plasma and urine concentrations of the unchanged sulphonamides and their acetylated derivatives, kinetic behavior, systemic bioavailability, tissue levels and acetylation. The highest plasma concentrations of sulphamethoxazole, sulphadimethyloxazole and sulphadimethoxine were reached after 0.64, 1.31 and 0.46 hr following oral administration, with an absorption half-life of 0.84, 1.31 and 0.38 hr and an elimination half-life of 3.51, 5.01 and 5.55 hr, respectively. Following a single i.v. injection, the kinetic disposition of sulphamethoxazole and sulphadimethoxine followed a one-compartmental model with an elimination half-life of 1.48 and 1.76 hr and a total body clearance-time curve of sulphadimethyloxazole, after a single i.v. injection, could be described by a two-compartmental open model with an elimination half-life of 3.27 hr, a volume of distribution of 248.07 ml/kg and a total body clearance of 0.82 ml/kg/min. The systemic bioavailability was 19.95, 11.37 and 23.27% after oral administration of sulphamethoxazole, sulphadimethyloxazole and sulphadimethoxine, respectively. The percentages of serum protein binding of sulphamethoxazole, sulphadimethyloxazole and sulphadimethoxine were determined in most of the body tissues, collected 4 hr after i.v. injection. The highest concentration was found in kidney and liver. On the other hand, sulphamethoxazole, sulphadimethyloxazole and sulphadimethoxine were N4-acetylated in the body tissues to a higher extent than that in plasma. Acetylation was highest in rumen and skeletal muscle.

Acetylation↗
PubMedDate not supplied

Comparative studies on the effect of continuous intravenous infusion of some sulphonamides on blood and urine glucose levels in buffaloes.

Three groups of five clinically healthy buffaloes each were injected intravenously with sulphadiazine, sulphadimidine and sulphamerazine in a dose of 100 mg/kg b. wt. (as a singly initial dose of 40 mg/kg b. wt. an subsequently the plasma level kept constant by a continuous intravenous infusion of a maintenance dose of 20 mg/kg per hour over a period of 3 hours). It was found that, 1) sulphadiazine, sulphadimidine and sulphamerazine increase the plasma glucose levels at 1, 2, 2.5 and 3.5 hours from the start of i.v. infusion. 2) The glucose concentration in urine increased in the buffaloes infused i.v. with sulphadiazine. 3) The glucose level in urine of buffaloes infused i.v. with sulphadimidine and sulphamerazine was slightly increased. 4) The concentrations of sulphadiazine, sulphadimidine and sulphamerazine in plasma reached its highest level, 2.5, 2 and 2.5 hours during the i.v. infusion, respectively, then declined rapidly. 5) The concentrations of sulphadiazine, sulphadimidine and sulphamerazine in urine reached their highest concentrations 3.5 hours after i.v. infusion.

Animals↗
PubMedDate not supplied

[Treatment of an inguinal hernia by the midline preperitoneal approach using a dacron patch].

The authors report a series of 128 inguinal hernias operated by a mid line extra peritoneal incision with using Dacron Tulle material, and with a 3 years minimal follow up. The spetical risk in this series is about 0.78 percent. Not any prothesis had be removed. Relapse level was about 3.9 percent at 3 years. More of them, occur during the first year at our experience starting period. We can improve this number into less than 1 percent with experimented surgeons. The mid line way in the case of multirelapsing hernias allows an easier cleaving of the subparietal spaces, and putting in place prothesis largely over-stepping weakness zone.

Adult↗
PubMedDate not supplied

[Enteroid cyst of the spleen: a new entity? Apropos of 2 cases].

The authors describe two cases of non parasitic cyst of the spleen of "enteroid" origin on histological examination. No similar cases have yet seen described in the medical literature that we consulted. The histology of these two cases is quite unusual in that cysts are multilocular and mucoid with a cylindrical mucus secreting epithelium similar to cystic tumours of the ovary. The outcome of the first case remains favorable four years after surgery. As in the case of mucoid or enteroid cyst of the ovary, a disembryological origin seems the most likely explanation of these cyst of the spleen.

Aged↗
PubMedDate not supplied

[The surgical treatment of patients with bladder cancer in middle and old age].

Bladder tumors morphological and treatment efficacy data obtained on 246 relevant patients over 60 years of age support the benefit of surgery in combined treatment of bladder cancer in elderly patients in spite of difficulties caused by concomitant diseases and defective adaptation. High-grade poorly differentiated cancer of the bladder causing more frequent recurrences and metastases occur in patients over 60 two times less often than in younger patients. Transurethral electroresection of the bladder with removal of the tumor followed by intravesical immunoprophylaxis of the recurrences is thought a radical treatment for elderly patients with bladder cancer stage T1 and T2. At stage T3 cystectomy is preferable. Positioning of the ureters into the straight ileocecal angle provides the best results in urine derivation after cystectomy. Transurethral electroresection is optimal in the treatment of elderly patients with bladder cancer stage T1-T2 and prostatic adenoma. Indications to transurethral adenomectomy in the presence of bladder cancer must be maximally extended as adenomatous nodes provoke infravesical obstruction and speed up the recurrence of bladder cancer.

Aged↗