PubMed Health⌕ Search

Biomedical subjects

M Itoi

Publications and source records attributed to M Itoi.

At least 73 records · Page 4Linked to original sources
PubMed1979

Contrast (modulation) sensitivity functions measured in patients with high refractive error with emphasis on aphakia: I. Theoretical considerations.

Recently, alterations in contrast (modulation) sensitivity functions of patients with high refractive errors have been noted. For example, this seems to be a common finding in aphakia. In some measure the observed alterations are due to the effect of the corrective lens and the optics of the eyes. These optical effects (in addition to blur) must be factored out in order to determine whether residual effects on the visual system remain. The argument is applicable to photographs of sine wave fringes as well as devices designed to produce interference patterns directly on the retina. A simple means for largely correcting these lens effects is discussed.

Aphakia↗
PubMed1975

Teratogenicities of ophthalmic drugs. I. Antiviral ophthalmic drugs.

Nonradioactive idoxuridine (IDU,5-iodo-2'-deoxyuridine), while not teratogenic to rats, does produce fetal maliformations in rabbits when administered topically to the eye in doses similar to those used clinically, 0.1% four times a day for 12 days. These maliformations include exophthalmos and clubbing of the forelegs. By contrast, trifluorothymidine (F3TdR), another highly effective antiherpetic agent currently under investigation but not available for general use, was found not to be teratogenic to rabbits, even when given in concentrations tenfold greater than the doses used to produce idoxuridine teratogenicity.

Administration, Topical↗
PubMed1975

Teratogenicities of ophthalmic drugs. II. Teratogenicities and tissue accumulation of thimerosal.

Under the conditions of this study, systemically or topically applied thimerosal was found to have no teratogenic effect even when given in concentrations approaching the 50% lethal dose of these compounds. A comparison of topical and subcutaneous administration of thimerosal to rabbits shows that a substantial concentration of mercury was present in blood and tissues of the treated animals and their offspring. Thimerosal was found to cross the blood-brain and placenta barriers.

Administration, Topical↗
PubMed1975

Experimental BUdR congenital cataracts.

Bilateral cataracts were produced in all 64 newborn rats from five pregnant rats treated on the sixteenth day of gestation with an intraperitoneal injection of bromodeoxyuridine (BUdR).

Abnormalities, Drug-Induced↗