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M Itano

Publications and source records attributed to M Itano.

34 records · Page 2Linked to original sources
PubMed1985

Coulometric titration of sweat collected with the Webster Collection System.

Presented here are chloride results obtained by direct titration of undiluted sweat collected with the Webster Sweat Collection System. Six hundred and thirty-two sweat chloride results were reported on 604 patients. Thirty-six of thirty-nine sweat chloride results of 60 mM or greater were from patients with cystic fibrosis. Three results (61, 63 and 64 mM) were from a 12-year-old female who had one episode of rectal prolapse but after one year does not have clinical evidence of cystic fibrosis. There was one patient with a cystic fibrosis variant with intermediate range sweat chloride. All others in the intermediate range (40-59 mM) did not have cystic fibrosis. One patient with a sweat chloride reported of less than 40 mM was subsequently found to have cystic fibrosis at another institution.

Chlorides↗
PubMed1983

A new rapid slide agglutination test for amniotic fluid phosphatidylglycerol: laboratory and clinical correlation.

A new rapid slide agglutination test (Amniostat-FLM/AFLM) for amniotic fluid phosphatidylglycerol has been developed. One hundred ninety-three samples of amniotic fluid were tested for lecithin/sphingomyelin (L/S) ratio and phosphatidylglycerol by thin-layer chromatography and fluorescence polarization and compared with the AFLM. All four tests agreed in 123/193 cases. Phosphatidylglycerol and AFLM were concordant in 176/193 cases. From these samples, data were available on 105 neonates, of whom 74 were delivered within 72 hours of amniocentesis. All positive AFLM tests were associated with absence of hyaline membrane disease, of 22 negative tests, eight babies had hyaline membrane disease. Thus, preliminarily, it appears that this is a useful, rapid test for assessing fetal lung maturity, which like other tests is reliable when indicating maturity but has a high incidence of falsely immature results.

Agglutination Tests↗
PubMed1983

CAP blood gas survey--1981 and 1982.

The results of the 1982 CAP Blood Gas Survey, in which fluorocarbon-based emulsion specimens were used, are compared to the 1981 results, in which aqueous specimens were used. Interinstrument differences exist with all three analytes, pH PCO2, and PO2. There was little difference in interlaboratory precision of pH and PCO2 determinations in the two surveys. The coefficients of variation for PO2 determination were lower in 1982 than in 1981. This is attributed to the oxygen buffering capacity of fluorocarbon. Without a reference method for measuring blood pH, PCO2, and PO2, precision and interinstrument differences can be measured, but accuracy cannot.

Blood Gas Analysis↗
PubMed1980

CAP blood gas survey--first year's experience.

There were over 500 participants in the first year of the Survey. Ninety per cent identified themselves as clinical chemistry/pathology laboratories. Of the three analytes, pH was determined with the best interlaboratory precision and PO2 the lowest. Evaluation of accuracy was not possible because of the lack of an acceptable reference method. Interinstrument differences could be demonstrated by using all-methods results as a point of reference. Differences were more related to each individual instrument than to manufacturer. Because the survey specimens were buffered aqueous solutions that do not have all the characteristics of blood, results should be interpreted with caution. Some of the results, especially but not exclusively PO2, are artifacts of the survey material rather than a reflection of the state of the art of pH and blood gas analysis.

Blood Gas Analysis↗
PubMed1978

CAP Comprehensive Chemistry. Serum iron survey.

Approximately 1,600 participants replied to a special questionnaire about the serum iron determination used in their laboratories. The categories covered were (1) sample preparation, (2) system, (3) detection method, (4) reducing reagent, and (5) standards. Those using AutoAnalyzer methods uniformly had the highest reported values. The lowest values were reported by those using methods without protein removal. Whether this is a positive bias by the AutoAnalyzer group or a negative bias by methods without protein removal, or both, cannot be determined by this study. Hydroxylamine users reported lower results than others. No difference between the three commonly used chromogenic reagents, bathophenanthrolene sulfonate, tripyridyl-triazine, and ferrozine, could be demonstrated. Protein-based standards should be used when a method is found to be affected by protein. How to determine the assay value is an important problem yet to be solved.

Autoanalysis↗
PubMed1977

A technique for the repair of a single or common ventricle.

A new extensive operative technique with several points of important surgical significance was applied to six patients with a single or common ventricle in whom the types of anomalies consisted of common ventricle, Van Praagh's type C, in one instance and single ventricle, Van Praagh's type A and B, in five instances. The important points of this technique are an atrial approach designed to avoid damage to the ventricular function; reconstruction of the ventricular septum using a pouch graft with specially tailored, substitute Dacron vessels; adequate positioning of the prosthetic septum, resulting from use of a pouch graft; special consideration given to suturing at the site of attachment of the interatrial and interventricular septum to lessen damage to the conduction system, and double valve replacement. The adequacy of such extensive surgical repairs cannot be judged accurately until more patients are operated upon.

Child↗
PubMed1976

The detection of CPK1 (BB) in serum. A summary of sixteen cases.

CPK1 (BB) was detected in the sera of 16 patients during an 18-month period. Eight of 16 had undergone cardiopulmonary resuscitation for cardiac arrest or ventricular fibrillation. Four of these eight had clinical or EEG evidence of cerebral damage. The brain is the most probable source for CPK1 in these eight cases. Two others had proven brain damage, one a massive cerebral infarct and one a traumatic cerebral hematoma requiring craniotomy. One patient had membranous enterocolitis, suggesting an intestinal source for CPK1. The source for the CPK1 in the other five cases was much less obvious, but was probably the brain.

Brain Damage, Chronic↗
PubMed1975

A new approach to total repair of transposition of the great vessels: a technique for atrial autotransplantation.

We have devised a new operative procedure called atrial autotransplantation for transposition of the great vessels and applied it in 7 cases. Results were satisfactory except for one death. The bais of this technique was the experiment, using 70 dogs, in which the relationship of separation of the atrial wall and atrial septum to the development of arrhythmia was studied. It was found that reservation of the upper one sixth of the right atrial wall and the upper one third of the left atrial wall developed almost no significant arrhythmia with slow rate. By this concept and method, the left and right atria are almost completely separated, and a complete intraventricular and intra-atrial repair is made in a satisfactory operative field. Since there is no surgical intervention in the ventricular wall, postoperative cardiac function can be satisfactorily maintained. With this procedure intr-atrial conversion was performed in four cases and intraventricular conversion in three cases-the former for type I of uncomplicated transposition and type III of combined pulmonary stenosis, with or without VSD, and the latter for type II of combined large VSD. Only one patient with intraventricular conversion died of low cardiac output syndrome, probably due to incomplete relief of combined pulmonary stenosis.

Animals↗
PubMedDate not supplied

Epstein-Barr virus-associated lymphoproliferative disorder after unrelated bone marrow transplantation in a young child with Wiskott-Aldrich syndrome.

We report a case of a 16-month-old Wiskott-Aldrich syndrome (WAS) patient with a WASP gene mutation who received human leukocyte antigen (HLA)-matched, unrelated allogeneic bone marrow transplantation (BMT) followed by an Epstein-Barr virus-associated lymphoproliferative disorder (EB-LPD), diagnosed by clinical findings, polymerase chain reaction detection of the EB virus genome, and spontaneous lymphocyte proliferation of donor cell origin. EB-LPD is one of frequent lethal complications in HLA-mismatched or unrelated BMT in this syndrome. Adoptive immunotherapy with donor leukocyte transfusion, including appropriate numbers of CD3-positive T cells, was effective for the EB-LPD, achieving almost complete recovery 1 year later without any findings of graft-versus-host disease.

Bone Marrow Transplantation↗